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Cellular and Molecular Atlas of Peripheral Blood Mononuclear Cells from a Pregnant Woman After Recovery from COVID-19
《Maternal-Fetal Medicine》2023年第2期88-96,共9页Lili Du Yingyu Liang Xiaoyi Wang Lijun Huang Xingfei Pan Jingsi Chen Dunjin Chen 
National Key R&D Program of China(no.2022YFC2704501,2022YFC2704503 and 2022YFC2704505);National Natural Science Foundation of China(no.81830045 and 82071652);Sino-German Center for Research Promotion’s Rapid Response Funding Call for Bilateral Collaborative Proposals Between China and Germany in COVID-19 Related Research(grant/award no.C-0032);General Program of Guangdong Province Natural Science Foundation(no.2021A1515011039 and 2020A1515010273)。
Objective:This study aimed to investigate the immune response of a pregnant woman who recovered from the coronavirus disease 2019(COVID_(R)S)by using single-cell transcriptomic profiling of peripheral blood mononuclea...
关键词：TRANSCRIPTOME Single-cell analysis PREGNANCY Peripheral blood mononuclear cells RECOVERY COVID-19 
Single-cell transcriptomes reveal molecular specializations of neuronal cell types in the developing cerebellum被引量：2
《Journal of Molecular Cell Biology》2019年第8期636-648,共13页Jian Peng Ai-li Sheng Qi Xiao Libing Shen Xiang-Chun Ju Min Zhang Si-Ting He Chao Wu Zhen-Ge Luo 
This study was partially supported by grants from the National Natural Science Foundation of China (31490591,31330032,and 61327902);the National Key R&D Program of China (2017YFA 0700500);the Frontier Key Project of the Chinese Academy of Sciences (QYZDJ-SSW-SMCO25);Shanghai Municipal Science and Technology Major Project (2018SHZDZX05).
The cerebellum is critical for controlling motor and non-motor functions via cerebellar circuit that is composed of defined cell types, which approximately account for more than half of neurons in mammalsThe molecular...
关键词：SINGLE-CELL TRANSCRIPTOMES MOLECULAR specializations NEURONAL cell 
Computational Strategies and Algorithms for Inferring Cellular Composition of Spatial Transcriptomics Data
《Genomics, Proteomics & Bioinformatics》2024年第3期1-9,共9页Xiuying Liu Xianwen Ren 
supported by Changping Laboratory,China.Thank Xiangxing Jin for helping prepare the illustrations in this work.
Spatial transcriptomics technology has been an essential and powerful method for delineating tissue architecture at the molecular level.However,due to the limitations of the current spatial techniques,the cellular inf...
关键词：Spatial transcriptomics Single-cell sequencing Cellular composition Spot deconvolution Cell type decomposition 
A Supersmall Single-Cell Nanosensor for Intracellular K^(+) Detection被引量：1
《CCS Chemistry》2021年第9期2359-2367,共9页Xiao-Mei Shi Yi-Fan Ruan Hai-Yan Wang Wei-Wei Zhao Jing-Juan Xu Hong-Yuan Chen 
supported by the National Natural Sci-ence Foundation of China(grant nos.21327902,21675080,and 21974059);the Natural Science Founda-tion of Jiangsu Province(grant no.BK20170073);the Excellent Research Program of Nanjing University(no.ZYJH004).
Intracellular potassium ions(K^(+))play pivotal roles in many physiological processes.Several K^(+)sensors have been developed for probing cellular K^(+)fluctuations.Nevertheless,the existing solutions are incompatibl...
关键词：single-cell analysis potassium ions NANOSENSOR TRANSMEMBRANE G-quadruplex DNA 
Human obstructive(postvasectomy)and nonobstructive azoospermia-Insights from scRNA-Seq and transcriptome analysis被引量：2
《Genes & Diseases》2022年第3期766-776,共11页Shitao Chen Geng An Hanshu Wang Xiaolong Wu Ping Ping Longfei Hu Yunmei Chen Jue Fan C.Yan Cheng Fei Sun 
This work was supported by the National Key R&D Program of China(No.2018YFC1003500 to F.S.);the National Natural Science Foundation of China(No.81671510 to F.S.);the Scie nee and Tech no logy Program of Guangdo ng Province(No.2019A1515011439 to G.A.).
A substantial number of male infertility is caused by azoospermia.However,the underlying etiology and the molecular basis remain largely unknown.Through single-cell(sc)RNA sequencing,we had analyzed testis biopsy samp...
关键词：Androgen signaling Retinoic acid Sertoli cell-only syndrome SINGLE-CELL SPERMATOGENESIS 
Whole-exome sequencing and microRNA profiling reveal PI3K/AKT pathway＇s involvement in juvenile myelomonocytic leukemia
《Frontiers of Electrical and Electronic Engineering in China》2018年第1期85-97,共13页Saad M Khan Jason E Denney Michael X Wang Dong Xu 
Background： Clinical studies and genetic analyses have revealed that juvenile myelomonocytic leukemia （JMML） is caused by somatic and/or germline mutations of genes involved in the RAS/MAPK signalling pathway. Give...
关键词：SINGLE-CELL RNA-SEQ differential expression 
Advances in the Application of Single-Cell Transcriptomics in Plant Systems and Synthetic Biology
《BioDesign Research》2024年第1期51-67,共17页Md Torikul Islam Yang Liu Md Mahmudul Hassan Paul E.Abraham Jean Merlet Alice Townsend Daniel Jacobson C.Robin Buell Gerald A.Tuskan Xiaohan Yang 
supported by the Center for Bioenergy Innovation(CBI),which is a U.S.Department of Energy(DOE)Bioenergy Research Center supported by the Office of Biological and Environmental Research in the DOE Office of Science,and the DOE Genomic Science Program,as part of the Secure Ecosystem Engineering and Design Scientific(SEED)Focus Area.Oak Ridge National Laboratory is man-aged by UT-Battelle,LLC for the U.S.DOE under Contract Number DE-AC05-00OR22725;This material is based on work supported by the U.S.Department of Energy,Ofice of Science,Biological and Environmental Research Program under Award Number DE-SC0023338 to CRB.
Plants are complex systems hierarchically organized and composed of various cell types.To understand the molecular underpinnings of complex plant systems,single-cell RNA sequencing(scRNA-seq)has emerged as a powerful ...
关键词：application BIOLOGY systems PLANT ADVANCES SINGLE-CELL SYNTHETIC TRANSCRIPTOMICS 
Unlocking T cell exhaustion:Insights and implications for CAR-T cell therapy
《Acta Pharmaceutica Sinica B》2024年第8期3416-3431,共16页Dian Xiong Haijun Yu Zhi-Jun Sun 
supported by National Natural Science Foundation of China(Nos.82273202,82072996,82073349);National Key Research and Development Program(No.2022YFC2504200,China);Fundamental Research Funds for the Central Universities(No.2042024kf0021,China);Interdisciplinary Innovative Foundation of Wuhan University(No.XNJC202303,China).
Chimeric antigen receptor T(CAR-T)cell therapy as a form of adoptive cell therapy(ACT)has shown significant promise in cancer treatment,demonstrated by the FDA-approved CAR-T cell therapies targeting CD19 or B cell ma...
关键词：Cancer immunotherapy CAR-T therapy T cell exhaustion Tumor immune microenvironment Spatial immune contexture Single-cell technologies CAR-T engineering Combination therapy 
A Single-Cell Landscape of Human Liver Transplantation Reveals a Pathogenic Immune Niche Associated with Early Allograft Dysfunction
《Engineering》2024年第5期193-208,共16页Xin Shao Zheng Wang Kai Wang Xiaoyan Lu Ping Zhang Rongfang Guo Jie Liao Penghui Yang Shusen Zheng Xiao Xu Xiaohui Fan 
supported by the National Natural Science Foundation of China(82200725);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202002);the Fundamental Research Funds for the Central Universities(226-2023-00114,226-2022-00226,and 226-2023-00059);the Key Program of National Natural Science Foundation of China(81930016);the Key Research and Development Program of China(2021YFA1100500);the Major Research Plan of the National Natural Science Foundation of China(92159202);the Ningbo Top Medical and Health Research Program(2022030309).
Liver transplantation(LT)is the standard therapy for individuals afflicted with end-stage liver disease.Despite notable advancements in LT technology,the incidence of early allograft dysfunction(EAD)remains a critical...
关键词：Human liver transplantation Early allograft dysfunction Pathogenic immune niche Single-cell analysis Cell-cell communication 
高活性小鼠大脑单细胞制备及流式细胞分选
《中国细胞生物学学报》2024年第2期268-273,共6页吴佳瑜 邱琳 
小鼠脑组织内含有各种神经细胞,而大脑组织却十分脆弱。如何解离小鼠大脑组织并成功进行流式细胞分选以获得高活性、高纯度的细胞样本,对后续研究大脑相关疾病的发病机制具有重要意义。该文从样本前处理到流式细胞分选全流程作了详细的...
关键词：大脑 单细胞 制备 高活性 流式分选 
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