supported by Guangxi Medical and Health Appropriate Technology Development and Promotion Application Project(S2022022).
Background:Transmembrane emp24 trafficking protein 3(TMED3)is associated with the development of several tumors;however,whether TMED3 regulates the progression of prostate cancer remains unclear.Materials and Methods:...
This work was supported by National Key R&D Program of China(No.2018YFA0901700);National Natural Science Foundation of China(No.32271526).
This research identified four amino acid residues(Leu174,Asn297,Tyr301,and Gln291)that contribute to sub-strate recognition by the high-affinity glucose transporter Xltr1p from Trichoderma reesei.Potential hotspots af...
BACKGROUND Recent advancements in biliary tract cancer(BTC)treatment have expanded beyond surgery to include adjuvant therapy,yet the prognosis remains poor.Identifying prognostic biomarkers could enhance the assessme...
Gastrointestinal cancer(GIC)is a common and widespread form of tumor,with colonoscopy and upper gastrointestinal endoscopy available to detect relevant precancerous polyps and lesions.However,many patients are already...
Bladder cancer is a urological tumor with high rates of recurrence despite recent advances in novel therapies.Many proteins involved in the molecular mechanisms are currently an enigma,especially the transmembrane 9 s...
supported by the National Natural Science Foundation of China(Grant No.32271165);Shanghai Clinical Research Center of Plastic and Reconstructive Surgery supported by the Science and Technology Commission of Shanghai Municipality(Grant No.22MC1940300);the Innovative Research Team of High-level Local Universities in Shanghai(Grant No.SHSMU-ZDCX20210400);the Key Laboratory Program of the Education Commission of Shanghai Municipality(No.ZDSYS14005);China Postdoctoral Science Foundation(Grant No.2022M722127).
The discovery of G-protein coupled receptor(GPCR)accessory proteins has fundamentally redefined the pharmacological concept of GPCR signaling,demonstrating a more complex molecular basis for receptor specificity on th...
supported by The National Key Research and Development Program of China(2022YFD1200704--3);Crop Varietal Improvement and Insect Pests Control by Nuclear Radiation,Platform for Mutation Breeding by Radiation of Sichuan(2021YFYZ0011);Natural Science Foundation of Sichuan Province(2022NSFSC1635);Applied Basic Research Programs of Sichuan Provincial Science and Technology Department(2020YJ0249)。
Maize plant architecture influences planting density and,in turn,grain yield.Most of the plant architecture-related traits can be described as organ size.We describe a miniature maize mutant,Tiny plant 4(Tip4),which e...
In this editorial we comment on the article by Wei et al,published in the recent issue of the World Journal of Clinical Oncology.The authors investigated the role of Transmembrane 9 superfamily member 1(TM9SF1)protein...
the National Natural Science Foundation of China,No.82273457;the Natural Science Foundation of Guangdong Province,No.2021A1515012180,2023A1515012762 and No.2019A1515010962;Special Grant for Key Area Programs of Guangdong Department of Education,No.2021ZDZX2040;Science and Technology Special Project of Guangdong Province,No.210715216902829.
Chronic inflammation is known to increase the risk of gastrointestinal cancers(GICs),the common solid tumors worldwide.Precancerous lesions,such as chronic atrophic inflammation and ulcers,are related to inflammatory ...
supported by grants from the National Key R&D Program of China(2018YFA0507103 to X.J.,2021YFA1301500 to F.S.);the National Natural Science Foundation of China(32270139 to X.J.);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37040102 to F.S.);the National Natural Science Foundation of China(32071187 to Y.Z.);the National Key Research and Development Program(2019YFA0904101 to Y.Z.);the program for Innovative Talents and Entrepreneur in Jiangsu;the Fundamental Research Funds for the Central Universities.
Dear Editor,In the nematode Caenorhabditis elegans,the systemic RNA interference defective protein 1(SID-1)plays a crucial role in systemic RNA interference(RNAi)by facilitating the transport of exogenous double-stran...