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A systematic survey of LU domain-containing proteins reveals a novel human gene,LY6A,which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors被引量：1
《Frontiers of Medicine》2023年第3期458-475,共18页Dan Liu Chunhui Xu Yanting Liu Wen Ouyang Shaojian Lin Aining Xu Yuanliang Zhang Yinyin Xie Qiuhua Huang Weili Zhao Zhu Chen Lan Wang Saijuan Chen Jinyan Huang Zhe Bao Wu Xiaojian Sun 
supported by the National Key Research and Development Plan of China(No.2018YFA0107802 to Xiaojian Sun,Nos.2018YFA0107200 and 2018YFA0800203 to Lan Wang);the General Program of the National Natural Science Foundation of China(Nos.81470316 and 81670094 to Xiaojian Sun,No.81972339 to Zhe Bao Wu,Nos.81570122 and 81770205 to Jinyan Huang,Nos.81670122 and 81970150 to Lan Wang);the National Research Center for Translational Medicine(Shanghai)grant(No.NRCTM(SH)-2019-05 to Zhe Bao Wu);the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant(No.20152506 to Xiaojian Sun);Shanghai Collaborative Innovation Program on Regenerative Medicine and Stem Cell Research(No.2019CXJQ01 to Saijuan Chen and Xiaojian Sun);Innovative Research Team of High-level Local Universities in Shanghai(to Weili Zhao and Xiaojian Sun);the Samuel Waxman Cancer Research Foundation;the Shanghai Guangci Translational Medical Research Development Foundation.
The Ly-6 and uPAR(LU)domain-containing proteins represent a large family of cell-surface markers.In particular,mouse Ly-6A/Sca-1 is a widely used marker for various stem cells;however,its human ortholog is missing.In ...
关键词：LU domain-containing protein family novel human gene LY6A pituitary tumor biomarker nonsynonymous SNP GPI-anchored protein 
Colonic vitamin D receptor expression is inversely associated with disease activity and jumonji domain-containing 3 in active ulcerative colitis被引量：1
《World Journal of Gastroenterology》2020年第46期7352-7366,共15页Hong-Qian Wang Wen-Hui Zhang Ya-Qi Wang Xiao-Pan Geng Ming-Wei Wang Yuan-Yuan Fan Jing Guan Ji-Long Shen Xi Chen 
Supported by The Key Projects of Natural Science Research of Anhui Province in China,No.201904a07020043.
BACKGROUND The expression of jumonji domain-containing 3(Jmjd3)and trimethylated H3 lysine 27(H3K27me3)in active ulcerative colitis(UC)and the correlation between vitamin D receptor(VDR)and the Jmjd3 pathway are unkno...
关键词：Vitamin D Ulcerative colitis Disease activity Vitamin D receptor Jumonji domain-containing 3 Trimethylated H3 lysine 27 
Insulin resistance and steatosis in HBV-HCV co-infected patients: Role of PNPLA3 polymorphisms and impact on liver fibrosis progression被引量：2
《World Journal of Hepatology》2014年第9期677-684,共8页Rosa Zampino Adriana Boemio Aldo Marrone Luciano Restivo Maria Chiara Fascione Riccardo Nevola Luigi Elio Adinolfi Nicola Coppola Carmine Minichini Mario Starace Evangelista Sagnelli Grazia Cirillo Emanuele Miraglia del Giudice Maria Stanzione Emanuele Durante-Mangoni Giovanna Salzillo 
Supported by Regione Campania,Italy
AIM:To evaluate steatosis,insulin resistance(IR)and patatin-like phospholipase domain-containing 3(PNPLA3) and their relation to disease progression in hepatitis B and C viruses(HCV-HBV) coinfected patients.METHODS:Th...
关键词：STEATOSIS Insulin resistance Hepatitis B and C viruses CO-INFECTION Patatin-like PHOSPHOLIPASE domain-containing 3 Liver fibrosis 
OsABT,a Rice WD40 Domain-Containing Protein,Is Involved in Abiotic Stress Tolerance被引量：2
《Rice science》2022年第3期247-256,共10页CHEN Eryong SHEN Bo 
supported by the Major Program of the Zhejiang Province for Food Crop Breeding(Grant No.2016C02050-6);the Key Program of Hangzhou Agricultural Scientific Research(Grant No.20191203B08)。
Plant growth and crop productivity are severely affected by abiotic stress on a global scale.WD40 repeat-containing proteins play a significant role in the development and environmental adaptation of eukaryotes.In thi...
关键词：abscisic acid ARABIDOPSIS drought stress RICE salt stress WD40 domain-containing protein 
Qingchi San(青赤散)treats ulcerative colitis in mice by inhibiting the nuclear factor-kappa B signaling pathway and Nucleotide-binding oligomerization domain,leucine-rich repeat and pyrin domain-containing 3 inflammasome formation
《Journal of Traditional Chinese Medicine》2023年第1期68-77,共10页ZHOU Zhenghua JI Jianbin WANG Hongxia YAN Lin KANG Hongchang 
Supported by the National Key Research and Development Program(Grant 2018YFC1705403):Clinical Effect Evaluation of Chinese Medicine on Moderately Active Ulcerative Colitis;Natural Science Foundation of Tianjin(Grant18JCYBJC26000):Study on the Mechanism of Qingchi San Treating Ulcerative Colitis By Regulating Gut Microflora;Scientific Research Program of Tianjin Education Commission(Grant 2017KJ155):based onγδT-NLRP3 Inflammasome-Caspase Pathway;Qingchi San Regulates Gut Microflora to Treat UC。
OBJECTIVE:To investigate the efficacy of Qingchi San(青赤散,QCS),a preparation of Traditional Chinese Medicine,on ulcerative colitis(UC)in mice by inhibiting the nuclearfactor-kappa B(NF-κB)signaling pathway and nucl...
关键词：colitis ulcerative NF-kappa B disease activity index NLR family pyrin domain-containing 3 protein INFLAMMASOMES Qingchi San 
A Novel Mutation in the Pyrin Domain of the NOD-like Receptor Family Pyrin Domain Containing Protein 3 in Muckle-Wells Syndrome被引量：2
《Chinese Medical Journal》2017年第5期586-593,共8页Jian Hu Yun Zhu Jian-Zhong Zhang Rong-Guang Zhang Hou-Min Li 
This work was supported by the grant from the National Natural Science Foundation of China （No. 81201267）.
Background： Cryopyrin-associated periodic syndrome （CAPS） is a group of rare, heterogeneous autoinflammatory disease characterized by interleukin （IL）-1β-mediated systemic inflammation and clinical symptoms invo...
关键词：Muckle-Wells Syndrome Mutation NOD-like Receptor Family Pyrin Domain-containing Protein 3 Pyrin Domain 
AstragalosideⅣplays a role in reducing radiation-induced liver inflammation in mice by inhibiting thioredoxin-interacting protein/nod-like receptor protein 3 signaling pathway被引量：1
《Journal of Traditional Chinese Medicine》2023年第1期87-94,共8页DING Yanping DONG Xiaoqing MA Yifan CHEN Lili ZHOU Jie LI Xinyan SHAO Baoping 
Supported by Natural Science Foundation-Funded Project:Molecular Mechanism of the Brain AQP4 Adaptation to the Extreme Hhypoxia in the Qinghai-Tibet Plateau Animal(No.31760271)。
OBJECTIVE:To investigate the efficacy of Astragaloside IV(AS-IV)on radiation-induced liver inflammation in mice.METHODS:The mice were divided into normal group,dimethyl sulfoxide solvent group,irradiation group(IR),ir...
关键词：radiation ionizing astragalosideⅣ liver inflammation NLR family pyrin domain-containing 3 protein thioredoxin-interacting protein 
Blocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2
《Science China(Life Sciences)》2025年第1期189-203,共15页Wenjie Li Wenyi Mei Hewei Jiang Jie Wang Xiaoli Li Lina Quan Yanyan Diao Yanni Ma Sisi Fan Zhuwei Xie Mengdie Gong Huan Zhu Dewen Bi Feng Zhang Lei Ma Jian Zhang Yufeng Gao Aris Paschalidis Honghuang Lin Fangfang Liu Kangdong Liu Mingliang Ye Zhenjiang Zhao Yajun Duan Zhuo Chen Yufang Xu Weilie Xiao Shengce Tao Lili Zhu Honglin Li 
supported in part by the National Natural Science Foundation of China (81825020, 82150208, 82260682);the National Key R&D Program of China (2022YFC3400501, 2022YFC3400504);the Shanghai Science and Technology Commission Biomedical Science and Technology Support Special Project (21S11907900, 20S11901000);Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform (2022YKZY001);sponsored by the National Program for Special Supports of Eminent Professionals;National Program for Support of Top-notch Young Professionals
Targeting the PD-1/PD-L1 axis with small-molecular inhibitors is a promising approach for immunotherapy.Here,we identify a natural pentacyclic triterpenoid,Pygenic Acid A(PA),as a PD-1 signaling inhibitor.PA exerts an...
关键词：pygenic acid A programmed death-1 immunoreceptor tyrosine-based switch motif SH2 domain-containing protein-tyrosine phosphatase-2 target identification site recognition 
Structural insights of phosphorylated into the recognition FUNDC1 by LC3B in mitophagy被引量：27
《Protein & Cell》2017年第1期25-38,共14页Mengqi Lv Chongyuan Wang Fudong Li Junhui Peng Bin Wen Qingguo Gong Yunyu Shi Yajun-Tang 
This work was supported by National Natural Science Founda- tion （Grant No. 31400629）; the Strategic Priority Research Program of the Chinese Academy of Science （No. XDB08010101）; Ministry Of Science And Technology of China （No. 2016YFA0500700）; China Postdoctoral Science Foundation （No. 2015M582009 and 2016T90579） and National Natural Science Foundation （Grant No. 31330018）.
Mitophagy is an essential intracellular process that eliminates dysfunctional mitochondria and maintains cellular homeostasis. Mitophagy is regulated by the post-translational modification of mitophagy receptors. Fun1...
关键词：microtubule-associated protein light chain 3 beta （LC3B） fun14 domain-containing protein 1 （FUNDC1） PHOSPHORYLATION selective mitophagy 
Nucleotide-binding domain,leucine-rich repeat,and pyrin domaincontaining protein 3 inflammasome:From action mechanism to therapeutic target in clinical trials
《World Journal of Gastrointestinal Oncology》2025年第2期6-16,共11页Chun-Ye Zhang Shuai Liu Yu-Xiang Sui Ming Yang 
The nucleotide-binding domain,leucine-rich repeat,and pyrin domain-containing protein 3(NLRP3)inflammasome is a critical modulator in inflammatory disease.Activation and mutation of NLRP3 can cause severe inflammation...
关键词：Nucleotide-binding domain leucine-rich repeat and pyrin domain-containing protein 3 Metabolic disease INFLAMMATION Cancer IMMUNOTHERAPY Clinical trial 
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