食源性抗炎肽的制备、分离、鉴定及其抗炎机制研究进展  

Research progress in the preparation,isolation,identification and anti-inflammatory mechanism of anti-inflammatory peptides derived from food

作　　者：汪雄[1] 赵燕[2] 徐明生[1] 姚瑶[1] 张梦雅[1] 涂勇刚[1] 

机构地区：[1]江西农业大学,江西省天然产物与功能食品重点实验室,食品科学与工程学院,江西南昌330045 [2]南昌大学,生物质转化教育部工程研究中心,江西南昌330047

出　　处：《食品工业科技》2017年第15期335-341,共7页Science and Technology of Food Industry

基　　金：江西省杰出青年人才资助计划项目(20162BCB23031);江西省青年科学家培养对象计划项目(20153BCB23028);江西省自然科学基金项目(20171BAB204027)

摘　　要：生物活性肽是生命和食品科学领域的研究热点之一。其抑菌、降血压、调节免疫、抗病毒、抗炎等活性已相继被证实,其中肽的抗炎作用研究相对较为薄弱。慢性炎症严重影响人体健康,而传统治疗炎症药物均有一定副作用,食源性抗炎肽的开发应用有望为机体炎性反应提供新的抗炎策略。本文综述了食源性抗炎活性肽的制备、分离纯化、鉴定以及抗炎活性与分子作用机制的研究进展,并对其研究进行了展望,为食源性抗炎肽的进一步深入研究提供参考。Bioactive peptides are one of the hotspots in the area of life and food science.Antimicrobial activity ,antihypertensive effect, immune regulation, anti-viral and anti-inflammaroty activity of peptides have gradually been confirmed, but research on anti- inflammatory of peptides is limited. Chronic inflammation seriously affects human health, and the traditional drugs of inflammatory treatment show some side effects.The development and application of food-derived anti-inflammatory peptides is expected to provide new anti - inflammatory strategy for the body inflammatory response. Therefore, this paper reviewed the preparation, purification, identification and molecular mechanism of food-derived anti- inflammatory peptides. Directions for further study and their potential application in practice were also discussed, which provided a reference for further in-depth study of anti-inflammatory peptides derived from food.

关 键 词：食源性 抗炎肽 炎症 免疫 抗炎机制 

分 类 号：TS201.1[轻工技术与工程—食品科学]