国家自然科学基金(R2090392)

作品数：3被引量：21H指数：3
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相关期刊：《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》更多>>
相关主题：APOPTOSISBORTEZOMIBT-CELLNF-KBTRIPTOLIDE更多>>
相关领域：生物学农业科学理学医药卫生更多>>
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Matrine and CYC116 Synergistically Inhibit Growth and Induce Apoptosis in Multiple Myeloma Cells被引量：3
《Chinese Journal of Integrative Medicine》2015年第8期635-639,共5页周郁鸿 冯尽意 尤良顺 孟海涛 钱文斌 
Supported by National Natural Science Foundation of China(No.30871099);Zhejiang Provincial Natural Science Foundation of China(No.R2090392);Administration of Traditional Chinese Medicine of Zhejiang Province(No.2000C25)
Objective： To investigate whether CYC116 can potentiate matdne-dependent growth inhibition and apoptosis in multiple myeloma （MM） cells. Methods： The dose response relationship of matrine to dexamethasone-resistan...
关键词：APOPTOSIS aurora kinase CYC116 INHIBITOR MATRINE multiple myeloma 
Perifosine induces protective autophagy and upregulation of ATG5 in human chronic myelogenous leukemia cells in vitro被引量：7
《Acta Pharmacologica Sinica》2012年第4期542-550,共9页Yin TONG Yan-yan LIU Liang-shun YOU Wen-bin QIAN 
Acknowledgements This work was supported by the Zhejiang Provincial Natural Science Foundation of China （R2090392） and Science and the Technology Foundation of Zhejiang Province （2011c23089）. We are grateful to Prof Tamotsu YOSHIMORI, PhD, for providing the EGFP-LC3 plasmid and to Li WANG （Zhejiang University） for her help with TEM.
Aim： The efficacy of the Akt inhibitor perifosine against chronic myeloid leukemia （CML） cells and its mechanisms of action are unknown. In this study, the cytotoxic effects of perifosine on CML and acute myeloid l...
关键词：Akt inhibitor PERIFOSINE chronic myeloid leukemia acute myeloid leukemia AUTOPHAGY APOPTOSIS beclin 1 ATG5 
Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-κB activity and miR-16-1＊被引量：11
《Acta Pharmacologica Sinica》2011年第4期503-511,共9页Hai-tao MENG Li ZHU Wan-mao NI Liang-shun YOU Jie JIN Wen-bin QIAN 
Acknowledgements This work was supported by the National key Technology R＆D Program for the 11th Five-Year plan （No 2008BAI61B01）; Zhejiang Provincial Natural Science Foundation of China （No R2090392）.
Aim： To examine the effects of triptolide （TPL） on T-cell leukemia cells and identify their underlying mechanisms. Methods： The cytotoxicity of TPL was assessed by MTT assay. Cell apoptosis was determined using an...
关键词：TRIPTOLIDE T-cell lymphocytic leukemia NF-KB miR-16-1＊ BORTEZOMIB 
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