国家自然科学基金(81373343)

作品数：6被引量：8H指数：2
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相关机构：北京大学更多>>
相关期刊：《Journal of Chinese Pharmaceutical Sciences》《中国新药杂志》更多>>
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Construction of folate-conjugated epirubicin liposomes for enhancing the cellular uptake and the co-localization with nuclei of invasive breast cancer cells被引量：3
《Journal of Chinese Pharmaceutical Sciences》2018年第4期229-240,共12页Yingzi Bu Limin Mu Lei Liu Wanliang Lu 
The National Natural Science Foundation of China(Grant No.81373343 and 81673367)
Drug resistance of anthracycline in the invasive cancer is associated with the lowered cellular drug uptake and diminished co-localization of drug with nuclei. In the present study, we aimed to construct the folate-co...
关键词：Folate conjugated liposomes EPIRUBICIN Cellular uptake Co-localization with nuclei Invasive breast cancer 
Augmented efficacy and the mechanism of a combined use of daunorubicin with rofecoxib in treatment of triple-negative breast cancer
《Journal of Chinese Pharmaceutical Sciences》2016年第6期438-447,共10页赵曜 张婧莹 胡英杰 吴佳栓 卜英子 吕万良 
National Natural Science Foundation of China(Grant No.81373343);the Key Grant of Beijing Natural Science Foundation(Grant No.7131009)
Triple-negative breast cancer is the tumor that lacks expressions of estrogen receptor（ER）, progesterone receptor（PR） and human epidermal growth factor receptor-2（HER2）. A regular chemotherapy cannot eradicate t...
关键词：DAUNORUBICIN ROFECOXIB Triple-negative breast cancer APOPTOSIS AUTOPHAGY 
The use of a new functional glucose conjugate material, TPGS_(1000)-Glu, in treatment of brain glioma by incorporating into epirubicin liposomes被引量：2
《Journal of Chinese Pharmaceutical Sciences》2016年第4期266-274,共9页沐黎敏 吴佳栓 谢红军 刘磊 曾凡 阎妍 赵曜 胡英杰 卜英子 吕万良 
National Basic Research Program of China(973 Program,Grant No.2013CB932501);Beijing Natural Science Foundation(Grant No.7131009);National Natural Science Foundation of China(Grant No.81373343)
Most of antieancer agents can not be used for treatment of brain glioma due to the existence of the blood brain barrier （BBB）. The over-expression of glucose transporters （GLUTs） on the BBB and brain glioma cells ...
关键词：TPGS1000-Glu EPIRUBICIN Liposomes Glucose transporters Brain glioma 
Efficacy and mechanism of a compound epirubicin plus quinine injection for the treatment of drug--resistant breast cancer
《Journal of Chinese Pharmaceutical Sciences》2015年第9期563-571,共9页刘磊 居瑞军 谢红军 曾凡 张诚翔 赵炜煜 吕万良 
National Natural Science Foundation of China(Grant No.81172991 and 81373343)
A single drug chemotherapy fails to eliminate residual cancer cells due to the existence of the multidrug resistance （MDR）. In the present study, we aimed to develop a compound epirubicin plus quinine injection, to ...
关键词：Compound epirubicin plus quinine injection Blocking drug effiux Apoptosis Resistant breast cancer EFFICACY 
新型靶向性表阿霉素复方脂质体的研制及其对侵袭性乳腺癌细胞的抑制效应被引量：3
《中国新药杂志》2014年第19期2291-2297,共7页孙梦舸 石继凤 李秀英 赵曜 吕万良 
国家自然科学基金(81373343);北京市自然科学基金重点项目(7131009);教育部创新团队基金(BMU20110263)
目的:构建新型靶向性载药脂质体、并考察其对侵袭性乳腺癌细胞的抑制效应。方法:以叶酸类似物雷替曲塞为靶向分子,通过与长循环磷脂材料进行化学合成,制备针对乳腺癌叶酸受体的靶向性功能材料;并将之修饰到脂质体上,以表阿霉素为抗癌药...
关键词：雷替曲塞 靶向性表阿霉素复方脂质体 表阿霉素 姜黄素 侵袭性乳腺癌 
Development of targeted sunitinib plus vinorelbine liposomes modified with DSPE-PEG_(2000)-pemetrexed conjugate and the inhibitory effect toresistant breast cancer in vitro
《Journal of Chinese Pharmaceutical Sciences》2014年第5期287-294,共8页石继凤 居瑞军 孙梦舸 李秀英 赵曜 曾凡 吕万良 
Beijing Natural Science Foundation(Grant No.7131009);the National Basic Research Program of China(Grant No.973 program,2013CB932501);the National Natural Science Foundation of China(Grant No.81373343);the Innovation Team of Ministry of Education(Grant No.BMU20110263)
Multidrug resistance （MDR） of breast cancer is a major cause of failure in chemotherapy. In the present study, a distearoylphosphatidyl ethanolamine-polyethylene glycol-pemetrexed （DSPE-PEG2000-PMT） conjugate was ...
关键词：DSPE-PEG2000-pemetrexed SUNITINIB VINORELBINE Targeted liposomes Resistant breast cancer 
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