by research grants from the National Nature Science Foundation(NO.81000541and NO.81171201);by the National Basic Research Program(NO.2011CB510003).
Alzheimer’s disease(AD)is the most common neurodegenerative disorder affecting the elderly people.AD is characterized by progressive and gradual decline in cognitive function and memory loss.While familial early-onse...
supported by grants from the National Natural Science Foundation of China(81370470 and 81171201);National Basic Research Development Program of China 2011CB510003)
Hyposmia, identified as reduced sensitivity to odor, is a common non-motor symptom of Parkinson's disease (PD) that antedates the typical motor symptoms by several years. It occurs in -90% of early-stage cases of P...
To develop a C. elegans model of amyotrophic lateral sclerosis (ALS) and to evaluate the role of autophagy in the disease. Methods: Stable transgenic worms expressing the G93A mutant form of Cu,Zn-superoxide dismut...
Ubiquitin-proteasome system (UPS) and autophagosome-lysosome pathway (ALP) are the most important machineries respon- sible for protein degradation in Parkinson's disease (PD). The aim of this study is to inves...