国家重点基础研究发展计划(2011CB510003)

作品数：5被引量：23H指数：3
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相关期刊：《Acta Pharmacologica Sinica》《Translational Neurodegeneration》更多>>
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NADPH ameliorates MPTP-induced dopaminergic neurodegeneration through inhibiting p38MAPK activation被引量：4
《Acta Pharmacologica Sinica》2019年第2期180-191,共12页Jing-si Zhou Zhou Zhu Feng Wu Ying Zhou Rui Sheng Jun-chao Wu Zheng-hong Qin 
National Key Basic Science Research Project (973 Project,2011CB510003);the Natural Science Foundation of China (No.31300893).
Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by the selective loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). Although the pathogenic mechanism un...
关键词：NADPH PD MPTP ROS P-P38MAPK TP53 
Epigenetic modifications of chronic hypoxiamediated neurodegeneration in Alzheimer’s disease被引量：1
《Translational Neurodegeneration》2014年第1期40-45,共6页Hui Liu Weidong Le 
by research grants from the National Nature Science Foundation(NO.81000541and NO.81171201);by the National Basic Research Program(NO.2011CB510003).
Alzheimer’s disease(AD)is the most common neurodegenerative disorder affecting the elderly people.AD is characterized by progressive and gradual decline in cognitive function and memory loss.While familial early-onse...
关键词：Alzheimer’s disease Chronic hypoxia Epigenetic modification DNA methylation Histone acetylation 
Coordination of autophagy with other cellular activities被引量：6
《Acta Pharmacologica Sinica》2013年第5期585-594,共10页Yan WANG Zheng-hong QIN 
Acknowledgements This work was supported by grants from the National Natu- ral Science Foundation of China （No 81000547; 30930035）, the National Basic Research Program of China （No 2011CB510003）, and the Priority Academic Program Development of Jiangsu Higher Education Institutions （PAPD）.
The cell biological phenomenon of autophagy has attracted increasing attention in recent years, partly as a consequence of the dis- covery of key components of its cellular machinery. Autophagy plays a crucial rote in...
关键词：AUTOPHAGY APOPTOSIS UPS AGING IMMUNITY energy homeostasis cell growth 
Establishing a novel C. elegans model to investigate the role of autophagy in amyotrophic lateral sclerosis被引量：3
《Acta Pharmacologica Sinica》2013年第5期644-650,共7页Jia LI Kai-xing HUANG Wei-dong LE 
To develop a C. elegans model of amyotrophic lateral sclerosis （ALS） and to evaluate the role of autophagy in the disease. Methods： Stable transgenic worms expressing the G93A mutant form of Cu,Zn-superoxide dismut...
关键词：amyotrophic lateral sclerosis C. elegans SOD1 motor defect axon guidance AUTOPHAGY daf-2（e1370） 
Adaptive changes in autophagy after UPS impairment in Parkinson＇s disease被引量：9
《Acta Pharmacologica Sinica》2013年第5期667-673,共7页Yu-fei SHEN Yu TANG Xiao-jie ZHANG Kai-xing HUANG Wei-dong LE 
Ubiquitin-proteasome system （UPS） and autophagosome-lysosome pathway （ALP） are the most important machineries respon- sible for protein degradation in Parkinson＇s disease （PD）. The aim of this study is to inves...
关键词：proteasome inhibitor LACTACYSTIN ubiquitin-proteasome system dopaminergic neuron Parkinson＇s disease autophagy-lysosomal pathway AUTOPHAGOSOME mTOR Beclin 1 
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