国家自然科学基金(21002004)

作品数：4被引量：1H指数：1
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相关作者：王萌张礼和邢磊杨振军关注更多>>
相关机构：北京大学更多>>
相关期刊：《Journal of Chinese Pharmaceutical Sciences》《Chinese Chemical Letters》更多>>
相关主题：ANTI-HIVANALOGS31P_NMRSTERIE更多>>
相关领域：理学医药卫生化学工程更多>>
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Insight into the deamination mechanism of 6-cyclopropylamino guanosine analogs for anti-HIV drug design
《Chinese Chemical Letters》2016年第12期1759-1762,共4页Xin-Meng Fan Xian-Tao Yang Yu-Jia Guo Ren-Min Wu De-Lin Pan Zhu Guan Xiao-Mei Ling Li-He Zhang Zhen-Jun Yang 
supported by National Natural Science Foundation of China (NSFC) (Nos.21172010,21002004)
Deamination is a crucial step in the transformation of 6-cyclopropylamino guanosine prodrug to its active form. A convenient method using capillary electrophoresis （CE） without sample labeling was developed to analy...
关键词：DEAMINATION 6-Cyclopropylamino guanosine Mouse liver homogenate Adenosine deaminase Anti-HIV drug design 
A novel method for the synthesis of sulfur substituted-cyclopyrophosphate of cADPR analogs
《Chinese Chemical Letters》2014年第12期1583-1585,共3页Ren-Min Wu Na Qi Yu-Wen Jia Zhu Guan Liang-Ren Zhang Li-He Zhang Zhen-Jun Yang 
scientific research funding from the National Natural Science Foundation of China(Nos.21332010,21172010, 21002004)
A facile and efficient protocol for the synthesis of sulfur substituted-cyclopyrophosphate of cIDPRE（P_S^1-cIDPRE） was developed.The key step was the cyclization process which was completed by the sulfur substituted...
关键词：cADPR cIDPRE Phosphoramidite strategy Cyclopyrophosphate 
Synthesis and the anti-HIV activity of novel dinucleotides containing L-isonucleosides
《Journal of Chinese Pharmaceutical Sciences》2013年第4期314-318,共5页王萌 邢磊 陆世芳 关注 杨振军 张礼和 
National Natural Science Foundation of China (Grant No. 20832008 and 21002004)
Three dinucleotides containing L-isonucleosides at 5＇-end were synthesized by an elegant phosphoramidite one-pot method. Their binding modes with HIV integrase were simulated and their anti-HIV activities in pseudoty...
关键词：HIV integrase DINUCLEOTIDES SYNTHESIS ANTI-HIV Binding modes 
Atropisomerism of diastereomer diribonucleoside phosphotriester被引量：1
《Chinese Chemical Letters》2013年第1期13-16,共4页Lu-Xin Na Xu-Lin Sun Meng Wang Kun-Feng Li Lei Xing Zhuo Chen Zhu Guan Zhen-Jun Yang 
financially supported by the National Natural Science Foundation of China(Nos.20832008 and 21002004)
Linear diribonucleoside phosphotriester is an important intermediate for synthesizing biologically important compounds, such as cyclic bis（3＇-5＇） diguanylic acid （c-di-GMP） and its analogues. Atropisomerism of d...
关键词：Diribonucleoside phosphotriesterAtropisomer31p NMR 
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