Aim: To investigate the anticancer property and possible mechanism of action of a novel sugar-substituted thalidomide derivative (STA-35) on HL-60 cells in vitro. Methods: TNF-α-induced NF-κB activation was dete...
National Natural Sciences Foundation of China (Grant No.30330690 and 30672525);Grant from the State Key Laboratory of Natural and Biomimetic Drugs,Peking University.
Thalidomide (α-N-phthalimido-glutarimide, TLD) is a kind of anti-angiogenic and anti-inflammatory drug, and showed effects in the treatment of several disease entities. In this study, the biological effects of a no...