Dear Editor,Significant breakthrough in science often relies on the development of original tools that can perform novel functions,thus help reveal previously unknown knowledge that is not feasible to obtain using con...
Acknowledgments We thank Drs David G Schatz, David Roth, Stephen Desiderio and Martin Gellert for providing recombination plasmids. We are grateful to our colleagues H Chen for animal husbandry and W Bian for cell sorting. This work was supported by grants from National Basic Research Program of China (2013CB835300 and 2012CB518700), National Natural Science Foundation of China (31270936 and 81261120380) and Shanghai Municipal Government (12XD 1405800).
RAG1 and RAG2 proteins are key components in V(D)J recombination. The core region of RAG1 is capable of catalyzing the recombination reaction; however, the biological function of non-core RAG1 remains largely unknow...
supported in part by an International Early Career Scientist grant from the Howard Hughes Medical Institute;the Beijing Scholar Program to Shao Feng;Other financial supports include the National Basic Research Program of China(2012CB518700),;the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB08020202);National Science Fund for Distinguished Young Scholars(31225002)to Shao Feng
Pyrin,encoded by MEFV gene,is conserved in humans and mice.Mutations in the MEFV gene are associated with the human autoinflammatory disease familial Mediterranean fever(FMF).Pyrin can interact with the inflammasome a...