国家重点基础研究发展计划(2013CB933701)

作品数：8被引量：34H指数：3
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相关作者：张江晖张幼怡更多>>
相关机构：北京大学第三医院更多>>
相关期刊：《Science Bulletin》《National Science Review》《Science China(Life Sciences)》《Science China Chemistry》更多>>
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Single-molecule imaging reveals the stoichiometry change of epidermal growth factor receptor during transactivation by β_2-adrenergic receptor被引量：1
《Science China Chemistry》2017年第10期1310-1317,共8页Mingliang Zhang Kangmin He Jimin Wu Nan Li Jinghe Yuan Wei Zhou Zi Ye Zijian Li Han Xiao Zhizhen Lv Youyi Zhang Xiaohong Fang 
supported by the National Basic Research Program of China (2013CB933701);the National Natural Science Foundation of China (81530009, 21127901, 91213305);Chinese Academy of Science
Stimulation of G protein-coupled receptors(GPCRs) can lead to the transactivation of the epidermal growth factor receptors(EGFR). The cross-communication between the two signaling pathways regulates several important ...
关键词：transactivation epidermal growth factor receptor（EGFR） β2-adrenergic receptor（β2-AR） single molecule imaging 
Single-molecule imaging and tracking of molecular dynamics in living cells被引量：2
《National Science Review》2017年第5期739-760,共22页Nan Li Rong Zhao Yahong Sun Zi Ye Kangmin He Xiaohong Fang 
supported by National Basic Research Program of China(2013CB933701);National Natural Science Foundation of China(21127901,91413119,91213305);Chinese Academy of Sciences
Unlike the ensemble-averaging measurements, the single-molecule imaging and tracking(SMIT) in living cells provides the real-time quantitative information about the locations, kinetics, dynamics and interactions of in...
关键词：single-molecule imaging single-molecule tracking live-cell imaging fluorescence microscopy quantitative analysis 
Single-molecule force spectroscopy study of the effect of cigarette carcinogens on thrombomodulin–thrombin interaction被引量：2
《Science Bulletin》2016年第15期1187-1194,共8页Jianli Liu Xuejie Zhang Xiaofeng Wang Li Xu Jingyuan Li Xiaohong Fang 
supported by the National Basic Research Program of China (2013CB933701, 2013CB933704);the National Natural Science Foundation of China (21127901)
Exposure to cigarette smoke is a major risk factor for cancer and cardiovascular disease. Thrombosis is regarded as the main reason for smoking-related car- diovascular disease. However, the detail mechanism of how sm...
关键词：Cigarette carcinogens THROMBIN THROMBOMODULIN AFM Single-molecule forcespectroscopy Molecular simulation 
Super-resolution imaging and tracking of TGF-β receptor II on living cells被引量：3
《Science Bulletin》2016年第8期632-638,共7页Zi Ye Nan Li Libo Zhao Yahong Sun Hefei Ruan Mingliang Zhang Jinghe Yuan Xiaohong Fang 
supported by the National Basic Research Program of China(2013CB933701);the National Natural Science Foundation of China(21127901;91413119;91213305);the Chinese Academy of Science
Single-particle tracking photoactivated local- ization microscopy （sptPALM） has recently emerged as a powerful tool for high-density imaging and tracking of individual molecules in living cells. In this work, we hav...
关键词：Single-particle tracking Photoactivatedlocalization microscopy - Single-moleculefluorescence imaging TGF-β receptor II Membranediffusion 
Yin Yang 1(YY1) synergizes with Smad7 to inhibit TGF-β signaling in the nucleus被引量：11
《Science China(Life Sciences)》2014年第1期128-136,共9页YAN XiaoHua PAN Jun XIONG WanWan CHENG MinZhang SUN YingYuan ZHANG SuPing CHEN YeGuang 
supported by the National Natural Science Foundation of China(91019003);National Basic Research Program of China(2011CB943803 and 2013CB933701)
As a prototype of the TGF-β superfamily cytokines, TGF-β is well known for its diverse roles in embryogenesis and adult tis- sue homeostasis. TGF-β evokes cellular responses by signaling mainly through cell membran...
关键词：TGF-Β SMAD7 YY1 HDAC1 signaling regulation transcriptional co-repressor 
Nanoscale imaging with an integrated system combining stimulated emission depletion microscope and atomic force microscope被引量：10
《Chinese Science Bulletin》2013年第33期4045-4050,共6页YU JianQiang YUAN JingHe ZHANG XueJie LIU JianLi FANG XiaoHong 
supported by the National Basic Research Program of China(2013CB933701);the National Natural Science Foundation of China(91213305,21127901,21121063);Chinese Academy of Sciences
We have built an integrated imaging system by combining stimulated emission depletion(STED)microscope and atomic force microscope(AFM).The STED microscope was constructed based on the supercontinuum fiber laser and a ...
关键词：原子力显微镜 成像系统 集成系统 受激发射 纳米级 损耗 光纤激光器 横向分辨率 
Membrane nanotubes:Novel communication between distant cells被引量：5
《Science China(Life Sciences)》2013年第11期994-999,共6页ZHANG JiangHui ZHANG YouYi 
supported by the National Basic Research Program of China(2013CB933701);the Projects of International Cooperation and Exchanges of the National Natural Science Foundation of China(30910103902);the National Natural Science Foundation of China(81270159)
The many kinds of cell structures involved in cell-cell communication include tight junction,adherens junction and gap junction,but almost all are between adjacent cells.Recently,a general and dynamic membrane tether,...
关键词：membrane nanotubes MICROSTRUCTURE physiological functions cell communication 
新型远距离细胞连接结构——膜纳米管被引量：1
《中国科学：生命科学》2013年第9期713-718,共6页张江晖 张幼怡 
国家重点基础研究发展计划(批准号:2013CB933701);国家自然科学基金国际合作与交流项目(批准号:30910103902);国家自然科学基金(批准号:81270159)资助
与细胞间讯息传递相关的细胞结构有紧密连接、黏附连接和缝隙连接,但它们都只能在紧密相连的细胞间发挥作用.最近,人们发现了一种能够介导距离较远的细胞间讯息传递的膜系结构,称之为隧道纳米管或膜纳米管.膜纳米管通过促进细胞通讯影...
关键词：膜纳米管 微结构 生理功能 细胞通讯 
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