国家重点基础研究发展计划(2006CB500702)

作品数:6被引量:11H指数:2
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相关作者:朱明伟王鲁宁孙虹管锦群吴卫平更多>>
相关机构:中国人民解放军总医院更多>>
相关期刊:《Acta Pharmacologica Sinica》《中华内科杂志》《中国现代神经疾病杂志》更多>>
相关主题:DIFFERENTIATION阿尔茨海默病脑老化脑淀粉样血管病帕金森病更多>>
相关领域:生物学医药卫生更多>>
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脑老化及相关神经疾病新进展被引量:5
《中国现代神经疾病杂志》2014年第3期161-169,共9页朱明伟 王鲁宁 
国家重点基础研究发展计划(973计划)项目(项目编号:2006CB500702)~~
与脑老化相关的主要疾病包括阿尔茨海默病、帕金森病及淀粉样脑血管病。随着人口老龄化趋势的进展,此类疾病已经成为危害我国老年人群健康的重大疾病之一。尽管,目前脑老化机制及相关神经疾病的发病原因尚不十分清楚,但其蛋白质变性、...
关键词:衰老  阿尔茨海默病 帕金森病 脑淀粉样血管病 病理学 综述 
临床病理讨论第427例——双手不自主抖动10年,行动迟缓5年,伴智能减退4年被引量:1
《中华内科杂志》2013年第7期621-623,共3页朱明伟 管锦群 孙虹 吴卫平 
本例组织病理学所用蛋白质抗体受王鲁宁教授国家973课题(2006CB500702)经费资助
病历摘要患者男,90岁。因“双手不自主抖动8年,动作缓慢3年,智能减退2年”于2009年6月10日入院。患者于2001年9月开始出现双手不自主抖动,在紧张及肢体活动时明娃,但自觉不影响日常生活。曾到神经科门诊就诊,当时神经系统检查:...
关键词:临床病理讨论 智能减退 双手 行动迟缓 神经系统检查 简易精神状态 门诊就诊 2009年 
A novel computational method for protein-protein interaction networks prediction of alpha-synuclein被引量:1
《Journal of Shanghai University(English Edition)》2008年第6期501-507,共7页谢江 张武 梅健 顾知立 吴继宗 李辉 张律文 
supported by the National Basic Research Program of China (Grant No.2006CB500702);the Shanghai Lead-ing Academic Discipline Project (Grant No.J50103);Shanghai University Systems Biology Reasearch Funding (GrantNo.SBR08001)
Alpha-synuclein plays an important role in Parkinson's disease(PD).The current study of alpha-synuclein mainly concentrates at the gene level.However, it is found that the study at the protein level has special signif...
关键词:protein-protein interactions (PPIs) ALPHA-SYNUCLEIN heterogeneous data integration computational prediction 
Evaluating effects of gypenosides and soyasaponins on differentiation of neural stem cells as an in vitro model被引量:4
《Journal of Shanghai University(English Edition)》2008年第1期91-94,共4页吴婕 文铁桥 
Project supported by the National Basic Research Program of China (Grant No.2006CB500702), the National Natural Science Foundation of China (Grant No.30570590), and the Science Foundation of Shanghai Municipal Commission of Science and Technology (Grant No.03JC14030)
Neural stem cell has a potential to differentiate into neurons, astrocytes and oligodendrocytes. It provides an in vitro model to screen herbal medicines on the cellular differentiation and development level. In this ...
关键词:neural stem cell GYPENOSIDES SOYASAPONINS herbal medicine in vitro model 
G protein-coupled inwardly rectifying potassium channels in dorsal root ganglion neurons
《Acta Pharmacologica Sinica》2007年第2期185-190,共6页Xiao-fei GAO Hai-lin ZHANG Zhen-dong YOU Chang-lin LU Cheng HE 
the National Natural Science Foundation of China (No 30370454,30325022 and 30530240);the National Key Basic Research Program (No_ 2006CB500702);Program for Changjiang Scholars and Inno-vative Research Team in University;Shanghai Metropolitan Fund for Research and Development (No 04DZ14005 and 04XD14004).
Aim: G protein-coupled inwardly rectifying potassium channels (GIRK) are important for neuronal signaling and membrane excitability. In the present study, we intend to find whether GIRK channels express functionall...
关键词:GIRK DRG neuron G protein coupled receptors potassium channels 
Apium graveolens L. accelerating differentiation of neural stem cells in vitro
《Journal of Shanghai University(English Edition)》2006年第1期89-94,共6页文铁桥 陆伟 陈付学 宋红生 赵翠萍 余涛 
ProjectsupportedbyNationalBasicResearchProgramofChina(GrantNo.2006CB500702),NationalNaturalScienceFounda-tionofChina(GrantNo.30570590),ShanghaiMunicipalCommis-sionofScienceandTechnologyBasicResearchFunds(GrantNos.03JC14030,03JC14061),andScientificResearchFounda-tionfortheReturnedOverseasChineseScholarsofStateEduca-tionMinistry(GrantNo.JWSL2003406)
To evaluate the action of Apium graveolens L. on the growth and differentiation of neural stem cells (NSCs), cells culture and animal experiment were performed. NSCs were isolated from the striatum of SD rat embryo ...
关键词:neural stem cells Apium graveolens L. DIFFERENTIATION proliferation. 
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