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作品数：28被引量：222H指数：6
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Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1被引量：1
《Acta Pharmacologica Sinica》2023年第6期1227-1237,共11页Li-hua Zhao Qing-ning Yuan An-tao Dai Xin-heng He Chuan-wei Chen Chao Zhang You-wei Xu Yan Zhou Ming-wei Wang De-hua Yang H.Eric Xu 
supported by National Natural Science Foundation of China(32071203 to LHZ;82073904 to MWW,81973373 to DHY);the National Key R&D Program of China(2019YFA0904200);the Young Innovator Association of CAS(2018325 to LHZ)and SA-SIBS Scholarship Program to LHZ and DHY;Ministry of Science and Technology(China)grants(2018YFA0507002 to HEX,2018YFA0507000 to MWW);the Shanghai Municipal Science and Technology Major Project(2019SHZDZX02 to HEX;18ZR1447800 to LHZ,21JC1401600 to DHY);the CAS Strategic Priority Research Program(XDB08020303 to HEX).
Parathyroid hormone(PTH)and PTH-related peptide(PTHrP)are two endogenous hormones recognized by PTH receptor-1(PTH1R),a member of class B G protein-coupled receptors(GPCRs).Both PTH and PTHrP analogs including teripar...
关键词：G protein-coupled receptors parathyroid hormone PTH-related peptide PTH receptor-1 cryo-electron microscopy structure OSTEOPOROSIS 
Lymphocyte integrins mediate entry and dysregulation of T cells by SARS-CoV-2被引量：1
《Signal Transduction and Targeted Therapy》2023年第3期916-920,共5页Mengwen Huang Xingchao Pan Xinling Wang Qingfei Ren Bei Tong Xianchi Dong Gaoxiang Ge Lu Lu Shibo Jiang Jianfeng Chen 
This research was supported by the National Key R&D Program of China(2020YFA0509000 to J.C.);the National Natural Science Foundation of China(32030024,31830112,and 31525016 to J.C.,92169112 and 82161138002 to S.J.);Program of Shanghai Academic Research Leader(19XD1404200);Shanghai Municipal Science and Technology Major Project(ZD2021CY001 to S.J);National Ten Thousand Talents Program.The authors gratefully acknowledge the support of the SA-SIBS scholarship program.
Dear Editor,T-cell infection by SARS-CoV-2 and associated immune responses are correlated with disease severity and prognosis of COVID-19.Lymphopenia is associated with increased disease severity in COVID-19.Significa...
关键词：SEVERITY infection prognosis 
Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists
《Acta Pharmacologica Sinica》2023年第2期421-433,共13页Sanaz Darbalaei Ru-lue Chang Qing-tong Zhou Yan Chen An-tao Dai Ming-wei Wang De-hua Yang 
supported by National Natural Science Foundation of China 81872915(MWI),82073904(MW),82121005(DY),81973373(DY),21704064(QZ);National Science&Technology Major Project of China-Key New Drug Creation and Manufacturing Program 2018ZX09735-001(MW),2018ZX09711002-002-005(DY);National Science&Technology Major Project of China-Innovation 2030 for Brain Science and Brain-Inspired Technology 2021ZD0203400(QZ);the National Key Basic Research Program of China 2018YFA0507000(MW);Novo Nordisk-CAS Research Fund grant NNCAS-2017-1-CC(DY)and SA-SIBS Scholarship Program(IDY).
The paradigm of one drug against multiple targets,known as unimolecular polypharmacology,offers the potential to improve efficacy while overcoming some adverse events associated with the treatment.This approach is bes...
关键词：glucagon-like peptide-1 receptor glucagon receptor dual and triple agonist cAMP PERK1/2 unimolecular polypharmacology 
Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors
《Acta Pharmacologica Sinica》2022年第6期1453-1460,共8页Yu-zhe Wang De-hua Yang Ming-wei Wang 
This work was partially supported by National Natural Science Foundation of China 81872915(MWW),82073904(MWW),81773792(DHY)and 81973373(DHY);National Science and Technology Major Project of China–Key New Drug Creation and Manufacturing Program 2018ZX09735–001(MWW)and 2018ZX09711002–002–005(DHY);the National Key Basic Research Program of China 2018YFA0507000(MWW);Novo Nordisk-CAS Research Fund grant NNCAS-2017–1-CC(DHY);SA-SIBS Scholarship Program(DHY).
Glucagon-like peptide-1(GLP-1)and glucose-dependent insulinotropic polypeptide(GIP)are regarded as‘incretins’working closely to regulate glucose homeostasis.Unimolecular dual and triple agonists of GLP-1R and GIPR h...
关键词：glucagon-like peptide-1 receptor glucose-dependent insulinotropic peptide receptor peptide 19 LY3298176 heteromerization type 2 diabetes 
GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis被引量：2
《Acta Pharmacologica Sinica》2022年第5期1156-1166,共11页Yan Chen Ying-na Xu Chen-yu Ye Wen-bo Feng Qing-tong Zhou De-hua Yang Ming-wei Wang 
This work was partially supported by National Natural Science Foundation of China 81872915(MWW),82073904(MWW),81773792(DHY),81973373(DHY),and 21704064(QTZ);National Science&Technology Major Project of China–Key New Drug Creation and Manufacturing Program 2018ZX09735–001(MWW)and 2018ZX09711002–002–005(DHY);the National Key Basic Research Program of China 2018YFA0507000(MWW);Science and Technology Commission of Shanghai Municipality 18431907100(MWW);Novo Nordisk-CAS Research Fund grant NNCAS-2017–1-CC(DHY)and SA-SIBS Scholarship Program(DHY).
Nonalcoholic steatohepatitis(NASH),as a severe form of nonalcoholic fatty liver disease(NAFLD),is characterized by liver steatosis,inflammation,hepatocellular injury and different degrees of fibrosis.The pathogenesis ...
关键词：NAFLD NASH GLP-1R GLP-1 mimetics dual agonists triple agonists GPCR 
Distinct chemokines selectively induce HIV-1 gp120-integrinα4β7 binding via triggering conformer-specific activation ofα4β7
《Signal Transduction and Targeted Therapy》2021年第8期2303-2306,共4页Shu Wang ChangDong Lin Yue Li ZhaoYuan Liu JunLei Wang YouHua Zhang ZhanJun Yan YueBin Zhang GuoHui Li JianFeng Chen 
This work was supported by grants from National Key Research and Development Program of China(2020YFA0509100);National Natural Science Foundation of China(31830112,32030024,31525016 to J.F.C,31970702,31701219 to C.D.L.);Program of Shanghai Academic Research Leader Research Program of the Chinese Academy of Sciences(XDA12010101);the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2020266);the Young Elite Scientist Sponsorship Program by CAST(2019QNRC001);National Ten Thousand Talents Program.The authors gratefully acknowledge the support of SA-SIBS scholarship program.We thank Prof.Brian Seed and Dr.Slim Sassi(Massachusetts General Hospital,Boston,USA)for providing the codon optimized MN gp120 plasmid.We thank Prof.Lu Lu and Master Miao Cao(Fudan University,Shanghai,China)for providing the plasmids expressing BG505 SOSIP.664,Furin,and PGT145 for the expression and purification of BG505 SOSIP.664 gp140 trimers.(19XD1404200);Personalized Medicines-Molecular Signature-based Drug Discovery and Development,the Strategic Priority。
Dear Editor,Gut associated lymphoid tissue(GALT)is the principal site where human immunodeficiency virus 1(HIV-1)replicates.CD4^(+) T cells residing in GALT are predominant targets of HIV-1 during the acute phase of i...
关键词：α4β7 acute GP120 
Contribution of phenylpropanoid metabolism to plant development and plant–environment interactions被引量：101
《Journal of Integrative Plant Biology》2021年第1期180-209,共30页Nai-Qian Dong Hong-Xuan Lin 
supported by the grants from National Natural Science Foundation of China (31788103,31630052);the Chinese Academy of Sciences (QYZDY-SSWSMC023, XDB27010104, 159231KYSB20200008);the Ministry of Science and Technology of China (2016YFD0100902);the Shanghai Science and Technology Development(18JC1415000);the support of the SA-SIBS scholarship program。
Phenylpropanoid metabolism is one of the most important metabolisms in plants, yielding more than 8,000 metabolites contributing to plant development and plant-environment interplay.Phenylpropanoid metabolism material...
关键词：FLAVONOIDS LIGNIN metabolic flux PHENYLPROPANOID secondary metabolites 
Polyoxygenated anti-inflammatory biscembranoids from the soft coral Sarcophyton tortuosum and their stereochemistry被引量：1
《Chinese Chemical Letters》2021年第1期271-276,共6页Yufen Li Songwei Li Cristina Cuadrado Chenglong Gao Qihao Wu Xiaolu Li Tao Pang Antonio Hernandez Daranas Yuewei Guo Xuwen Li 
financially supported by the National Natural Science Foundation of China(NSFC,Nos.81991521,8202290170,42076099);the NSFC/CNRS(Centre National de la Recherche Scientifique)Joint Project(No.81811530284);the National Key Research and Development Program of China(No.2018YFC0310903);the SKLDR/SIMM Project(No.SIMM1903ZZ-04);the Shanghai Rising-Star Program(No.20QA1411100);SA-SIBS Scholarship Program。
Five novel biscembranoids,ximaolides H-L(1-5),along with four known related compounds(6-9) were isolated from the Hainan soft coral Sarcophyton tortuosum.The structures of the new compounds were determined by extensiv...
关键词：Soft coral Sarcophyton tortuosum Biscembranoid STEREOCHEMISTRY ANTI-INFLAMMATORY 
A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor被引量：5
《Cell Research》2020年第12期1098-1108,共11页Wen Sun Li-Nan Chen Qingtong Zhou Li-Hua Zhao Dehua Yang Huibing Zhang Zhaotong Cong Dan-Dan Shen Fenghui Zhao Fulai Zhou Xiaoqing Cai Yan Chen Yan Zhou Sarina Gadgaard Wijnand JCvan der Velden Suwen Zhao Yi Jiang Mette MRosenkilde HEric Xu Yan Zhang Ming-Wei Wang 
the National Natural Science Foundation of China(81872915(M.W.W.),81922071(Y.Zhang),81773792(D.Y.),81973373(D.Y.),21704064(Q.Z.),31770796(YJ.)and 31971178(S.Z.));the National Science&Technology Major Project of China—Key New Drug Creation and Manufacturing Program(2018ZX09735-001(M.W.W.),2018ZX09711002-002-005(D.Y.)and 2018ZX09711002-002-002(YJ.));the National Key Basic Research Program of China(2018YFA0507000(M.W.W.and S.Z.)and 2019YFA0508800(Y.Zhang));the Shanghai Municipal Science and Technology Major Project(2019SHZDZX02(H.E.X.));the Ministry of Science and Technology of China Major Project(XDB08020303(H.E.X.));Zhejiang Province Science Fund for Distinguished Young Scholars(LR19H310001(Y.Zhang));Fundamental Research Funds for Central Universities(2019XZZX001-01-06(Y.Zhang));Shanghai Science and Technology Development Fund(18ZR1447800(L.H.Z.));Young Innovator Association of CAS(2018325(L.H.Z.));SA-SIBS Scholarship Program(L.H.Z.and D.Y.);Fudan-SIMM Joint Research Fund(FU-SIMM-20174003(L.H.Z.and M.W.W.))and Novo Nordisk-CAS Research Fund grant(NNCAS-2017-1-CC(D.Y.)).
Glucagon-like peptides(GLP-1 and GLP-2)are two proglucagon-derived intestinal hormones that mediate distinct physiological functions through two related receptors(GLP-1R and GLP-2R)which are important drug targets for...
关键词：SPECIFICITY SPITE INSIGHT 
Structural insights into the activation of GLP-1R by a small molecule agonist被引量：2
《Cell Research》2020年第12期1140-1142,共3页Honglei Ma Wei Huang Xiaoxi Wang Lihua Zhao Yi Jiang Feng Liu Wei Guo Xianqiang Sun Wenge Zhong Daopeng Yuan HEric Xu 
by the Ministry of Science and Technology(China)grants(2018YFA0507002 to H.E.X.);Shanghai Municipal Science and Technology Major Project(2019SHZDZX02 to H.E.X.);CAS Strategic Priority Research Program(XDB08020303 to H.E.X.);Shanghai Science and Technology Committee(19ZR1467500 to H.M.);the Young Innovator Association of CAS(H.M.);SA-SIBS Scholarship Program(L.Z.),the Young Innovator Association of CAS(2018325 to L.Z.);the National Natural Science Foundation of China(31770796 to YJ.);the National Science&Technology Major Project"Key New Drug Creation and Manufacturing Program"(2018ZX09711002 to Y.J.);the K.C.Wong Education Foundation(YJ.).
Dear Editor,The glucagon-like peptide-1 receptor(GLP-1R)belongs to class B G protein-coupled receptors(GPCRs).It is a clinically proven target for type 2 diabetes and obesity.1 Several peptidic drugs have been approve...
关键词：INSIGHT belongs ACTIVATION 
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