国家自然科学基金(81272468)

作品数：6被引量：9H指数：2
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相关作者：余四旺阙琳玲曹宝山王夔王永瑞更多>>
相关机构：北京大学北京大学第三医院南京医科大学更多>>
相关期刊：《Journal of Chinese Pharmaceutical Sciences》《肿瘤》更多>>
相关主题：NRF2STUDYSTRUCTURE-ACTIVITYPRELIMINARYLICORICE更多>>
相关领域：医药卫生更多>>
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Nrf2激动剂干预肿瘤化疗药物毒性的研究进展
《肿瘤》2020年第11期801-808,共8页王婧亚 阙琳玲 何柳 贾兆君 徐江丽 余四旺 
国家自然科学基金(编号:81472657,81272468);中国博士后科学基金(编号:2018M641116)。
化疗是肿瘤治疗中最重要的手段之一,但其疗效和应用受限于肿瘤组织的耐药性及对正常组织的毒性。红系衍生的核因子2相关因子2(nuclear factor erythroid-derived 2-related factor 2,Nrf2)是调控细胞抗氧化响应和药物代谢的核心转录因子...
关键词：肿瘤 药物疗法 药物相关性副作用和不良反应 抗药性 肿瘤 
Nrf2/ARE signaling protects against oxaliplatin-induced hepatotoxicity in mice被引量：2
《Journal of Chinese Pharmaceutical Sciences》2017年第10期709-718,共10页何柳 徐江丽 郭丽梅 阙琳玲 尹文琤 曹宝山 余四旺 
National Natural Science Foundation of China(Grant No.81272468,81372266,91429305 and 21001011);WU JIEPING Medical Foundation(Grant No.320.6750.12196)
Nuclear factor erythroid 2-related factor 2 （Nrf2） controls the expression of a wide array of antioxidant response element （ARE）-driven genes, which are involved in stress response and metabolism regulation. The r...
关键词：NRF2 OXALIPLATIN HEPATOTOXICITY Nrf2-/- mice 
Prenylated flavonoids from Glycyrrhiza uralensis as promising anti-cancer agents: a preliminary structure-activity study被引量：7
《Journal of Chinese Pharmaceutical Sciences》2016年第1期23-29,共7页唐叔南 黄维 季帅 王永瑞 裴道勇 叶敏 余四旺 
National Natural Science Foundation of China(Grant No.81472657 and 81272468)
Prenylated flavonoids are mainly distributed in Leguminosae and Moraceae plants, and they have been reported to possess various biological activities. Previously, we have reported a prenylated isoflavonoid, isoangusto...
关键词：Prenylated flavonoids LICORICE ANTI-CANCER Structure-activity relationship 
Metformin activates Nrf2 signaling and induces the expression of antioxidant genes in skeletal muscle and C2C12 myoblasts
《Journal of Chinese Pharmaceutical Sciences》2014年第12期837-843,共7页杨思敏 姬利延 阙琳玲 王夔 余四旺 
National Natural Science Foundation(Grant No.812 72468 and 81472657);the Scientific Research Foundation for the Returned Overseas Chinese Scholars,Ministry of Education
As a first line anti-diabetes drug, the molecular mechanisms by which metformin exerts its pharmacological activities are still under extensive investigations. The Nrf2 signaling plays a crucial role in protecting cel...
关键词：METFORMIN AMPK NRF2 Antioxidant response Skeletal muscle 
IC5, a dithiocarbamate derivative, inhibits colon cancer cell proliferation in vitro and colitis-associated colorectal carcinogenesis in vivo
《Journal of Chinese Pharmaceutical Sciences》2014年第9期610-616,共7页马婉婉 唐叔南 曹明楠 葛泽梅 李润涛 余四旺 
National Natural Science Foundation(Grant No.81272468 and 21001011);the Scientific Research Foundation for the Returned Overseas Chinese Scholars,Ministry of Education
Colorectal cancer （CRC） is one of the leading causes of cancer-related deaths, and inflammatory bowel diseases and dysregulated cell proliferation play important roles in colorectal carcinogenesis. Therefore, inhibi...
关键词：DITHIOCARBAMATE Colorectal cancer Colitis-associated colorectal carcinogenesis CHEMOPREVENTION Proliferation NF-KB 
Upregulation of Nrf2-regulated gene expression by tBHQ alleviates cyclophosphamide-induced hematotoxicity in mice
《Journal of Chinese Pharmaceutical Sciences》2014年第1期39-45,共7页阙琳玲 王欣竹 钱鹏展 曹宝山 王夔 余四旺 
National Natural Science Foundation(Grant No.81272468 and 21001011);the Scientific Research Foundation for the Returned Overseas Chinese Scholars,Ministry of Education
Hematological toxicity （bone marrow suppression） is the most common dose-limiting adverse effect of chemotherapies. The nuclear factor erythroid 2-related factor 2 （Nrf2） is a pivotal coordinator of cellular defen...
关键词：CYCLOPHOSPHAMIDE HEMATOTOXICITY Peripheral blood cells Bone marrow TBHQ NRF2 
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