国家自然科学基金(81173110)

作品数：7被引量：27H指数：3
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相关作者：杨为民杜晓华李佳勋杨为民赵继坤更多>>
相关机构：昆明医科大学更多>>
相关期刊：《Chinese Herbal Medicines》《Chinese Journal of Natural Medicines》《昆明医科大学学报》《Natural Products and Bioprospecting》更多>>
相关主题：SCUTELLARINPKGREOXYGENATIONHYPOXIA病理机制更多>>
相关领域：医药卫生生物学更多>>
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Scutellarin Reduces Cerebral Ischemia Reperfusion Injury Involving in Vascular Endothelium Protection and PKG Signal被引量：2
《Natural Products and Bioprospecting》2021年第6期659-670,共12页Ya-Juan Chen Chen Chen Meng-Yuan Li Qing-Qing Li Xiu-Juan Zhang Rong Huang Xing-Wei Zhu Chun-Yun Bai Liu-Yi Zhang Pei-Hua Peng Wei-Min Yang 
the National Natural Science Foundation of China(Nos.81560589,30960450,81173110 and 81560072);Yunnan Provincial Science and Technology Department(Nos.202105AF150015,202102AA310030,2018FE001(-026),2017FE467(-019),2014BC012,and 2017IC041);Yunnan Provincial Educational Department(Nos.2018JS161).
Flavonoid glycoside scutellarin(SCU)has been widely applied in the treatment of cerebral ischemic diseases in China.In this article,we conducted research on the working mechanisms of SCU in hypoxia reoxygenation(HR)in...
关键词：SCUTELLARIN Basilar artery Vascular endothelium Ischemia reperfusion PKG 
Scutellarin protects human cardiac microvascular endothelial cells with hypoxia-reoxygenation injury via JAK2/STAT3 signal pathway被引量：2
《Chinese Herbal Medicines》2019年第1期103-107,共5页Chen Chen Zhi-ying Weng You-lan Wang Chang-bo Zheng Yang Li Jian Yang Ze-lan Dai Bai-xi Ji Chuang Xiao Wei-min Yang 
funded by the National Natural Science Foundation of China(Grant No.30960450,No.81560589,and No.81173110);Yunnan Province Science and Technology Department and Education Department(Grant No.2017FE467(-019),No.2018JS161,No.2014FA010,No.ZD2015009);Yunnan–USA joint research center of molecular medicines(No.2015ID001)
Objective: To investigate the antagonistic cell injury effect and molecular mechanism of scutellarin(SCU)in hypoxia reoxygenation(HR) treated human cardiac microvascular endothelial cells(HCMECs).Methods: The method o...
关键词：cell VIABILITY HCMECs hypoxia REOXYGENATION JAK2-STAT3 pathway MDA SCUTELLARIN 
Protective effects of scutellarin on vascular dysfunction caused by hypertension in SHR rats
《中国药理学与毒理学杂志》2015年第S1期32-32,共1页Qing-qingLI Zhi-yingWENG MinZHANG ChenCHEN Xiao-huaDU Pei-huaPENG Wen-juanWU JunZHANG Wei-minYANG 
The project supported by National Natural Science Foundation of China(81173110,81373964,81402991);Yunnan Provincial Science and Technology Department(2011FA022,2014FA010,2014IA033and 2014BC012)
OBJECTIVE To investigate the effect of scutellarin(SCU),which is the main effective component of Erigeron breviscapus(Vant.)Hand-Mazz native to Yunnan in China,on vascular dysfunction(VD)of cardiac coronary artery(CA)...
关键词：SCUTELLARIN SHR CORONARY ARTERY BASILAR ARTERY VAS 
Effects of scutellarin on PKG in HCMECs after hypoxia roxygenation
《中国药理学与毒理学杂志》2015年第S1期33-34,共2页YangLI Zhi-yingWENG MinZHANG ChenCHEN Xiao-huaDU Pei-huaPENG Wen-juanWU XuanLIU Wei-minYANG 
The project supported by National Natural Science Foundation of China(30960450,81373964,81173110and 81402991);Yunnan Provincial Science and Technology Department(2011FA022,2014FA010,2014IA033and 2014BC012);Shanghai Science&Technology Support Program(13431900401);National Science&Technology Major Project of China(2014ZX09301-306-03)
OBJECTIVE This study discusses the effects of scutellarin(SCU),which is one of effective component of Erigeron breviscapus(Vant.)Hand-Mazz,on cGMP dependent protein kinase(PKG)in human cardiac microvascular endothelia...
关键词：SCUTELLARIN HYPOXIA roxygenation PKG HUMAN CARDIAC 
Scutellarin attenuates endothelium-dependent aasodilation impairment induced by hypoxia reoxygenation, through regulating the PKG signaling pathway in rat coronary artery被引量：6
《Chinese Journal of Natural Medicines》2015年第4期264-273,共10页CHEN Ya-Juan WANG Lei ZHOU Guang-Yu YU Xian-Lun ZHANG Yong-Hui HU Na LI Qing-Qing CHEN Chen QING Chen LIU Ying-Ting YANG Wei-Min 
supported by the National Natural Science Foundation of China(Nos.30960450,81173110);Yunnan Provincial Science and Technology Department(Nos.2011FA 022,2012BC012,2014FA010,2014FB037,2014BC012)
Scutellarin(SCU), a flavonoid from a traditional Chinese medicinal plant. Our previous study has demonstrated that SCU relaxes mouse aortic arteries mainly in an endothelium-depend-ent manner. In the present study, we...
关键词：SCUTELLARIN Endothelium-dependent vasodilation Hypoxia reoxygenation c GMP-dependent protein kinase RAT Coronary artery 
缺血性脑卒中的病理机制及药物研究进展被引量：12
《医学信息（医学与计算机应用）》2014年第11期538-539,共2页马聪吉 杜晓华 杨为民 
国家自然科学基金项目(30960450,81173110);云南省科技厅应用基础重点项目(2011FA022);重点新产品开发计划项目(2012BC012)资助。
缺血性脑卒中已成为威胁人类健康的重要因素,其发病率和死亡率呈不断上升趋势,因此探讨缺血性脑卒中的发病机理及其药物研究,对于预防和治疗该病具有重要的意义。本文阐述了缺血性脑卒中的发病机制及治疗药物的研究进展。
关键词：缺血性脑卒中 发病机制 治疗药物 
佛司可林及异佛司可林的一般药理学初步研究被引量：5
《昆明医科大学学报》2014年第7期37-40,共4页赵继坤 杨为民 杨之斌 李佳勋 付健健 
国家自然科学基金资助项目(81173110);云南省科技厅重点新产品开发计划项目(2012BC012)
目的观察佛司可林(forskolin,FSK)、异佛司可林(isoforskolin,ISOF)对SD大鼠的心血管系统、呼吸系统的影响.方法 (1)将50只SD大鼠按雌雄各半随机分为5个处理组,即对照组(Control)、FSK及ISOF低、高剂量组(2、6 mg/kg),每组n=10.(2)动物...
关键词：佛司可林 异佛司可林 一般药理学 
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