国家自然科学基金(81321003)

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细胞分裂周期相关蛋白7通过增强细胞增殖和干性促进人乳腺癌进程被引量：2
《解剖学报》2020年第6期888-896,共9页杨得草 刘程 马集 王梦远 战军 张宏权 
国家自然科学基金(81230051,81472734,31170711,81321003,81773199,30830048);科技部专项基金(2016YFC1302103,2015CB553906);北京市自然科学基金(7120002)。
目的探讨细胞分裂周期相关蛋白7(CDCA7)在人类乳腺癌中的相关功能及潜在的作用机制。方法通过癌症和肿瘤基因图谱(TCGA)数据库分析检索出不同乳腺癌亚型差异表达基因,找到在基底型乳腺癌中高表达基因,在这些基因中找到CDCA7,通过临床患...
关键词：细胞分裂周期相关蛋白7 Basal-like/luminal乳腺癌 干细胞 Β-连环蛋白 流式细胞术 人 
C1orf106, an innate immunity activator, is amplified in breast cancer and is required for basal-like/luminal progenitor fate decision被引量：2
《Science China(Life Sciences)》2019年第9期1229-1242,共14页Ji Ma Cheng Liu Decao Yang Jiagui Song Jing Zhang Tianzhuo Wang Mengyuan Wang Weizhi Xu Xueying Li Shigang Ding Jun Zhan Hongquan Zhang 
supported by the Ministry of Science and Technology of China (2016YFC1302103 and 2015CB553906);the National Natural Science Foundation of China (81230051, 81472734,31170711, 81321003, and 30830048);the Beijing Natural Science Foundation (7120002);the 111 Project of the Ministry of Education, Peking University (BMU2018JC004, BMU20120314, and BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau to H.Z;a grant from the National Natural Science Foundation of China (81773199) to J.Z
Basal-like breast cancer with a luminal progenitor gene expression profile is an aggressive subtype of breast cancer with a poorer prognosis compared with other subtypes.However,genes that specifically promote basal-l...
关键词：C1orf106 BASAL-LIKE LUMINAL PROGENITOR breast cancer ELF5 GATA3 
G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma被引量：2
《Frontiers of Medicine》2019年第4期482-491,共10页Wenjing Wang Shigang Ding Hejun Zhang Jun Li Jun Zhan Hongquan Zhang 
This study was supported by grants from the Ministry of Science and Technology ofChina (Nos. 2016YFC1302103,2015CB553906, and 2013CB910501);the National Natural Science Foundation of China (Nos. 81230051, 81472734, 31170711, 81321003, and 30830048);the Beijing Natural Science Foundation (No. 7120002);the 111 Project of the Ministry of Education, Peking University (Nos. BMU20120314 and BMU20130364);and the Leading Academic Discipline Project of Beijing Education Bureau to Hongquan Zhang.
LGR6 is a member of the G protein-coupled receptor family that plays a tumor-suppressive role in colon cancer. However, the relationship between LGR6 expression in patients and clinicopathological factors remains uncl...
关键词：LGR6 COLON ADENOCARCINOMA IMMUNOHISTOCHEMISTRY PROGNOSIS 
Kindlin-1和Kindlin-2的差异表达与食管癌的进程及流行病学特点的相关性被引量：3
《中国科学：生命科学》2018年第1期93-101,共9页王鹏 战军 宋佳桂 王允玲 方伟岗 刘芝华 张宏权 
中国科技部基金(批准号：2016YFC1302103,2015CB553906,2013CB910501); 国家自然科学基金(批准号：81230051,81472734,31170711,81321003,81301802,30830048); 北京自然科学基金(批准号：7120002); 北京大学教育部111项目(批准号：BMU20120314,BMU20130364); 北京教育局领导学科项目资助
食管癌是中国最致命的恶性肿瘤之一,但其病因和危险因素的分子机制仍不清楚.整合素相互作用蛋白Kindlin-1和Kindlin-2可以激活跨膜受体整合素,调节肿瘤细胞的生长、侵袭和转移.本研究首次发现,在中国食管癌患者中,Kindlin-1和Kindlin-2...
关键词：Kindlin-1 Kindlin-2 食管癌 流行病学 
Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology被引量：1
《Science China(Life Sciences)》2017年第11期1214-1222,共9页peng wang jun zhan jiagui song yunling wang weigang fang zhihua liu hongquan zhang 
supported by the Ministry of Science and Technology of China (2016YFC1302103, 2015CB553906. 2013CB910501);the National Natural Science Foundation of China (81230051, 81472734, 31170711, 81321003, 81301802, 30830048);Beijing Natural Science Foundation (7120002);the 111 Project of the Ministry of Education, Peking University (BMU20120314, BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau to Hongquan Zhang
Esophageal cancer （EC） is one of the most lethal malignancies in China, but the etiology and risk factors remain unclear. The integrin-interacting proteins Kindlin-1 and Kindlin-2 are focal adhesion molecules that a...
关键词：Kindlin-l Kindlin-2 esophageal cancer EPIDEMIOLOGY 
Depletion of Kindlin-2 induces cardiac dysfunction in mice被引量：1
《Science China(Life Sciences)》2016年第11期1123-1130,共8页Lihua Qi Yu Yu Xiaochun Chi Danyu Lu Yao Song Youyi Zhang Hongquan Zhang 
supported by the Ministry of Science and Technology of China(2015CB553906,2013CB910501);the National Natural Science Foundation of China(81500180,81230051,81472734,31170711,81321003,30830048);Beijing Natural Science Foundation(7120002);the 111 Project of the Ministry of Education,Peking University(BMU20120314,BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau to Hongquan Zhang
Kindlin-2, a member of the Kindlin family focal adhesion proteins, plays an important role in cardiac development. It is known that defects in the Z-disc proteins lead to hypertrophic cardiomyopathy(HCM) or dilated ca...
关键词：Kindlin-2 depletion myocardial hypertrophy cardiac dysfunction MOUSE 
含有多种酶活性的SIRT5蛋白在细胞代谢中的功能被引量：3
《中国科学：生命科学》2015年第11期1069-1073,共5页杨鑫 刘博雅 朱卫国 罗建沅 
国家自然科学基金(批准号:81321003,81270427,81471405)资助
Sirtuins作为Ⅲ型蛋白质去乙酰化酶调控机体多种生理进程,包括DNA修复、基因组稳定性、能量代谢、衰老以及癌症发生.目前已鉴定出7种人类Sirtuins家族的蛋白(SIRT1–SIRT7),其组织分布、亚细胞定位以及酶作用的底物都不尽相同.本文将着...
关键词：SIRTUINS SIRT5 去乙酰化 去丙二酰化 去琥珀酰化 去戊二酰化 
Kindlin-2 expression in adult tissues correlates with their embryonic origins被引量：8
《Science China(Life Sciences)》2014年第7期690-697,共8页ZHAN Jun YANG Mei CHI XiaoChun ZHANG Jing PEI XueLian REN CaiXia GUO YongQing LIU Wei ZHANG HongQuan 
supported by the National Natural Science Foundation of China (81301802,81230051,30830048,81321003,31170711);Ministry of Science and Technology of China (2013CB910501,2010CB912203,2010CB529402);Program of Introducing Talents of Discipline to Universities of Ministry of Education;Beijing Natural Science Foundation (7120002);Peking University (BMU20120314,BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau
Kindlin-2 functions in the maintenance of homeostasis and in human diseases.This study investigated the interrelationship between Kindlin-2 expression in tissues and the corresponding germ layers from which these tiss...
关键词：Kindlin-2 germinal layers migration EMBRYO 
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