国家自然科学基金(81200264)

作品数：9被引量：97H指数：6
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相关作者：陈红旗秦环龙石忱长杨永志夏阳更多>>
相关机构：上海交通大学附属第六人民医院安徽医科大学同济大学更多>>
相关期刊：《Journal of Ocean University of China》《Science China(Life Sciences)》《中国现代普通外科进展》《World Journal of Pediatrics》更多>>
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Impact of probiotics supplement on the gut microbiota in neonates with antibiotic exposure: an open-label single-center randomized parallel controlled study被引量：2
《World Journal of Pediatrics》2021年第4期385-393,共9页Hui Zhong Xiang-Geng Wang Jing Wang Yan-Jie Chen Huan-Long Qin Rong Yang 
This work was supported by grants from the National Natural Science Foundation of China(Nos.81230057,81200264,81372615,and 81472262);the Emerging Cutting-Edge Technology Joint Research Projects of Shanghai(No.SHDC12012106);the Tongji University Subject Pilot Program(No.162385).
Background Antibiotics,a common strategy used for neonatal infection,show consistent effect on the gut microbiota of neonates.Supplementation with probiotics has become increasingly popular in mitigating the loss of t...
关键词：ANTIBIOTICS Gut microbiota Neonatal infection PROBIOTICS 
Alterations in intestinal microbiota of colorectal cancer patients receiving radical surgery combined with adjuvant CapeOx therapy被引量：9
《Science China(Life Sciences)》2019年第9期1178-1193,共16页Cheng Kong Renyuan Gao Xuebing Yan Linsheng Huang Jide He Hao Li Jie You Huanlong Qin 
supported by the National Natural Science Foundation of China (81230057, 81372615, 81472262 and 81200264);the Emerging Cutting-Edge Technology Joint Research Projects of Shanghai (SHDC12012106);Tongji University Subject Pilot Program (162385);Lijieshou Intestinal Barrier Foundation (LJS-201701);Specialized Research Fund for the Combine Traditional Chinese and Western Medicine in General Hospital of Shanghai (ZHYY-ZXYJHZX-1-201704)
An intricate relationship exists and interactions occur between gut microbiota and colorectal cancer(CRC).Radical surgery combined with adjuvant chemotherapy(AC) serves as the mainstream therapeutic scheme for most CR...
关键词：SURGERY CHEMOTHERAPY INTESTINAL MICROBIOTA COLORECTAL cancer 
Dysbiosis of gut microbiota was closely associated with psoriasis被引量：11
《Science China(Life Sciences)》2019年第6期807-815,共9页Linsheng Huang Renyuan Gao Ning Yu Yefei Zhu Yangfeng Ding Huanlong Qin 
supported by the National Natural Science Foundation of China (81230057, 81200264, 81372615, 81472262);the Emerging Cutting-Edge Technology Joint Research Projects of Shanghai (SHDC12012106);the Tongji University Subject Pilot Program (162385)
Psoriasis is an autoimmune disease and gut microbiota participate in the establishment of intestinal immunity. This study was performed to identify the fecal microbial composition of psoriasis patients, and investigat...
关键词：DYSBIOSIS GUT MICROBIOTA PSORIASIS SEVERITY 
Optimization of Hydrolysis Conditions for the Isolation of Angiotensin-I Converting Enzyme(ACE) Inhibitory Peptides from Rhopilema hispidum被引量：3
《Journal of Ocean University of China》2018年第6期1458-1464,共7页SUN Zhenliang QIN Huanlong CAO Duo YAN Xuebing LI Hao HUANG Linsheng QU Xiao KONG Cheng WANG Man 
supported by the National Natural Science Foundation of China (Nos. 81230057, 81372615, 81472262, 41306133 and 81200264);the Emerging Cutting-Edge Technology Joint Research projects of Shanghai (No. SHDC12012106);the Tongji University Subject Pilot Program (No. 162385);partly funded by the Shanghai Municipal Health and Family Planning Commission Project (Nos. 201540027 and 20174Y0236);the seed fund program of Shanghai University of Medicine & Health Sciences (No. HSMF-17-22-031);Excellent Young Medical Expert of Shanghai (No. 2017YQ048);Shangha Natural Science Foundation (No. 18ZR1431700);China Postdoctoral Science Foundation (No. 2017M610278);the Key Research and Developing Plan of Shandong Province (No. 2015GSF115015)
To obtain the maximum angiotensin-I converting enzyme(ACE) inhibitory activity, the protein hydrolysis conditions of the jellyfish Rhopilema hispidum were optimized using response surface methodology(RSM). Trypsin was...
关键词：Rhopilema hispidum ACE INHIBITORY PEPTIDE response surface methodology protein HYDROLYSATE 
合生元对慢性功能性便秘患者肠道菌群的影响被引量：5
《中华临床营养杂志》2018年第4期228-234,共7页黄林生 严雪冰 李豪 高仁元 沈通一 秦环龙 
国家自然科学基金（81230057、81372615、81472262、81200264）;同济大学学科先导计划（162385）
目的 分析合生元在治疗慢性功能性便秘过程中对肠道菌群的改善情况.方法 根据纳入和排除标准,选取6例慢性功能性便秘患者,留取新鲜粪便,在经过合生元持续治疗1个月后,再次留取粪便.同时选取6名健康志愿者的粪便作为对照组,粪便样本送至...
关键词：便秘 菌群 宏基因组 
Microbial treatment in chronic constipation被引量：49
《Science China(Life Sciences)》2018年第7期744-752,共9页Linsheng Huang Qi Zhu Xiao Qu Huanlong Qin 
supported by the National Natural Science Foundation of China(81230057,81200264,81372615,81472262);the Emerging Cutting-Edge Technology Joint Research Projects of Shanghai(SHDC12012106);the Tongji University Subject Pilot Program(162385)
Chronic functional constipation is a kind of common intestinal disease that occurs in children, adults and elderly people. This disease not only causes great influence to physiological function, but also results in va...
关键词：CONSTIPATION PROBIOTICS PREBIOTICS SYNBIOTICS FMT 
多西他赛或奥沙利铂联合5-氟尿嘧啶治疗晚期胃癌的临床效果研究被引量：6
《中国医学前沿杂志（电子版）》2016年第12期37-41,共5页李晓莉 朱佳 马亚梅 陈红旗 
国家自然科学基金青年科学基金项目(81200264)
目的探讨多西他赛或奥沙利铂联合5-氟尿嘧啶(5-fluorouracil,5-FU)治疗晚期胃癌的近、远期疗效。方法将2010年5月至2015年4月渭南市中心医院收治的116例晚期胃癌患者依据其最终接受的化疗方案不同分为A、B、C三组。A组患者40例,采用多...
关键词：多西他赛 奥沙利铂 5-氟尿嘧啶 胃癌 
乳酸菌对IL-10^(-/-)小鼠肠黏膜屏障损伤修复的机制研究被引量：6
《中国现代普通外科进展》2015年第11期845-850,共6页王忠锐 陈红旗 杨俊 
国家自然科学基金资助项目(81200264)
目的 :评价乳酸菌对IL-10基因敲除(IL-10^(-/-))小鼠肠黏膜损伤的修复作用,初步阐明其作用机制。方法:以IL-10^(-/-)小鼠为模型,益生菌为植物乳杆菌(LP),随机分成对照组(WT组)、IL-10^(-/-)组、IL-10^(-/-)+LP组,分别灌饲Ringer液(WT组...
关键词：益生菌 肠黏膜屏障 内质网应激 炎症性肠病 IL-10基因敲除 
益生菌制剂对结直肠癌患者围手术期的影响被引量：7
《中华临床营养杂志》2014年第2期74-81,共8页陈红旗 夏阳 石忱长 梁勇 杨永志 秦环龙 
基金项目：国家自然科学基金（81200264）
目的探讨酪酸梭菌二联活菌对结直肠癌患者围手术期的影响及其作用机制。方法我院2011年5月至7月共70例限期行结直肠癌手术患者，采用随机数字表法分为试验组（n=35）和对照组（n=35）。两组于术前5d至术后7d每日分别给予酪酸梭菌二联活...
关键词：益生菌制剂 结直肠癌 围手术期 肠屏障功能 肠道菌群 
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