国家重点基础研究发展计划(2011CB606205)

作品数：17被引量：63H指数：4
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相关作者：崔福斋黄继锋李世普王伟莉林莉更多>>
相关机构：清华大学武汉理工大学广州军区武汉总医院东南大学更多>>
相关期刊：《Science Bulletin》《生物骨科材料与临床研究》《Progress in Natural Science:Materials International》《南京医科大学学报（自然科学版）》更多>>
相关主题：CHEMICALCOLLAGEN周围神经缺损神经导管导管修复更多>>
相关领域：医药卫生生物学农业科学一般工业技术更多>>
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Clinical evaluations of mineralized collagen in the extraction sites preservation被引量：25
《Regenerative Biomaterials》2016年第1期41-48,共8页Lu Feng Liang Zhang Yun Cui Tian-Xi Song Zhi-Ye Qiu Xiu-Mei Wang Bao-Sheng Tan 
supported by the National Basic Research Program of China(973 Program,2011CB606205);the‘Twelfth Five-Year’National Science and Technology Support Program(2012BAI17B02);the Ministry of Science and Technology of China and the National Natural Science Foundation of China(Grant Nos.21371106 and 51402167).
The purpose of this study was to explore the different effects between biomimetic mineralized collagen(MC)and ordinary physically blended hydroxyapatite/collagen(HA/Col)composite in evaluating new bone formation and r...
关键词：mineralized collagen BIOMIMETIC extraction site preservation bone formation height 
Biomaterials for reconstruction of cranial defects被引量：1
《Frontiers of Materials Science》2015年第4期346-354,共9页Tao SONG Zhi-Ye QIU Fu-Zhai CUI 
Acknowledgements This work was in part supported by the National Basic Research Program of China （973 Program, 2011CB606205） and the ＇Twelfth Five-Year＇ National Science and Technology Support Program （2012BAI17B02） funded by the Ministry of Science and Technology of China, and the National Natural Science Foundation of China （Grant Nos. 21371106 and 51402167）.
Reconstruction of cranial defect is commonly performed in neurosurgical operations. Many materials have been employed for repairing cranial defects. In this paper, materials used for cranioplasty, including autografts...
关键词：CRANIOPLASTY AUTOGRAFT ALLOGRAFT metallic material BIOCERAMICS mineralized collagen 
PRGD复合神经导管修复上肢周围神经缺损被引量：5
《中华显微外科杂志》2015年第2期130-133,共4页黄继锋 张伟才 王伟莉 林莉 严琼姣 李世普 
国家“973”重点基础研究发展计划资助项目（2011CB606205）;教育部科学技术研究重大项目资助（313041）
目的 探讨应用PRGD复合神经导管桥接修复上肢粗大周围神经缺损的疗效. 方法 2011年12月-2014年8月,应用PRGD复合神经导管桥接修复上肢粗大周围神经缺损的患者19例,其中正中神经和桡神经各6例,尺神经7例.术后定期随访,行感觉、运动功能...
关键词：神经导管 周围神经缺损 修复 上肢 RGD多肽接枝聚(乳酸-羟基乙酸-L-赖氨酸) 
Promotion of peripheral nerve regeneration and prevention of neuroma formation by PRGD/PDLLA/b-TCP conduit:report of two cases被引量：1
《Regenerative Biomaterials》2015年第2期119-124,共6页Yixia Yin Binbin Li Qiongjiao Yan Honglian Dai Xinyu Wang Jifeng Huang Shipu Li 
This work was supported by the National Basic Research Program of China(973 Program,No.2011CB606205);National Natural Science Foundation of China(No.51403168,81190133 and 51172172);Natural Science Foundation of Hubei Province(No.2013CFB354);Key grant Project of Chinese Ministry of Education(No.313041).
In the field of nerve repair,one major challenge is the formation of neuroma.However,reports on both the promotion of nerve regeneration and prevention of traumatic neuroma in the clinical settings are rare in the fie...
关键词：clinical case peripheral nerve regeneration neuroma formation PRGD/PDLLA/b-TCP conduit 
Cytocompatibility Evaluation of Grafted IKVAV PLEOF Hydrogels with Bone Marrow Mesenchymal Stem Cells被引量：1
《Journal of Wuhan University of Technology(Materials Science)》2014年第4期824-831,共8页李宾斌 ZHANG Ping YIN Yixia QIU Tong TAO Yuan WANG Xinyu 李世普 
Funded by theNational Basic Research Program of China(No.2011CB606205);the Self-determined and Innovative Research Funds of WUT(No.2012-YB-007)
The novel hydrogels-grafted IKVAV poly（lactide-co-ethylene oxide-co-fumarate）（PLEOF） hydrogels（GIPHs） were developed. The rat bone marrow mesenchymal stem cells（BMMSCs） were employed, and the cell vitality and...
关键词：proliferation IKVAV hydrogels vitality apoptosis 
Tumor-suppressor effects of chemical functional groups in an in vitro co-culture system
《Frontiers of Materials Science》2014年第2期136-141,共6页Su-Ju xu Fu-Zhai CUI Xiang-Dong KONG 
Acknowledgements This work was in part supported by the National Basic Research Program of China （Grant No. 2011 CB606205）, the National Natural Science Foundation of China （Grant No. 51272236）, and the Program for 521 Excellent Talents ofZhejiang Sci-Tech University.
Liver normal cells and cancer cells co-cultured on surfaces modified by different chemical functional groups, including mercapto （-SH）, hydroxyl （-OH） and methyl （-CHz） groups. The results showed that different ...
关键词：tumor suppressor chemical functional group co-culture system regen-erative medicine material 
彩色多普勒超声对PRGD复合神经导管修复周围神经缺损的评价被引量：5
《华南国防医学杂志》2014年第6期570-572,577,共4页林利 王伟莉 黄继锋 李世普 
国家"973"重点基础研究发展计划资助项目(2011CB606205);教育部科学技术研究重大项目(313041)
目的探讨彩色多普勒超声(color Doppler ultrasound,CDUS)在神经导管桥接修复缺损神经再生临床评价的可行性。方法对10例周围神经缺损患者进行神经导管桥接修复术,并在术后采用超声连续动态观察缺失神经再生生长状况。结果术后每3个月...
关键词：超声 神经导管 周围神经 缺损 
Gene expression profiling and mechanism study of neural stem cells response to surface chemistry被引量：4
《Regenerative Biomaterials》2014年第1期37-47,共11页Ying Wang Shenglian Yao Qingyuan Meng Xiaolong Yu Xiumei Wang Fuzhai Cui 
This work was funded by National Basic Research Program of China(973 Program,No.2011CB606205);National Natural Science Foundation(No.81070977,No.81271388,No.81200931).
To declare the mechanisms of neural stem cells(NSCs)in response to material surface chemistry,NSCs were exposed to the self-assemble monolayers of alkanethiolates on gold surfaces terminated with amine(NH2),hydroxyl(O...
关键词：neural stem cell chemical group biomaterial gene expression RECEPTOR signaling pathway 
Advances in the surface modification techniques of bone-related implants for last 10 years被引量：14
《Regenerative Biomaterials》2014年第1期67-79,共13页Zhi-Ye Qiu Cen Chen Xiu-Mei Wang In-Seop Lee 
This work was partly supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,Korea(2012R1A1A2040717);the National Basic Research Program of China funded by the Ministry of Science and Technology(MOST)of China(2011CB606205);the National Science and Technology Supporting Program of China funded by the MOST of China(2012BAI17B02);the National Natural Science Fund funded by the National Natural Science Foundation of China(21371106).
At the time of implanting bone-related implants into human body,a variety of biological responses to the material surface occur with respect to surface chemistry and physical state.The commonly used biomaterials(e.g.t...
关键词：surface modification physicochemical coating radiation grafting plasma surface engineering ion beam processing surface patterning bone-related materials 
Degradable PRGD/PDLLA/β-TCP/NGF composites promote differentiation and regulate gene expression in rat pheochromocytoma cells被引量：1
《Chinese Science Bulletin》2013年第24期2979-2983,共5页QIU Tong YU Chang YAN QiongJiao LI ShiPu 
supported by the National Basic Research Program of China (2011CB606205)
In this study, we synthesized degradable PRGD/PDLLA/β-TCP/NGF composites to facilitate neuronal repair. To this end, we (1) examined the release of nerve growth factor (NGF) from the composites, (2) evaluated the dif...
关键词：细胞分化 复合材料 PDLLA 基因表达 合成降解 嗜铬细胞瘤 神经生长因子 神经元损伤 
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