国家自然科学基金(31170711)

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Kindlin-2通过mTOR和Hippo信号通路调节小鼠子宫内膜发育被引量：2
《北京大学学报（医学版）》2022年第5期846-852,共7页张京 宋佳桂 王振斌 龚玉清 王天卓 周津羽 战军 张宏权 
国家自然科学基金(81730071、82172972、31170711、81670626、81902840);北京大学双一流建设经费(PKU2021LCXQ023、BMU2022XKQ004)。
目的:探讨Kindlin-2对小鼠子宫发育及雌鼠生育能力的影响及其作用机制。方法:利用Cdh16-Cre工具鼠和Kindlin-2^(flox/flox)小鼠构建在子宫内膜中特异性敲除Kindlin-2的小鼠模型,观察敲除Kindlin-2对雌鼠子宫内膜发育和生殖力的影响。在...
关键词：Kindlin-2 小鼠 特异性敲除 子宫内膜 MTOR信号通路 Hippo信号通路 
LATS1 K751 acetylation blocks activation of Hippo signalling and switches LATS1 from a tumor suppressor to an oncoprotein被引量：2
《Science China(Life Sciences)》2022年第1期129-141,共13页Siyuan Yang Weizhi Xu Cheng Liu Jiaqi Jin Xueying Li Yuhan Jiang Lei Zhang Xianbin Meng Jun Zhan Hongquan Zhang 
supported by the National Natural Science Foundation of China(81730071,81972616,81230051,81472734,31170711 and 81773199);the Ministry of Science and Technology of China(2016YFC1302103 and 2015CB553906);Beijing Natural Science Foundation(7120002 and 7171005);Peking University(BMU2018JC004,BMU20120314 and BMU20130364)。
Large tumor suppressor 1(LATS1)is the key kinase controlling activation of Hippo signalling pathway.Post-translational modifications of LATS1 modulate its kinase activity.However,detailed mechanism underlying LATS1 st...
关键词：LATS1 acetylation LATS1 activation and inhibition Hippo signalling pathway lung adenocarcinoma 
细胞分裂周期相关蛋白7通过增强细胞增殖和干性促进人乳腺癌进程被引量：2
《解剖学报》2020年第6期888-896,共9页杨得草 刘程 马集 王梦远 战军 张宏权 
国家自然科学基金(81230051,81472734,31170711,81321003,81773199,30830048);科技部专项基金(2016YFC1302103,2015CB553906);北京市自然科学基金(7120002)。
目的探讨细胞分裂周期相关蛋白7(CDCA7)在人类乳腺癌中的相关功能及潜在的作用机制。方法通过癌症和肿瘤基因图谱(TCGA)数据库分析检索出不同乳腺癌亚型差异表达基因,找到在基底型乳腺癌中高表达基因,在这些基因中找到CDCA7,通过临床患...
关键词：细胞分裂周期相关蛋白7 Basal-like/luminal乳腺癌 干细胞 Β-连环蛋白 流式细胞术 人 
Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal adenocarcinoma被引量：2
《Frontiers of Medicine》2020年第1期91-100,共10页Xiaoran Sun Jiagui Song Jing Zhang Jun Zhan Weigang Fang Hongquan Zhang 
supported by grants from the Ministry of Science and Technology of China(Nos.2016YFC1302103 and 2015CB553906);the National Natural Science Foundation of China(Nos.81730071,81230051,81472734,and 31170711);the Beijing Natural Science Foundation(Nos.7120002 and 7171005);This work was also supported by a grant from the National Natural Science Foundation of China(No.81773199)to Jun Zhan.
Pancreatic ductal adenocarcinoma(PDAC)is the ninth most common human malignancy and the sixth leading cause of cancer-related death in China.AcK27-HOXB9 is a newly identified HOXB9 post-transcriptional modification th...
关键词：HOXB9 AcK27-HOXB9 PDAC 
C1orf106, an innate immunity activator, is amplified in breast cancer and is required for basal-like/luminal progenitor fate decision被引量：2
《Science China(Life Sciences)》2019年第9期1229-1242,共14页Ji Ma Cheng Liu Decao Yang Jiagui Song Jing Zhang Tianzhuo Wang Mengyuan Wang Weizhi Xu Xueying Li Shigang Ding Jun Zhan Hongquan Zhang 
supported by the Ministry of Science and Technology of China (2016YFC1302103 and 2015CB553906);the National Natural Science Foundation of China (81230051, 81472734,31170711, 81321003, and 30830048);the Beijing Natural Science Foundation (7120002);the 111 Project of the Ministry of Education, Peking University (BMU2018JC004, BMU20120314, and BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau to H.Z;a grant from the National Natural Science Foundation of China (81773199) to J.Z
Basal-like breast cancer with a luminal progenitor gene expression profile is an aggressive subtype of breast cancer with a poorer prognosis compared with other subtypes.However,genes that specifically promote basal-l...
关键词：C1orf106 BASAL-LIKE LUMINAL PROGENITOR breast cancer ELF5 GATA3 
G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma被引量：2
《Frontiers of Medicine》2019年第4期482-491,共10页Wenjing Wang Shigang Ding Hejun Zhang Jun Li Jun Zhan Hongquan Zhang 
This study was supported by grants from the Ministry of Science and Technology ofChina (Nos. 2016YFC1302103,2015CB553906, and 2013CB910501);the National Natural Science Foundation of China (Nos. 81230051, 81472734, 31170711, 81321003, and 30830048);the Beijing Natural Science Foundation (No. 7120002);the 111 Project of the Ministry of Education, Peking University (Nos. BMU20120314 and BMU20130364);and the Leading Academic Discipline Project of Beijing Education Bureau to Hongquan Zhang.
LGR6 is a member of the G protein-coupled receptor family that plays a tumor-suppressive role in colon cancer. However, the relationship between LGR6 expression in patients and clinicopathological factors remains uncl...
关键词：LGR6 COLON ADENOCARCINOMA IMMUNOHISTOCHEMISTRY PROGNOSIS 
Integrin-interacting protein Kindlin-2 induces mammary tumors in transgenic mice被引量：6
《Science China(Life Sciences)》2019年第2期225-234,共10页Bing Li Xiaochun Chi Jiagui Song Yan Tang Juan Du Xiaokun He Xiaoran Sun Zhenwu Bi Yunling Wang Jun Zhan Hongquan Zhang 
supported by grants from the Ministry of Science and Technology of China (2016YFC1302103, 2015CB553906, and 2013CB910501);the National Natural Science Foundation of China (81730071, 81230051, 81472734, and 31170711);the Beijing Natural Science Foundation (7120002 and 7171005);the 111 Project of the Ministry of Education, grants from Peking University (BMU20120314 and BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau to H.Z.;supported by a grant from the National Natural Science Foundation of China (81773199) to J.Z
Kindlin-2, an integrin-interacting protein, regulates breast cancer progression. However, currently, no animal model to study the role of Kindlin-2 in the carcinogenesis of mammary gland is available. We established a...
关键词：Kindlin-2 breast cancer MOUSE MAMMARY GLAND growth MAMMARY TUMORIGENESIS TRANSGENIC MOUSE 
Kindlin-1和Kindlin-2的差异表达与食管癌的进程及流行病学特点的相关性被引量：3
《中国科学：生命科学》2018年第1期93-101,共9页王鹏 战军 宋佳桂 王允玲 方伟岗 刘芝华 张宏权 
中国科技部基金(批准号：2016YFC1302103,2015CB553906,2013CB910501); 国家自然科学基金(批准号：81230051,81472734,31170711,81321003,81301802,30830048); 北京自然科学基金(批准号：7120002); 北京大学教育部111项目(批准号：BMU20120314,BMU20130364); 北京教育局领导学科项目资助
食管癌是中国最致命的恶性肿瘤之一,但其病因和危险因素的分子机制仍不清楚.整合素相互作用蛋白Kindlin-1和Kindlin-2可以激活跨膜受体整合素,调节肿瘤细胞的生长、侵袭和转移.本研究首次发现,在中国食管癌患者中,Kindlin-1和Kindlin-2...
关键词：Kindlin-1 Kindlin-2 食管癌 流行病学 
Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology被引量：1
《Science China(Life Sciences)》2017年第11期1214-1222,共9页peng wang jun zhan jiagui song yunling wang weigang fang zhihua liu hongquan zhang 
supported by the Ministry of Science and Technology of China (2016YFC1302103, 2015CB553906. 2013CB910501);the National Natural Science Foundation of China (81230051, 81472734, 31170711, 81321003, 81301802, 30830048);Beijing Natural Science Foundation (7120002);the 111 Project of the Ministry of Education, Peking University (BMU20120314, BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau to Hongquan Zhang
Esophageal cancer （EC） is one of the most lethal malignancies in China, but the etiology and risk factors remain unclear. The integrin-interacting proteins Kindlin-1 and Kindlin-2 are focal adhesion molecules that a...
关键词：Kindlin-l Kindlin-2 esophageal cancer EPIDEMIOLOGY 
Depletion of Kindlin-2 induces cardiac dysfunction in mice被引量：1
《Science China(Life Sciences)》2016年第11期1123-1130,共8页Lihua Qi Yu Yu Xiaochun Chi Danyu Lu Yao Song Youyi Zhang Hongquan Zhang 
supported by the Ministry of Science and Technology of China(2015CB553906,2013CB910501);the National Natural Science Foundation of China(81500180,81230051,81472734,31170711,81321003,30830048);Beijing Natural Science Foundation(7120002);the 111 Project of the Ministry of Education,Peking University(BMU20120314,BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau to Hongquan Zhang
Kindlin-2, a member of the Kindlin family focal adhesion proteins, plays an important role in cardiac development. It is known that defects in the Z-disc proteins lead to hypertrophic cardiomyopathy(HCM) or dilated ca...
关键词：Kindlin-2 depletion myocardial hypertrophy cardiac dysfunction MOUSE 
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