《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》

作品数：2596被引量：10109H指数：27
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《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》
主办单位：Zhejiang University
最新期次：2025年3期更多>>
发文主题：APOPTOSISGENEPATIENTSSCIENCEMETA-ANALYSIS更多>>
发文领域：医药卫生农业科学生物学环境科学与工程更多>>
发文作者：张俊丽刘妮孟以蓉黄正昌朱宇同更多>>
发文机构：金华市中心医院浙江省人民医院松阳县中医院丽水市中医院更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家科技支撑计划更多>>
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Immune checkpoint blockade for cancer therapy: current progress and perspectives
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第3期203-226,共24页Hongying YE Wejie LIAO Jiongli PAN Yin SHI Qingqing WANG 
supported by the National Key Research and Development Program of China(No.2022YFE0102100);the National Natural Science Foundation of China(Nos.U22A20307 and 81930041)。
Dysfunction of anti-tumor immune responses is crucial for cancer progression. Immune checkpoint blockade(ICB), which can potentiate T cell responses, is an effective strategy for the normalization of host anti-tumor i...
关键词：Immune checkpoint blockade Cancer immunotherapy Tumor immune evasion Immune normalization 
Autophagy in skeletal muscle dysfunction of chronic obstructive pulmonary disease: implications, mechanisms, and perspectives
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第3期227-239,共13页Xiaoyu HAN Peijun LI Meiling JIANG Yuanyuan CAO Yingqi WANG Linhong JIANG Xiaodan LIU Weibing WU 
supported by the National Natural Science Foundation of China(No.82172551);the Health Discipline Leader Project of Shanghai Municipal Health Commission(No.2022XD044),China.
Skeletal muscle dysfunction is a common extrapulmonary comorbidity of chronic obstructive pulmonary disease(COPD) and is associated with decreased quality-of-life and survival in patients. The autophagy lysosome pathw...
关键词：AUTOPHAGY Skeletal muscle dysfunction Chronic obstructive pulmonary disease MITOCHONDRIA Muscle satellitecell 
OX40 ligand promotes follicular helper T cell differentiation and development in mice with immune thrombocytopenia
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第3期240-253,共14页Ziyin YANG Lei HAI Xiaoyu CHEN Siwen WU Yan LV Dawei CUI Jue XIE 
supported by the National Natural Science Foundation of China(Nos.82172335,81971994,91846103,and 81871709);the Zhejiang Provincial Key Research and Development Program(No.2020C03032),China.
Immune thrombocytopenia(ITP)is a hemorrhagic autoimmune disease characterized by antibody-mediated platelet injury.ITP has complicated immunopathological mechanisms that need further elucidation.It is well known that ...
关键词：OX40 OX40 ligand(OX40L) Immune thrombocytopenia Follicular helper T(Tfh)cell B cell 
SP7 transcription factor ameliorates bone defect healing in low-density lipoprotein receptor-related protein 5(LRP5)-dependent osteoporosis mice
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第3期254-268,共15页Yue XI Qifeng JIANG Wei DAI Chaozhen CHEN Yang WANG Xiaoyan MIAO Kaichen LAI Zhiwei JIANG Guoli YANG Ying WANG 
Loss-of-function variants of low-density lipoprotein receptor-related protein 5(LRP5)can lead to reduced bone formation,culminating in diminished bone mass.Our previous study reported transcription factor osterix(SP7)...
关键词：Gene therapy Low-density lipoprotein receptor-related protein 5(LRP5) Transcription factor osterix(SP7) OSTEOPOROSIS Defect healing 
High-dose estrogen impairs demethylation of H3K27me3 by decreasing Kdm6b expression during ovarian hyperstimulation in mice
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第3期269-285,共17页Quanmin KANG Fang LE Xiayuan XU Lifang CHEN Shi ZHENG Lijun LOU Nan JIANG Ruimin ZHAO Yuanyuan ZHOU Juan SHEN Minhao HU Ning WANG Qiongxiao HUANG Fan JIN 
supported by the National Key Research and Development Program of China(No.2018YFC1004900);the National Natural Science Foundation of China(No.82101799);the Health Science and Technology Foundation of Zhejiang Province of China(No.2022KY186).
Given that ovarian stimulation is vital for assisted reproductive technology(ART)and results in elevated serum estrogen levels,exploring the impact of elevated estrogen exposure on oocytes and embryos is necessary.We ...
关键词：Ovarian stimulation Histone methylation Assisted reproductive technology(ART) 
Promising protective treatment potential of endophytic bacterium Rhizobium aegyptiacum for ulcerative colitis in rats
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第3期286-301,共16页Engy ELEKHNAWY Duaa ELIWA Sebaey MAHGOUB Sameh MAGDELDIN Ehssan MOGLAD Sarah IBRAHIM Asmaa Ramadan AZZAM Rehab AHMED Walaa A.NEGM 
funding provided by The Science,Technology&Innovation Funding Authority(STDF)in cooperation with The Egyptian Knowledge Bank(EKB).
Ulcerative colitis(UC)is an inflammatory condition of the intestine,resulting from an increase in oxidative stress and pro-inflammatory mediators.In this study,the extract of endophytic bacterium Rhizobium aegyptiacum...
关键词：Inflammatory bowel syndrome Liquid chromatography-tandem mass spectrometry(LC-MS/MS) Scanning electron microscopy(SEM) HISTOLOGY Immunohistochemistry Reverse transcription-quantitative polymerase chain reaction(RT-qPCR) 
Erratum to: Advantages of contrast-enhanced ultrasound in the localization and diagnostics of sentinel lymph nodes in breast cancer
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第3期302-302,共1页Qiuhui YANG Yeqin FU jiaxuan WANG Hongjan YANGI Xiping ZHANG 
the funding information for the Zhejiang Provincial Natural Science Foundation of China(No.LBY21H160001)was wrong;The correct funding should be the Zhejiang Health Science and Technology Project(No.2022KY682),China.
Roles of lncRNA in the crosstalk between osteogenesis and angiogenesis in the bone microenvironment
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第2期107-123,共17页Shihua ZHANG Jianmin GUO Yuting HE Zhi’ang SU Yao FENG Lan ZHANG Jun ZOU Xiquan WENG Yu YUAN 
supported by the National Natural Science Foundation of China(No.81901430);the Guangdong Basic and Applied Basic Research Foundation(No.2022A1515010379);the Science and Technology Projects in Guangzhou(No.2023A04J0555);the Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion(No.2021B1212040014),China.
Bone is a highly calcified and vascularized tissue.The vascular system plays a vital role in supporting bone growth and repair,such as the provision of nutrients,growth factors,and metabolic waste transfer.Moreover,th...
关键词：Long noncoding RNA(lncRNA) OSTEOGENESIS Bone angiogenesis OSTEOPOROSIS Bone microenvironment 
Advancements in molecular imaging probes for precision diagnosis and treatment of prostate cancer
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第2期124-144,共21页Jiajie FANG Ahmad ALHASKAWI Yanzhao DONG Cheng CHENG Zhijie XU Junjie TIAN Sahar Ahmed ABDALBARY Hui LU 
supported by the Medical Health Science and Technology Project of Zhejiang Provincial Health Com-mission(No.2022RC146);the Zhejiang Provincial Natural Science Foundation of China(No.LQ22H050003).
Prostate cancer is the second most common cancer in men,accounting for 14.1%of new cancer cases in 2020.The aggressiveness of prostate cancer is highly variable,depending on its grade and stage at the time of diagnosi...
关键词：Molecular imaging Prostate cancer Nuclear medicine Prostate-specific membrane antigen(PSMA) NANOPARTICLE 
Efficacy of adjunctive systemic or local antibiotic therapy in peri-implantitis:a systematic review and meta-analysis of randomized controlled clinical trials
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第2期145-157,共13页Yifan LU Siqi BAO Hongke LUO Qianming CHEN Misi SI 
supported by the Fundamental Research Funds for the Central Universities(No.2023QZJH59/226-2023-00155);the National Natural Science Foundation of China(Nos.82370990 and 82201051);the Medical Health Science and Technology Project of Zhejiang Provincial Health Commis-sion(No.WKJ-ZJ-2335);the Innovative Talent of Zhejiang Provincial Health Commission,the Zhejiang“Xinmiao”Tal-ents Program(No.2023R401211),China.
This systematic review and meta-analysis considered the results of randomized controlled clinical trials(RCTs)to evaluate the efficacy of systemic or local antibiotic therapy in peri-implantitis.Two independent author...
关键词：PERI-IMPLANTITIS Dental implant Oral medicine MICROBIOLOGY Disease management META-ANALYSIS 
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