National Natural Science Foundation of China(82271241 and 82001172 to XLZ,81801112 to MXX);Guangdong Basic and Applied Basic Research Foundation(2022A1515012389 to MXX,2022A1515012543 to RCL);Young Talent Support Project of Guangzhou Association for Science and Technology(QT20220101169 to XLZ);Excellent Young Talents Project of Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences(KY012021188 to XLZ);Science and Technology Projects in Guangzhou(202201010792 to RCL)。
Background Tactile and mechanical pain are crucial to our interaction with the environment,yet the underpinning molecular mechanism is still elusive.Endophilin A2(EndoA2)is an evolutionarily conserved protein that is ...
National Key Research and Development Program of China(2023YFC2505900);National Natural Science Foundation of China(92269204,82171755,92369106,82171749,82171811,82073184);Military Outstanding Youth Program(2020QN06119,01-SWK JYCJJ07,23SWAQ53);Program of Leading Talents in Shanghai,and Shanghai Shuguang Program(20SG39)。
Background Liver ischemia/reperfusion(I/R)injury is usually caused by hepatic inflow occlusion during liver surgery,and is frequently observed during war wounds and trauma.Hepatocyte ferroptosis plays a critical role ...
This work was NIH(R01NS092466),NSFC(U2004201);Central Plains Thousand People Plan of Henan Province(204200510013);Henan Overseas Expertise Introduction Center for Discipline Innovation(CXJD2021002);Key Special Project of Zhengzhou University Disciplinary Construction(XKZDJC202001)。
Background:The channel-forming protein Pannexin1(Panx1)has been implicated in both human studies and animal models of chronic pain,but the underlying mechanisms remain incompletely understood.Methods:Wild-type(WT,n=24...
Chinese Scholarship Council(202206240086);National Natural Science Foundation of China(81974099,82170785,81974098,82170784);National Key Research and Development Program of China(2021YFC2009303);programs from Science and Technology Department of Sichuan Province(2021YFH0172);Young Investigator Award of Sichuan University 2017(2017SCU04A17);Technology Innovation Research and Development Project of Chengdu Science and Technology Bureau(2019-YF05-00296-SN);Sichuan University-Panzhihua science and technology cooperation special fund(2020CDPZH-4).
In recent years,advancements in single-cell and spatial transcriptomics,which are highly regarded developments in the current era,particularly the emerging integration of single-cell and spatiotemporal transcriptomics...
Chronic,non-healing wounds represent a significant challenge for healthcare systems worldwide,often requiring significant human and financial resources.Chronic wounds arise from the complex interplay of underlying com...
USA National Institutes of Health Grant(R01-HL-139547,to JF);USA VA Grants(1I01BX004838 and IK6BX004211,to JF);National Natural Science Foundation of China(82002087,to TG);Shenzhen Science and Technology Program(JCYJ20210324134602008,to TG)。
Sepsis,a severe systemic inflammatory response to infection,remains a leading cause of morbidity and mortality worldwide.Exosomes,as mediators of intercellular communication,play a pivotal role in the pathogenesis of ...
National Key Research and Development Program of China(2022YFA1103202);National Natural Science Foundation of China(82272507,32270887,and 32200654);Natural Science Foundation of Chongqing(CSTB2023NSCQ-ZDJO008);Postdoctoral Innovative Talent Support Program(BX20220397);Independent Research Project of State Key Laboratory of Trauma and Chemical Poisoning(SFLKF202201);Project for Enhancing Innovation of Army Medical University(2023X1839);Talent Innovation Training Program at the Army Medical Center(ZXZYTSYS09);General Hospital of Western Theater Command Research Project(2021-XZYG-B10);University Grants Committee,Research Grants Council of Hong Kong,China(14113723,N_CUHK472/22,C7030-18G,T13-402/17-N,and AoE/M-402/20)。
Orthopedic conditions have emerged as global health concerns,impacting approximately 1.7 billion individuals worldwide.However,the limited understanding of the underlying pathological processes at the cellular and mol...
Department of Defense(W81XWH-17-1-0447 and W81XWH1910548 to AKS);Texas A&M University School of Medicine。
Over one-third of 700,000 military personnel who served in the first Gulf War(GW)suffer from an assortment of symptoms,including cognitive and memory problems,musculoskeletal pain,gastrointestinal discomfort,fatigue,a...
supported by the Military Medical Science and Technology Youth Cultivation Program of the Chinese PLA(17QNP023);the Key Projects of Medical Service Scientific Research of the Navy Medical Center(20M2302);the Military Logistics National Military Standard General Project of Chinese PLA(BHJ22B002).
Dear Editor,In recent years,there has been a significant upward trend in the detection rate of thyroid diseases among military flight personnel[1].Thyroid diseases not only pose a serious threat to the health of fligh...