funded by grants from the British Journal of Anaesthesia,London,UK and the European Society of Anesthesiology and Intensive Care,Brussels,Belgium.
Coronavirus disease 2019(COVID-19)has caused>760 million SARS-CoV-2 infections and 6.9 million deaths globally as reported by the World Health Organization(WHO).The virus is predominately a respiratory virus,but it ha...
Shanghai Directed Projects of Biopharmaceutical Field(22DX1900600)Shanghai Research Center for Burn and Wound Repair(2023ZZ02013);Shanghai Municipal Key Clinical Specialty of China(shslczdzk02302).
Burns are a main cause of accidental injuries among children in China.Because of the unique wound repair capacity and demand for growth in pediatric patients,the management of pediatric deep partial-thickness burn wou...
funded by the National Natural Science Foundation of China(No.82172202);the Innovative Leading Talents Project of Chongqing,China(No.cstc2022ycjh-bgzxm0148).
Background:The gut microbiota is a complex ecosystem that plays a critical role in human health and disease.However,the relationship between gut microbiota and intestinal damage caused by burns is not well understood....
Brain injuries are common complications in patients with thermal burns and are associated with unpleasant outcomes.In clinical settings,it was once believed that brain injuries were not major pathological processes af...
supported by the National Natural Science Foundation of China(82104495 and 82174161);Shenzhen Fundamental Research Program(No.SGDX20210823103804030);Science and Technology Development Fund,Macao SAR(No.0025/2022/A1);University of Macao grants(No.MYRG2019-00129-ICMS);Macao Youth Scholars Program(AM2021023);Guangdong Basic and Applied Basic Research Foundation(2022A1515010395 and 2021A1515012573);Science and Technology Foundation of Guangzhou City(202102010257);State Key Laboratory of Dampness Syndrome of Chinese Medicine Research Foundation(SZ2021ZZ21 and SZ2022QN02);Scientific Research Projects of Guangdong Bureau of Traditional Chinese Medicine(Nos.20212088);TCM Research Fund of Guangdong Provincial Hospital of Chinese Medicine(YN2020MS13);The 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund(Guangdong-Hong Kong-Macao Joint Lab,No.2020B1212030006 and MY2022KF05).
Autophagy is a highly conserved bulk degradation mechanism that degrades damaged organelles,aged proteins and intracellular contents to maintain the homeostasis of the intracellular microenvironment.Activation of auto...
supported by the Key Program of the National Natural Science Foundation of China(82030056);the Intramural Research Project Grants(2021-JCJQ-ZD-077-11,AWS17J007 and 2018-JCJQ-ZQ-001);Postdoctoral Innovative Talent Support Program in Chongqing(CQBX2021010).
Background:Radiation ulcers are a common and severe injury after uncontrolled exposure to ionizing radiation.The most important feature of radiation ulcers is progressive ulceration,which results in the expansion of r...
supported by the National Natural Science Foundation of China(52003048);China Postdoctoral Science Foundation(2021 T140110).
Background:Wound healing is a process that requires angiogenesis and antibacterial activities and it remains a challenge for both experimental and clinical research worldwide.Zn2+has been reported to be widely involve...
supported by the National Natural Science Foundation of China,No.82072217,81772135 and U21A20370;the Jiangsu Natural Science Foundation,No.BE2017695 and BK20201178.
Background:Early detection,timely diagnosis and rapid response are essential for case management and precautions of burn-associated sepsis.However,studies on indicators for early warning and intervention have rarely b...
supported by National Health and Medical Research Council(NHMRC)fund(APP1101879);National Science Foundation of China(82172217)and ANZAC Research Institute near miss funding.
Background:Excessive scarring and fibrosis are the most severe and common complications of burn injury.Prolonged exposure to high levels of glucocorticoids detrimentally impacts on skin,leading to skin thinning and im...
supported by the National Natural Science Foundation of China(82173446);the Youth Training Program of Military Medical Science and Technology(21QNPY003).
Background:Burn wound healing is a complex process and the role of Wnt ligands varies in this process.Whether and how Wnt4 functions in burn wound healing is not well understood.In this study,we aim to reveal the effe...