云南高校图书馆联盟文献共享服务平台- Advances in Precision Medicine

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Genomics Vault: A framework for precision medicine data management: 《Advances in Precision Medicine》2017年第2期1-8,共8页Bhupinder Bhullar Guy Gross Hakan Akozek; A mixture of fumaric acid esters (FAEs) is approved for the oral therapy of psoriasis. However, for a long time the active ingredient of this mixture was unknown. We reviewed the in vitro data available for the differ...; 关键词：DIMETHYLFUMARATE (DMF) monoethylfumarate (MEF) monomethylfumarate (MMF) fumaric acid esters(FAEs) PSORIASIS

The SMART healthcare solution: 《Advances in Precision Medicine》2017年第1期20-22,共3页Basil H. Chaballout Ryan J. Shaw Karin Reuter-Rice; Substitutable Medical Apps Reusable Technologies (SMART■) on Fast Healthcare Interoperability Resources (FHIR) is an open, standards platform that allows third parties to build health applications that interact with ...; 关键词：electronic HEALTH RECORD (EHR) PRECISION MEDICINE data VISUALIZATION

Validation of novel multiplex technologies: 《Advances in Precision Medicine》2017年第1期1-9,共9页Levent Akyuz Andreas Wilhelm Florian Butke Park Su-Jin Anja Kuckuck Hans-Dieter Volk Gerald Grutz; Cytokine and chemokine levels in body fluid provide information of altered conditions in patients. The parallel analysis of multiple factors, such as cytokines, from small sample sizes is an interesting approach for t...; 关键词：BIOMARKER multiplex CYTOKINE CHEMOKINE SOLUBLE FACTORS

Identifying the active pharmaceutical ingredient from a mixture of fumaric acid esters for the treatment of psoriasis: Hints from in vitro investigations: 《Advances in Precision Medicine》2017年第1期10-19,共10页Lilla Landeck Adriana Amasuno Ignasi Pau-Charles Khusru Asadullah; A mixture of fumaric acid esters (FAEs) is approved for the oral therapy of psoriasis. However, for a long time the active ingredient of this mixture was unknown. We reviewed the in vitro data available for the differ...; 关键词：DIMETHYLFUMARATE (DMF) monoethylfumarate (MEF) monomethylfumarate (MMF) fumaric acid esters(FAEs) PSORIASIS

Precision medicine: do not neglect the hurdles: 《Advances in Precision Medicine》2016年第2期1-2,共2页Lilla Landeck Patricia Carrigan Khusru Asadullah; Tremendous expectations have been connected with precision medicine in the past years. Beside the advantages that this type of therapy offers we should be aware of its challenges too. In this issue we will highlight o...; 关键词：PRECISION MEDICINE DO not NEGLECT the hurdles Tremendous expectations

Reproducibility of preclinical data: one man's poison is another man's meat: 《Advances in Precision Medicine》2016年第2期3-12,共10页Anton Bespalov Christoph H. Emmerich Bjorn Gerlach Martin C. Michel; Limited reproducibility of preclinical data is increasingly discussed in the literature. Failure of drug development programs due to lack of clinical efficacy is also of growing concern. The two phenomena may share an...; 关键词：animal models data REPRODUCIBILITY heterogeneity precision medicine TRANSLATIONAL research

Personalized medicine: consequences for drug research and therapy: 《Advances in Precision Medicine》2016年第2期13-21,共9页Thorsten Ruppert Sabine Sydow Günter Stock; In drug research, a serious transformation has taken place. With increasing knowledge gained from molecular medicine, it became possible to refine and develop new therapies based on the molecular mechanisms of disease...; 关键词：PERSONALIZED medicine STRATIFICATION of PATIENT GROUPS tandems of THERAPEUTIC agents and diagnostic tests PATIENT care cost efficiency

The role of open innovation in biomarker discovery: 《Advances in Precision Medicine》2016年第2期22-25,共4页Lilla Landeck Monika Lessl Andreas Busch Matthias Gottwald Khusru Asadullah; Precision medicine aims to treat diseases with special consideration for the individual biological variability. Novel biomarkers (BM) are needed to predict therapeutic responses and to allow for the selection of suita...; 关键词：OPEN INNOVATION BIOMARKER PRECISION MEDICINE crowd SOURCING

Success factors in drug discovery and development: 《Advances in Precision Medicine》2016年第2期26-30,共5页Bjorn Wallmark; The article aimed to give a personal perspective on drug discovery and development. The author has worked both in Big Pharma as a scientist and manager and more recently also in start-up biotech companies. Drug compan...; 关键词：pharmaceutical industry productivity factors

The research data reproducibility problem solicits a 21^st century solution: 《Advances in Precision Medicine》2016年第2期31-34,共4页Bhupinder Bhullar; Reproducibility is a hallmark of scientific efforts. Estimates indicate that lack of reproducibility of data ranges from 50% to 90% among published research reports. The inability to reproduce major findings of publis...; 关键词：DATA REPRODUCIBILITY SCIENTIFIC method

《Advances in Precision Medicine》