《Precision Medicine Research》

作品数：92被引量：15H指数：2
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《Precision Medicine Research》
主办单位：TMR Publishing Group
最新期次：2023年3期更多>>
发文主题：TREATMENTMECHANISMBASED_ONTUMORBIOINFORMATICS更多>>
发文领域：医药卫生自动化与计算机技术理学经济管理更多>>
发文基金：国家自然科学基金中国博士后科学基金天津市自然科学基金广西壮族自治区自然科学基金更多>>
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Pan-cancer analysis of positive regulatory domain-containing 16 in human tumors
《Precision Medicine Research》2023年第3期1-10,共10页Shi-Yi Zhang Ting-Ting Yang Xiang-Xing He Fang Yang Lin Zhang 
This study was financially supported by the Young Teachers Support Program of Hubei University of Chinese Medicine(2021ZZX025);Hubei Province College Students’innovation and entrepreneurship training program(S202210507018).
Background:Positive regulatory domain-containing 16(PRDM16)plays a key role in brown adipose transcription,but its function in cancer is unclear.Our research to investigate the potential roles of PRDM16 across multipl...
关键词：positive regulatory domain-containing 16 pan-cancer prognosis immune infiltration 
Structure-based multi-ligand molecular modeling to predict the synergistic effects of limonin and obacunone from Simiao pill against nitric oxide synthase 3 associated with hyperuricemia
《Precision Medicine Research》2023年第3期11-15,共5页Qing-Hong Chen Xiao-Mei Chen Xiao-Hu Chen Yan-Ting You Shu-Xuan Yang Chuang-Hai Wu Mei-Lin Chen Ming-Di Li Akari Komori Yan-Yan Liu Andrew Hung Xiao-Shan Zhao Hong Li 
This work was funded by the Key Project of National Natural Science Foundation of China[grant number 81830117];Joint Funds of National Natural Science Foundation of China[grant number U22A20365];National Natural Science Foundation of China[grant numbers 8220140209,82274499];Guangdong Basic and Applied Basic Research Foundation[grant number 2021A1515110082];China Postdoctoral Science Foundation[grant number 2022M711534];Science&Technical Plan of Guangzhou,Guangdong,China[grant number 201903010069].
Hyperuricemia(HUA)mainly occurs because of purine metabolism disorders.We recently proposed that limonin from Simiao pill may have therapeutic effects on nitric oxide synthase 3(NOS3)that is related to HUA.Concurrentl...
关键词：HYPERURICEMIA synergistic mechanism Chinese herbal medicine complementary and alternative medicine molecular docking molecular dynamics simulations in silico analysis 
Investigating the effect of rubiadin cytotoxicity and expression of BAX and BCL2 genes on HepG2 liver cancer cell line
《Precision Medicine Research》2023年第3期16-19,共4页Sanaz Pashapour Abbas Zabihi Yeganeh Hamidi Masoumeh Heshmati 
Background:Rubiadin is a type of anthraquinone compound that can be found in Rubiaceae plants,such as Ronas.Nonetheless,only limited research has been done to explore the potential anticancer properties of rubiadin on...
关键词：rubiadin VIABILITY AGO HEPG2 BAX BCL2 BAX/BCL2 
Suppressed effects of Phyllanthus urinaria L.ethyl acetate extract on hepatitis B virus both in vitro and in vivo被引量：2
《Precision Medicine Research》2023年第3期20-28,共9页Zhi-Ling Chen Rui Zhang 
This work was supported by Natural Science Foundation of Hainan Province(Grant No.821QN0998);Key R&D Plan of Hainan Province(Grant No.ZDYF2023SHFZ116);Postgraduate Innovation Project of Hainan Province(Grant No.Qhyb2022-131,Qhys2022-281);supported by Hainan Province Clinical Medical Center.
Background:Phyllanthus urinaria L.(P.urinaria)extract(PUE)has been used to inhibit hepatitis B virus(HBV).However,the underlying mechanism remains unclear.To investigate which PUE fractions and main components lead to...
关键词：hepatitis B virus Phyllanthus urinaria L. FRACTIONS reactive oxygen species formation metabolomics 
Effects of curcumin on uterine leiomyoma in a rat model by inhibiting β-catenin/Wnt signaling pathway
《Precision Medicine Research》2023年第2期1-7,共7页Wen-Xian Li Jia-Li Bai Li Fu Ya-Jing Zhu Ge Fan Bing Yang Cheng-Liang Yin 
Background:Women with uterine leiomyomas may suffer severe symptoms.To avoid risks of side effects,it is necessary to develop an optimal agent to shrink leiomyomas with fewer side effects and a lower recurrence rate.C...
关键词：LEIOMYOMA CURCUMIN Wnt signaling pathway ESTROGENS PROGESTERONE 
Novel coumarone-derived(S,E)-4-(4-fluorobenzylidene)-3-phenylchroman-3-ol inhibits muscle-invasive bladder cancer cells by repressing the S and G2 cell cycle phases
《Precision Medicine Research》2023年第2期8-15,共8页Xin-Yi Han A-Dan Li Fa-Ying Zhou Chao Li Guo-Du Liu Yong Xia 
supported by National Nature Science Foundation of China(82172978);Taishan Scholars Program of Shandong Province(Grant No.tsqn201909147);the Key Project at Central Government Level:the ability establishment of sustainable use for valuable Chinese medicine resources(2060302);the Student Innovation Training Program in Jining Medical University(cx2021116).
Background:This study aimed to select compounds with unique inhibitory effects on muscle-invasive bladder cancer(MIBC)from coumarone derivatives with similar parent nuclear structures and to reveal their tumor-suppres...
关键词：muscle-invasive bladder cancer cell proliferation cell cycle DNA replication coumarone derivate 
Elucidating the molecular targets of Curcuma longa for breast cancer treatment using network pharmacology,molecular docking and molecular dynamics simulation
《Precision Medicine Research》2023年第2期16-31,共16页Christopher Terseer Tarkaa Damilare Adebayo Oyaniyi Ridwan Abiodun Salaam Rachael Pius Ebuh Olusola Abayomi Akangbe Sayo Ebenezer Oladokun Rodiat Omotola Sowemimo Oluwaponmile Florence Ajayi 
Background:To elucidate the molecular mechanisms of Curcuma longa(C.longa)in breast cancer treatment.Methods:Phytocompounds of C.longa were obtained from Dr.Duke’s Phytochemical and Ethnobotanical Database.Potential ...
关键词：Curcuma longa network pharmacology breast cancer MECHANISM molecular docking molecular dynamics simulation 
To explore the mechanism of Naodesheng tablets in the treatment of atherosclerosis based on network pharmacology and bioinformatics
《Precision Medicine Research》2023年第2期32-42,共11页Peng-Yu Wang Jia-Hui Hu Shuo Zhang Zhuo-Ling Chu You-Zhi Zhang 
supported by a grant from Key Project of Education Commission of Hubei Province(D20202802).
Background:Naodesheng tablets(NDST)was widely used in clinical treatment as a drug for cardiovascular diseases,but the mechanism for treating atherosclerosis was unknown.On the basis of network pharmacology and bioinf...
关键词：Naodesheng tablets ATHEROSCLEROSIS network pharmacology BIOINFORMATICS molecular docking 
Mechanism of Cordyceps sinensis in atherosclerosis treatment based on network pharmacology and molecular docking analysis
《Precision Medicine Research》2023年第2期43-50,共8页Jin-Rong Lang Yue Hao Ping Li Zi-Yu Cui Qi-Qing Cheng Shi Wang 
supported by the Educational Commission of Hubei Province of China(D20222802).
Background:The present study intented to delve into the molecular mechanism of Cordyceps sinensis(C.sinensis)in treating atherosclerosis by combining network pharmacology and molecular docking analysis.Methods:We sear...
关键词：Cordyceps sinensis ATHEROSCLEROSIS network pharmacology molecular docking 
Advances on biological evaluation methods of programmed cell death protein-1/ligand-1 inhibitors
《Precision Medicine Research》2023年第2期51-55,共5页Qi Miao Wan-Heng Zhang 
Immuno-oncology represents a groundbreaking and well-established field within cancer treatment.Among the various immuno-oncology targets,the exploration of programmed cell death-1/ligand-1 for drug discovery has prove...
关键词：programmed cell death-1/ligand-1 inhibitors BIOASSAYS drug candidate evaluation 
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