supported by the National Natural Science Foundation of China under grant nos.62176231 and 82202984;the Zhejiang Key R&D Program of China under grant no.2023C03053。
Background:Proteins govern most biological functions essential for life,and achieving controllable protein editing has made great advances in probing natural systems,creating therapeutic conjugates,and generating nove...
supported by the National Natural Science Foundation of China(grant nos.82330107,72361127500,and 82204175).
Background:Early-onset type 2 diabetes(T2D)is an increasingly serious public health issue,particularly in China.This study aimed to analyze the characteristics of disease burden,secular trend,and attributable risk fac...
In the Research Article“Detection of patients at risk of multidrugresistant Enterobacteriaceae infection using graph neural networks:A retrospective study”,Table 2 was incorrectly duplicated[1].TTe correct Table 1 i...
supported by the Research and Development Fund of Peking University People’s Hospital(Missing Data in Electronic Health Records program[MINDER])(RDX2023-11);the National Natural Science Foundation of China(No.62102008 and No.81602939).
Background:Missing data in electronic health records(EHRs)presents signiffcant challenges in medical studies.Many methods have been proposed,but uncertainty exists regarding the current state of missing data addressin...
supported by the Duke/Duke-NUS Collaboration grant.
Background:Federated learning(FL)holds promise for safeguarding data privacy in healthcare collaborations.While the term“FL”was originally coined by the engineering community,the statistical field has also developed...
supported by the National Institutes of Health under Award Numbers R01GM139967,R21GM151703,and R21GM148931.
Background:Blood transfusions,crucial in managing anemia and coagulopathy in intensive care unit(ICU)settings,require accurate prediction for effective resource allocation and patient risk assessment.However,existing ...
supported by grants from the National Natural Science Foundation of China(72125009 and 82003529);National Key Research and Development Program of China(2022YFF1203001);National Key R&D Program of the Ministry of Science and Technology of China(2019YFC2005000);Young Elite Scientists Sponsorship Program by CAST(2022QNRC001);Chinese Scientiffc and Technical Innovation Project 2030(2018AAA0102100);CAMS Innovation Fund for Medical Sciences(2019-I2M-5-046),PKU-Baidu Fund(2020BD032);Shandong Natural Science Foundation General Project(ZR202211080088).
Background:Cancer is a major health problem worldwide.A growing number of cancer patients travel to hospitals outside their residential cities due to unbalanced medical resources.We aimed to evaluate the association b...
support is acknowledged from the National Science Fund for Distinguished Young Scholars of China(grant no.72125009);the National Key Research and Development Program of China(grant no.2022YFF1203000)received by L.Z.,the National Natural Science Foundation of China(grant no.82204137);Young Elite Scientists Sponsorship Program by CAST(grant no.2023QNRC001);Peking University Medicine Sailing Program for Young Scholars’Scientiffc&Technological Innovation(grant no.BMU2023YFJHMX014)received by F.Z.
Background:Previous studies suggested that smoking behavior(e.g.,smoking status)was associated with an elevated risk of chronic kidney disease(CKD),yet whether this association is causal remains uncertain.Methods:We u...
supported by the National Natural Science Foundation of China(No.62102008);the Peking University People’s Hospital Scientific Research Development Funds(RDJP2022-39);the Clinical Medicine Plus X-Young Scholars Project of Peking University,and the Fundamental Research Funds for the Central Universities(PKU2024LCXQ030).
Importance:Heart sound auscultation is a routinely used physical examination in clinical practice to identify potential cardiac abnormalities. However, accurate interpretation of heart sounds requires specialized trai...
supported by grants from the National Natural Science Foundation of China(72125009,82204137,and 82003529);National Key R&D Program of the Ministry of Science and Technology of China(2022YFF1203001);Young Elite Scientists Sponsorship Program by CAST(2022QNRC001 and 2023QNRC001)。
Importance:Climate change mitigation policies aimed at limiting greenhouse gas(GHG)emissions would bring substantial health co-benefits by directly alleviating climate change or indirectly reducing air pollution.As on...