《Research》

作品数：931被引量：1437H指数：14
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《Research》
主办单位：Science and Technology Review Publishing House
最新期次：2024年3期更多>>
发文主题：PEROVSKITEMATERIALSVERSATILEPRECISETUNABLE更多>>
发文领域：理学医药卫生一般工业技术自动化与计算机技术更多>>
发文基金：国家自然科学基金中国博士后科学基金高等学校学科创新引智计划国家重点基础研究发展计划更多>>
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Enhancing Generic Reaction Yield Prediction through Reaction Condition-Based Contrastive Learning
《Research》2024年第3期685-702,共18页Xiaodan Yin Chang-Yu Hsieh Xiaorui Wang Zhenxing Wu Qing Ye Honglei Bao Yafeng Deng Hongming Chen Pei Luo Huanxiang Liu Tingjun Hou Xiaojun Yao 
the Science and Technology Development Fund,Macao SAR(file nos.0056/2020/AMJ,0114/2020/A3,and 0015/2019/AMJ);Dr.Neher’s Biophysics Laboratory for Innovative Drug Discovery(file no.002/2023/ALC).
Deep learning(DL)-driven efficient synthesis planning may profoundly transform the paradigm for designing novel pharmaceuticals and materials.However,the progress of many DL-assisted synthesis planning(DASP)algorithms...
关键词：SYNTHESIS GENERIC holds 
Highly Strong,Tough,and Cryogenically Adaptive Hydrogel Ionic Conductors via Coordination Interactions
《Research》2024年第3期703-713,共11页Zhuomin Wang Siheng Wang Lei Zhang He Liu Xu Xu 
the National Natural Science Foundation of China(grant 31890774)to H.L;the Forestry Science and Technology Innovation and Extension Project of Jiangsu Province(grant LYKJ[2021]04)to H.L.
Despite the promise of high flexibility and conformability of hydrogel ionic conductors,existing polymeric conductive hydrogels have long suffered from compromises in mechanical,electrical,and cryoadaptive properties ...
关键词：HIGHLY FREEZING SALTS 
Access to Axially Chiral Aryl Aldehydes via Carbene-Catalyzed Nitrile Formation and Desymmetrization Reaction
《Research》2024年第3期715-721,共7页Yuanlin Cai Ya Lv Liangzhen Shu Zhichao Jin Yonggui Robin Chi Tingting Li 
the National Key Research and Development Program of China(2022YFD1700300);the National Natural Science Foundation of China(22071036);the Program of Introducing Talents of Discipline to Universities of China(111 Program,D20023)at Guizhou University;Frontiers Science Center for Asymmetric Synthesis and Medicinal Molecules,Department of Education,Guizhou Province[Qianjiaohe KY(2020)004];the Guizhou Province First-Class Disciplines Project[(Yiliu Xueke Jianshe Xiangmu)-GNYL(2017)008];Guizhou University(China);Singapore National Research Foundation under its NRF Investigatorship(NRF-NRFI2016-06)and Competitive Research Program(NRF-CRP22-2019-0002);Ministry of Education,Singapore,under its MOE AcRF Tier 1 Award(RG7/20,RG70/21),MOE AcRF Tier 2(MOE2019-T2-2-117),and MOE AcRF Tier 3 Award(MOE2018-T3-1-003);a Chair Professorship Grant;and Nanyang Technological University.
An approach utilizing N-heterocyclic carbene for nitrile formation and desymmetrization reaction is developed. The process involves kinetic resolution, with the axially chiral aryl monoaldehydes obtained in moderate y...
关键词：chemistry ALDEHYDES CHIRAL 
Traceable Lactate-Fueled Self-Acting Photodynamic Therapy against Triple-Negative Breast Cancer
《Research》2024年第3期723-733,共11页Yifan Zhang Guangle Feng Ting He Min Yang Jing Lin Peng Huang 
the National Key R&D Program of China(2018YFA0704000 and 2020YFA0908800);the National Natural Science Foundation of China(82372116,82071985,and 22104094);the Basic Research Program of Guangdong(2022A1515010620);the Basic Research Program of Shenzhen(JCYJ20200109105620482,JCYJ20220818095806014,and KQTD20190929172538530).
The depth of light penetration and tumor hypoxia restrict the efficacy of photodynamic therapy(PDT)in triple-negative breast cancer(TNBC),while the overproduction of lactate(LA)facilitates the development,aggressivene...
关键词：BREAST THERAPY MANGANESE 
Activable Photodynamic DNA Probe with an“AND”Logic Gate for Precision Skin Cancer Therapy被引量：2
《Research》2024年第3期735-750,共16页Jiaojiao Zhu Lanyuan Peng Shah Jehan Haiyang Wang Xiang Chen Shuang Zhao Wenhu Zhou 
the Natural Science Foundation of Hunan Province in China(2021JJ20084)and the Science and Technology Innovation Program of Hunan Province(2021RC3020).
Photodynamic therapy(PDT)has emerged as a promising approach for squamous cell carcinoma treatment but hindered by tumor hypoxia,acquired resistance,phototoxicity,and so on.To address these issues,we developed a smart...
关键词：SPECIFICITY thereby SKIN 
Morphology-Tailored Dynamic State Transition in Active-Passive Colloidal Assemblies
《Research》2024年第3期751-760,共10页Nan Yu Zameer H.Shah Mingcheng Yang Yongxiang Gao 
the Natural Science Foundation of Guangdong Province(Project No.2022A1515011800);the Science and Technology Innovation Commission of Shenzhen(JCYJ20220531103205012);the Key Project of Guangdong Provincial Department of Education(2023ZDZX3021);M.Y.acknowledges the support of the National Natural Science Foundation of China(Nos.12274448 and T2325027);the National Key R&D Program of China(No.2022YFF0503504).
Mixtures of active self-propelled and passive colloidal particles promise rich assembly and dynamic states that are beyond reach via equilibrium routes.Yet,controllable transition between different dynamic states rema...
关键词：TRANSITION otherwise TRANSITIONS 
Transferrin Is Up-Regulated by Microbes and Acts as a Negative Regulator of Immunity to Induce Intestinal Immunotolerance
《Research》2024年第3期761-774,共14页Xiaopeng Tang Mingqian Fang Ruomei Cheng Junkun Niu Xiaoshan Huang Kuanhong Xu Gan Wang Yang Sun Zhiyi Liao Zhiye Zhang James Mwangi Qiumin Lu Aili Wang Longbao Lv Chao Liu Yinglei Miao Ren Lai 
the National Key Research and Development Program of China(2022YFF1301601);the Ministry of Science and Technology of China(2018YFA0801403 and 2022YFC2105003);the National Science Foundation of China(31930015,32100907,U2002219,and 32371162);the Chinese Academy of Sciences(KFJ-BRP-008 and SAJC202103);Yunnan Province(202003AD150008,202202AA100002 and 202301AS070074);the Kunming Science and Technology Bureau(2022SCP007);the New Cornerstone Investigator Program from Shenzhen New Cornerstone Science Foundation,Excellent Young Scientists Foundation of Shandong Province(ZR2023YQ025);the Frontiers Medical Center,Tianfu Jincheng Laboratory Foundation(TFJC2023010007);the PI Project of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(GML2021GD0807).
Cross-talks (e.g., host-driven iron withdrawal and microbial iron uptake between host gastrointestinal tract and commensal microbes) regulate immunotolerance and intestinal homeostasis. However, underlying mechanisms ...
关键词：IMPAIRED IMMUNITY tolerance 
Mitochondrial-Oriented Injectable Hydrogel Microspheres Maintain Homeostasis of Chondrocyte Metabolism to Promote Subcellular Therapy in Osteoarthritis被引量：2
《Research》2024年第3期775-790,共16页Li Chen Jianye Yang Zhengwei Cai Yanran Huang Pengcheng Xiao Hong Chen Xiaoji Luo Wei Huang Wenguo Cui Ning Hu 
the National Natural Science Foundation of China(82072443 and 82372425);the China Postdoctoral Science Foundation(Grant No.2022M710557);the Natural Science Foundation of Chongqing,China(Grant No.CSTB2023NSCQ-BHX0011);the Young Excellent Science and Technology Talent Project of the First Affiliated Hospital of Chongqing Medical University(Grant No.ZYRC2022-05).
Subcellular mitochondria serve as sensors for energy metabolism and redox balance, and the dynamic regulation of functional and dysfunctional mitochondria plays a crucial role in determining cells' fate. Selective rem...
关键词：SPHERES REMOVE thereby 
Fiber Optic SPR POCT: A Novel Nucleic Acid Detection Biosensor for Environmental Viruses
《Research》2024年第3期791-793,共3页Jing Wang Zhaojun Duan Dixian Luo 
In the post-COVID-19 pandemic era, the long-term surveillance of pathogens is still important. The rapid detection of pathogens facilitates the accurate and convenient real-time monitoring of microbial contamination a...
关键词：POCT SPR CONVENIENT 
Biocompatible Biphasic Iontronics Enable Neuron-Like Ionic Signal Transmission
《Research》2024年第3期795-796,共2页Xiaoyi Wang Aleksandar P.Ivanov Joshua B.Edel 
Biocompatible connections between external artificial devices and living organisms show promise for future neuroprosthetics and therapeutics.The study in Science by Zhao and colleagues introduces a cascade-heterogated...
关键词：ASI SIGNAL NEURON 
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