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相关机构:浙江大学医学院附属第二医院中山大学复旦大学第四军医大学更多>>
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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology
《Neural Regeneration Research》2025年第9期2655-2666,共12页Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li Xiao-Jiang Li Su Yang 
supported by the National Key R&D Program of China,No.2021YFA0805200(to SY);the National Natural Science Foundation of China,No.31970954(to SY);two grants from the Department of Science and Technology of Guangdong Province,Nos.2021ZT09Y007,2020B121201006(both to XJL)。
Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto r.The mutant androgen r...
关键词:androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model NEURODEGENERATION neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor 
Prolonged consumption of dietary advanced lipoxidation end products contributes to renal impairment in mice through dysregulated intestinal homeostasis
《Food Science and Human Wellness》2025年第4期1291-1304,共14页Yaya Wang Lu Dong Yaozhong Hu Tianchang Zhang Ruican Wang Linqing Nie Junping Wang Yan Zhang Shuo Wang 
supported by grants from the National Natural Science Foundation of China(32030083)。
Heat processing of food has been well validated as the trigger to generate heat-processing side product of advanced lipoxidation end products(ALEs),which potentially engenders the threat on systemic health or progress...
关键词:Dietary advanced lipoxidation end products Renal insufficiency Gut microbiota Fecal metabolites Intestinal barrier AMPK/SIRT1 signaling pathway 
Ursolic acid inhibiting excessive reticulophagic flux contributes to alleviate ochratoxin A-induced endoplasmic reticulum stress-and mitochondrial-mediated apoptosis
《Food Science and Human Wellness》2025年第4期1318-1329,共12页Huiqiong Deng Wenying Chen Lingyun Han Boyang Zhang Xun Luo Song Yao Hongwei Wang Yao Zhou Shuangchao Liu Xiao Li Shen 
financially supported by the National Natural Science Foundation of China(82060598,32260587);the Natural Science Foundation of Guizhou Province(QKH-J-ZK[2021]181);the Scientific Research Program of Guizhou Provincial Department of Education(QJJ[2023]019);the Science&Technology Program of Guizhou Province(QKHPTRC-CXTD[2022]014);the Excellent Youth Talents of Zunyi Medical University(17zy-006);the Innovation and Entrepreneurship Training Program for College Students of Guizhou Province(S202210661138);the Innovation and Entrepreneurship Training Program for College Students of Zunyi Medical University(ZYDC2021108)。
Foods and animal feeds frequently become contaminated with the nephrotoxic ochratoxin A(OTA).Our prior research has indicated that ursolic acid(UA),which is widely present in fruits and medicinal plants,has the potent...
关键词:Ochratoxin A Ursolic acid Endoplasmic reticulum(ER)stress ER-phagy ER-phagic flux Apoptosis 
FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival
《Neural Regeneration Research》2025年第7期2108-2115,共8页Yuhui Kou Zongxue Jin Yusong Yuan Bo Ma Wenyong Xie Na Han 
supported by the National Natural Science Foundation of China,No.81971177(to YK);the Natural Science Foundation of Beijing,No.7222198(to NH);the Peking University People's Hospital Research and Development Fund,No.RDX2021-01(to YK)。
FK506(Tacrolimus)is a systemic immunosuppressant approved by the U.S.Food and Drug Administration.FK506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways ...
关键词:FK506 inflammation motor neurons nerve regeneration NEURON peripheral nerve injury sensory neurons 
SiPRR37 exerts dual functions in the regulation of photoperiodic flowering and contributes to the ecological adaption of foxtail millet
《The Crop Journal》2025年第2期339-349,共11页Liwei Wang Bao Tian Qiang He Guanqing Jia Bin Liu Qiong Lu Hui Zhi Xianmin Diao 
supported by the National Natural Science Foundation of China(32101759,32241042);the National Key Research and Development Program of China(2023YFD1200700 and 2023YFD1200704).
Foxtail millet(Setaria italica)is an important crop and an emerging model plant.Photoperiodic flowering is a key determinant of its production and geographic expansion.In this study,we found that SiPRR37 is responsibl...
关键词:Foxtail millet Photoperiodic flowering Ecological adaption Dual-function SiPRR37 
The OsSAPK10-OsPAL1 module contributes to rice blast resistance
《The Crop Journal》2025年第2期385-394,共10页Zhijuan Diao Houli Zhou Xun Wang Bangsheng Wang Ling Lu Na Xia Fanyu Kong Kexin Ji Sirui Xie Shengping Li Dingzhong Tang 
supported by National Key Research and Development Program of China(2023YFF1000500);the National Natural Science Foundation of China(32161133012).
The SnRK2 gene family plays important roles in ABA mediated abiotic stress responses.However,the roles and functional mechanism of the SnRK2 gene family in plant immunity are largely unknown.In this study,we report th...
关键词:OsSAPK10 OsPAL1 Rice blast resistance PHOSPHORYLATION SnRK2 
TRADD-mediated pyroptosis contributes to diabetic cardiomyopathy
《Acta Pharmacologica Sinica》2025年第4期940-950,共11页Yang-yang Zheng Dan-ning Shen Xiao-lu Peng Wen-qing San Qian-you Zhou Sheng-ju Yang Guo-liang Meng Jia-hai Shi Yun Chen 
supported by the National Natural Science Foundation of China(82200313,82070280,82270418,82370253);the“333 Project”of Jiangsu Province(2022-3-16-670);the Six Talent Peaks Project in Jiangsu Province(2018-WSN-062);Jiangsu Provincial Research Hospital(YJXYY202204);Innovation Team Project of Affiliated Hospital of Nantong University(XNBHCX31773).
Regulated cell death like pyroptosis is one vital cause of diabetic cardiomyopathy(DCM),which eventually leads to heart failure.Tumor necrosis factor(TNF)receptor-associated death domain protein(TRADD)is an adapter pr...
关键词:diabetic cardiomyopathy PYROPTOSIS TRADD XBP1 Apostatin-1 CARDIOMYOCYTE 
The Digital Shift Chinese company contributes to the technological revolution in Zambia’s mining sector
《ChinAfrica》2025年第4期23-25,共3页GE LIJUN 
In the digital control centre of the Chambishi copper mine’s southeast deposit in Zambia,a massive screen displays the status of various mining activities in real time:extraction,digging,machine operation,and transpo...
关键词:underground MINING SOUTHEAST 
Enhanced VOC emission with increased temperature contributes to the shift of O_(3)-precursors relationship and optimal control strategy
《Journal of Environmental Sciences》2025年第4期218-229,共12页Fangqi Qu Yuanjie Huang Yemin Shen Genqiang Zhong Yan Xu Lingling Jin Hongtao Qian Chun Xiong Fei Zhang Jiasi Shen Bingye Xu Xudong Tian Zhengning Xu Zhibin Wang 
supported by the National Natural Science Foundation of China(Nos.42005086,91844301,and 41805100);the National Key Research and Development Programof China(No.2022YFC3703500);China Postdoctoral Science Foundation(No.2023M733028);the Key Research and Development Program of Zhejiang Province(Nos.2021C03165 and 2022C03084);the Ecological and Environmental Scientific Research and Achievement Promotion Project of Zhejiang Province(No.2020HT0048).
Assessing the impact of anthropogenic volatile organic compounds(VOCs)on ozone(O_(3))formation is vital for themanagement of emission reduction and pollution control.Continuousmeasurement of O_(3)and the major precurs...
关键词:O_(3)pollution Volatile organic compounds Photochemical box model Source apportionment Optimal O_(3)control strategies 
Combustion-related isoprene contributes substantially to the formation of wintertime secondary organic aerosols
《National Science Review》2025年第3期153-164,共12页Yanli Zhang Yatai Men Hao Guo Guofeng Shen Yang Gao Rui Xiong Shu Tao Xinming Wang 
supported by the National Natural Science Foundation of China(42321003 to X.W.,42022023 to Y.Z);the Ministry of Science and Technology(2023YFE0112900 to G.S.),the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Y2021096 to Y.Z.);the Guangdong Science and Technology Programme(2023B1212060049 to X.W.);the Guangdong Major Project of Basic and Applied Basic Re-search(2023B0303000007 to X.W.);supported by the Center for Computational Science and Engineering at the Southern University of Science and Tech-nology.
Isoprene is a key reactive organic gas involved in organic aerosol formation.While biogenic isoprene from terrestrial plants has been extensively studied and is recognized as a major contributor to secondary organic a...
关键词:ISOPRENE combustion emission secondary organic aerosol(SOA) 
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