supported by Beijing Natural Science Foundation(Grant No.Z210014);National Natural Science Foundation of China(Grant No.32070543);National Key Research and Development Project of China(Grant No.2022YFC2303404);CAMS Innovation Fund for Medical Sciences(CIFMS)(Grant No.2022-12M-CoV19-002)
Background:SARS-CoV-2,first identified in late 2019,has given rise to numerous variants of concern(VOCs),posing a significant threat to human health.The emer-gence of Omicron BA.1.1 towards the end of 2021 led to a pa...