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作品数：3109被引量：9914H指数：32
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相关机构：首都医科大学第二军医大学复旦大学华中科技大学更多>>
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Microneedle technology in analgesic therapy
《Nano Research》2025年第2期488-502,共15页Jie Jiao Ze Qiang Zhao Yu Ting He Bin Bin Yu Kejun Chen Youchen Xia Ruixing Yu Bo Zhi Chen Xin Dong Guo 
This work was financially supported by the National Natural Science Foundation of China(Nos.52161145410,52373126,and 52303173);Beijing University of Chemical Technology-China Japan Friendship Hospital Biomedical Translational Engineering Research Center Key Projects(No.XK2023-20);Grant from State Key Laboratory of Organic-Inorganic Composites(No.oic 202401005);the Fundamental Research funds for the Central Universities(No.ZY2453);the long-term subsidy mechanism from the Ministry of Finance and the Ministry of Education of PRC.
Pain management has become a prominent global health concern,affecting not only over the aspects of daily existence but also upon the holistic physical well-being.Conventional pain management methods have non-negligib...
关键词：MICRONEEDLE pain management clinical analgesic trials LIDOCAINE 
Mito-specific cascade amplifier sniping metabolism homeostasis for multimodal imaging-guided antitumor bioenergetic therapy
《Nano Research》2024年第11期9908-9919,共12页Jingjing Yang Yuanlin Zhang Maoquan Chu Jin Qian Jie Liu Manyu Wang Zhe Qiang Jie Ren 
financially supported by the Shanghai 2020 “Science and Technology Innovation Action Plan” Social Development Science and Technology Research Project(No.20dz1203600);the Fundamental Research Funds for the Central Universities,and the Open Funds for Characterization of Tongji University.
Nicotinamide adenine dinucleotide (NAD+/NADH) pools homeostasis is recognized as an Achilles’ Heel in tumor metabolism reprogramming. However, mitochondria can enable cancer cells to overcome NADH exhaustion by provi...
关键词：metabolism programming nicotinamide adenine dinucleotide(NAD+/NADH)pools homeostasis disruption mitochondrial-targeting cascade therapy magnetic resonance imaging(MRI)/photoacoustic imaging(PAI) 
Valence-tailored copper-based nanoparticles for enhanced chemodynamic therapy through prolonged ROS generation and potentiated GSH depletion被引量：1
《Nano Research》2024年第7期6342-6352,共11页Xinyang Li Binbin Ding Jing Li Di Han Hao Chen Jia Tan Qi Meng Pan Zheng Ping’an Ma Jun Lin 
financially supported by the National Key Research and Development Program of China(No.2022YFB3804500);the National Natural Science Foundation of China(Nos.52102354,52102180,52202353,and 52372273);the Science and Technology Development Planning Project of Jilin Province(Nos.20220101070JC,20220508089RC,and 20210402046GH).
Chemodynamic therapy(CDT),an inventive approach to cancer treatment,exploits innate chemical processes to trigger cell death through the generation of reactive oxygen species(ROS).While offering advantages over conven...
关键词：CuPd nanoparticle ferroptosis chemodynamic therapy valance tailoring tumor therapy 
Multifunctional electroactive bio-adhesive for robustly-integrated wound therapy and postoperative wound-status warning and assessment
《Nano Research》2024年第5期4359-4370,共12页Ouyang Yue Xuechuan Wang Mengdi Hou Siwei Sun Manhui Zheng Xiaoliang Zou Zhongxue Bai Chunlin Liu Xinhua Liu 
supported by Fellowship of China Postdoctoral Science Foundation(No.2023M732159);the National Natural Science Foundation of China(Nos.22308209 ,2207081675);Key R&D Program of Shaanxi Province(No.2022GY-272);Young Talent Support Program Project of Shaanxi University Science and Technology Association(No.20200424).
Wound abnormalities such as secondary wound laceration and inflammation are common postoperative health hazards during clinical procedures.The continuous treatment,healing induction,and real-time visualization of woun...
关键词：electroactive bio-adhesive quadruple energy dissipation comprehensive wound therapy postoperative wound-status warning and assessment 
Engineered plant extracellular vesicles for autoimmune diseases therapy被引量：4
《Nano Research》2024年第4期2857-2873,共17页Ruina Han Yan Wu Yafei Han Xiangfei Liu Han Liu Jiacan Su 
supported by the National Natural Science Foundation of China(Nos.82230071,and 82202344);Integrated Project of Major Research Plan of National Natural Science Foundation of China(No.92249303);Shanghai Committee of Science and Technology Laboratory Animal Research Project(No.23141900600).
Autoimmune diseases(AID)encompass a diverse array of conditions characterized by immune system dysregulation,resulting in aberrant responses of B cells and T cells against the body’s own healthy tissues.Plant extrace...
关键词：autoimmune diseases plant extracellular vesicles extracellular vesicles engineering modification 
Oral pyroptosis nanoinhibitor for the treatment of inflammatory bowel disease
《Nano Research》2024年第3期1748-1759,共12页Zhenxing Zhu Dongtao Zhou Yi Yin Zhun Li Zhen Guo Yongchun Pan Yanfeng Gao Jingjing Yang Weiming Zhu Yujun Song Yi Li 
supported by the National Natural Science Foundation of China(Nos.82270543,82170573,81770556 and 21874066);the National Key R&D Program of China(No.2019YFA0709200);the Key Research and Development Program of Jiangsu Province(No.BE2021373);the Natural Science Foundation of Jiangsu Province(No.BK20200336);the Fundamental Research Funds for Central Universities,and the Program for Innovative Talents and Entrepreneur in Jiangsu.All animal studies were approved by the Ethics Committee of Jinling Hospital(No.2021JLHDWLSZ-0010);Surgical specimens were collected from Department of Gastroenterology and Hepatology,General Hospital of Eastern Theater Command.The use of human biopsies was approved by the Ethics Committee of Jinling Hospital(No.2022DZKY-048-01).All patients enrolled were given informed written consent.
Inflammatory bowel disease(IBD)is an autoimmune gastrointestinal disease characterized by chronic relapsing inflammation of the intestine.Excessive pyroptosis that exists in the inflamed intestine can activate damage ...
关键词：inflammatory bowel disease nanoinhibitors PYROPTOSIS synergistic therapy ANTIOXIDANT 
Pd@Ir-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy被引量：1
《Nano Research》2024年第1期270-281,共12页Zichen Ye Yun Li Jingchao Li Xinyan Hu Jinyang Zheng Gongxin Zhang Sijin Xiang Tianbao Zhu Zhide Guo Xiaolan Chen 
supported by the National Natural Science Foundation of China(No.22075233);Natural Science Foundation of Fujian Province(No.2022J01023).
Lactic acid(LA)plays a major role in the occurrence,development,and spread of cancer.Enlightened by its high accumulation in tumor site,a novel lactate oxidase(LOD)conjugated two-dimensional Pd@Ir nanoplatform(Pd@Ir-L...
关键词：lactate oxidase chemodynamic therapy photothermal therapy cascade reaction tumor microenvironment 
Reprogramming the tumor immune microenvironment via nanomaterial-mediated dynamic therapy
《Nano Research》2023年第12期13100-13112,共13页Wangbo Jiao Yao Feng Chen Liang Qiaoyi Lu Haiming Fan Xing-Jie Liang Xiaoli Liu 
supported by the National Key Research and Development Program of China(No.2022YFC2408000);the National Natural Science Foundation of China(NSFC)(Nos.82072063,32001005,32101136,and 82202306);Key Research and Development Program of Shaanxi Province(No.2023-YBSF-132);Shaanxi Province Youth Science and Technology New Star(No.2022KJXX-09);Natural Science Foundation of Shaanxi Province(No.2020JQ610);Science Foundation of Nanjing Chia Tai Tianqing project(No.TQ202215).
Our improved knowledge of tumor immunology laid a solid foundation for the clinical use of tumor immunotherapies such as immune checkpoint blockers,and the efficacy of these drugs increased our confidence that immunom...
关键词：tumor immunotherapy tumor immune microenvironment NANOMATERIALS reactive oxygen species immune cells 
Glioma cell membrane camouflaged cinobufotalin delivery system for combinatorial orthotopic glioblastoma therapy被引量：1
《Nano Research》2023年第8期11164-11175,共12页Zibin Song Liqian Zhao Weiyi Fang Siyun Guo Anqi Xu Zhengming Zhan Yonghua Cai ShuaiShuai Xue Peng Chai Qiuhua Jiang Peng Zhao Ye Song 
supported by the National Natural Science Foundation of China(Nos.81872064 and 82272879);the Natural Science Fund of Guangdong Province,China(No.2021A1515012465);Technology Program of Guangzhou(No.202206010068);Major Discipline and Academic Leader Training Program of Jiangxi Province(No.20225BCJ23001).
Glioblastoma(GBM)belongs to the deadliest primary malignancies with high mortality rate and poor prognosis.Over the past decades,less progress has been made to treat GBM,owing largely to the lack of effective chemothe...
关键词：GLIOBLASTOMA cinobufotalin biomimetics photothermal therapy blood-brain barrier 
Spatially asymmetric cascade nanocatalysts for enhanced chemodynamic therapy
《Nano Research》2023年第7期9642-9650,共9页Minchao Liu Hongyue Yu Liang Chen Tiancong Zhao Meng Fang Mengli Liu Qiaoyu Zhou Fatemah Farraj AlHarbi Ahmed Mohamed El-Toni Fan Zhang Dongyuan Zhao Xiaomin Li 
This work is supported by the National Natural Science Foundation of China(Nos.22075049,21875043,22088101,21701027,21733003,21905052,and 51961145403);the National Key R&D Program of China(Nos.2018YFA0209401 and 2018YFE0201701);Key Basic Research Program of Science and Technology Commission of Shanghai Municipality(No.17JC1400100);Natural Science Foundation of Shanghai(Nos.22ZR1478900,18ZR1404600,and 20490710600);Fundamental Research Funds for the Central Universities(20720220010);Shanghai Rising-Star Program(No.20QA1401200);The authors express their gratitude to Princess Nourah bint Abdulrahman University Researchers Supporting Project number(PNURSP2023R55);Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.The statements made herein are solely the responsibility of the authors。
Chemodynamic therapy(CDT)based on cascade catalytic nanomedicine has emerged as a promising cancer treatment strategy.However,most of the reported cascade catalytic systems are designed based on symmetric-or co-assemb...
关键词：MESOPOROUS nanocatalytic medicine chemodynamic therapy asymmetric nanostructure core@shell 
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