Γ-BUTYROLACTONE

作品数：25被引量：39H指数：4
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相关领域：理学化学工程更多>>
相关作者：秦迎松雷爱文更多>>
相关机构：武汉大学中国医科大学更多>>
相关期刊：《China Petroleum Processing & Petrochemical Technology》《Precision Chemistry》《Chinese Journal of Chemistry》《Science China(Life Sciences)》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划高等学校学科创新引智计划国家科技支撑计划更多>>
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Small moleculeα-methylene-γ-butyrolactone,an evolutionarily conserved moiety in sesquiterpene lactones,ameliorates arthritic phenotype via interference DNA binding activity of NF-κB
《Acta Pharmaceutica Sinica B》2024年第8期3561-3575,共15页Kegang Linghu Wenqing Cui Taiqin Li Yueting Tuo Dasong Wang Huiqi Pan Tian Zhang Ligen Lin Hua Yu Xiaoxia Hu Haiyang Li Xiangchun Shen 
support by the National Natural Science Foundation of China(82260801);China Postdoctoral Science Foundation(2023M730815,China);Excellent Young Talents Plan of Guizhou Medical University(2023110,China);the Guizhou Provincial Scientific and Technologic Innovation Base([2023]003,China);the High Level Innovation Talents(GCC[2023]048,China);Science and Technology Development Fund,Macao SAR(0159/2020/A3,China);Guizhou Provincial Science and Technology Project(ZK[2024]152,China);Guizhou Provincial Health Commission Science and Technology Foundation(gzwkj2023-153,China)are gratefully acknowledged.
Rheumatoid arthritis(RA)is an inflammatory disease accompanied by abnormal synovial microenvironment(SM).Sesquiterpene lactones(SLs)are the main anti-inflammatory ingredients of many traditional herbs utilized in RA t...
关键词：a-Methylene-gbutyrolactone Rheumatoid arthritis NF-κB p65 Synovial microenvironment Sesquiterpene lactones 
Tackling application limitations of high-safetyγ-butyrolactone electrolytes:Exploring mechanisms and proposing solutions
《Journal of Energy Chemistry》2024年第6期193-201,I0005,共10页Haojun Wu Zhangyating Xie Guanjie Li Lei Zheng Zhiwei Zhao Jiarong He Yanbin Shen Jiahao Hu Zhangquan Peng Guiming Zhong Lidan Xing Weishan Li 
financially supported by the National Natural Science Foundation of China(21972049,22272175);the National Key R&D Program of China(2022YFA1504002);the“Scientist Studio Funding”from Tianmu Lake Institute of Advanced Energy Storage Technologies Co.,Ltd.;Dalian Supports High-Level Talent Innovation and Entrepreneurship Projects(2021RD14);the Dalian Institute of Chemical Physics(DICP I202213);the 21C Innovation Laboratory,Contemporary Ampere Technology Ltd.by project No.21C-OP-202208。
Developing wide-temperature and high-safety lithium-ion batteries(LIBs)presents significant challenges attributed to the absence of suitable solvents possessing broad liquid range and non-flammability properties.γ-Bu...
关键词：γ-Butyrolactone/Graphite incompatibility Unique solvation structure SEI film Lithium-ion batteries 
Continuous-flow synthesis of polysubstituted γ-butyrolactones via enzymatic cascade catalysis被引量：1
《Chinese Chemical Letters》2024年第4期404-408,共5页Liliang Chu Xiaoyan Zhang Jianing Li Xuelei Deng Miao Wu Ya Cheng Weiping Zhu Xuhong Qian Yunpeng Bai 
financially sponsored by the National Key Research and Development Program of China (No.2021YFC2102804);the National Natural Science Foundation of China(No.22078096)。
Polysubstituted chiral γ-butyrolactones are the core structural units of many natural products and high value-added flavors and fragrances used in the food and cosmetic industry. Current enzymatic cascade synthesis o...
关键词：Enzyme catalysis Cascade catalysis Directed evolution CONTINUOUS-FLOW γ-Butyrolactones 
γ-Butyrolactone Synthesis from Allylic Alcohols Using the CO_(2)Radical Anion
《Precision Chemistry》2024年第3期88-95,共8页Saeesh R.Mangaonkar Hiroki Hayashi Wataru Kanna Suvankar Debbarma Yu Harabuchi Satoshi Maeda Tsuyoshi Mita 
This work was financially supported by JST-ERATO(JPMJER1903);Scientific Research(B)(22H02069);Transformative Research Areas(A)(Digitalization-driven Transformative Organic Synthesis(Digi-TOS))(22H05330).T.M.thanks the Naito Foundation for financial support.
γ-Butyrolactone structures are commonly found in various natural products and serve as crucial building blocks in organic synthesis.Consequently,the development of methods for synthesizingγ-butyrolactones has garner...
关键词：CO_(2) LACTONE RADICAL PHOTOREDOX visible light CARBOXYLATION calculation DFT 
Stereodivergent synthesis ofα-fluoroα-azaarylγ-butyrolactones via cooperative copper and iridium catalysis被引量：1
《Fundamental Research》2024年第1期77-85,共9页Kui Tian Xin Chang Lu Xiao Xiu-Qin Dong Chun-Jiang Wang 
We are grateful for financial support from the National Key R&D Program of China(2023YFA1506700);National Natural Science Foundation of China(22071186,22071187,22101216,22271226,and 22371216);Natural Science Foundation of Hubei Province(2020CFA036,2021CFA069);Natural Science Foundation of Jiangsu Province(BK20190213);China Postdoctoral Science Foundation(2021M702514);National Youth Talent Support Program,and Fundamental Research Funds for the Central Universities(2042022kf1180).
The development of stereodivergent synthetic methods to access all four stereoisomers of biologically importantα-fluoroγ-butyrolactones containing vicinal stereocenters is of great importance and poses a formidable ...
关键词：Asymmetric catalysis α-Fluoroγ-butyrolactones Synergistic catalysis Cascade reaction Stereodivergent synthesis 
Organocatalytic enantioselective construction of bicyclic γ-butrolactones
《Chinese Chemical Letters》2023年第7期122-126,共5页Qiang Zhang Jingxiang Pang Tian-Zhang Wang Feng Chen Minghao Shen Tianyu Li Yongshuai Chai Yu-Feng Liang Jie Sun Zhushuang Bai 
National Natural Science Foundation of China (Nos. 21877005, 21907059, 22001147);Taishan Scholars Project of Shandong Province (No. tsqn202103027);Distinguished Young Scholars of Shandong Province (Overseas) (No. 2022HWYQ-001);Academic Promotion Programme of Shandong First Medical University (No. 2019LJ003);Natural Science Foundation of Shandong Province (No. ZR2021MB102) for financial support。
An enantioselective organo-catalyzed reaction of furanones with α,β-unsaturated ketones has been established herein, which provides an efficient access to chiral bicyclic γ-butyrolactones in good yields, enantiosel...
关键词：ORGANOCATALYST Asymmetric synthesis Bicyclicγ-butyrolactone DIAMINE CYCLIZATION 
Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases被引量：9
《Acta Pharmaceutica Sinica B》2023年第2期678-693,共16页Haowen Xu Jiahao Chen Pan Chen Weifeng Li Jingjing Shao Shanshan Hong Yi Wang Lingfeng Chen Wu Luo Guang Liang 
supported by the National Natural Science Foundation of China(81930108 to Guang Liang,82000793 to Wu Luo,and 82170373 to Yi Wang);Natural Science Foundation of Zhejiang Province(LY22H070004 to Wu Luo,China);Zhejiang Provincial Key Scientific Project(2021C03041 to Guang Liang,China);Wenzhou Scientific Project in China(Y20210213 to Wu Luo)。
The NLRP3 inflammasome’s core and most specific protein,NLRP3,has a variety of functions in inflammation-driven diseases.Costunolide(COS)is the major active ingredient of the traditional Chinese medicinal herb Saussu...
关键词：COSTUNOLIDE NLRP3 inflammasome Inflammation Molecular target NACHT domain α-Methylene-γ-butyrolactone Gouty arthritis Ulcerative colitis 
Fully Chemical Recyclable Poly(γ-butyrolactone)-based Copolymers with Tunable Structures and Properties
《Chinese Journal of Polymer Science》2022年第5期456-461,共6页Yi-Huan Liu Xin Yuan Jia-Qi Wu Ming-Xuan Luo Xin Hu Ning Zhu Kai Guo 
financially supported by the National Natural Science Foundation of China(Nos.22078150 and 21504039)。
The emerging chemical recyclable polymers,such as poly(γ-butyrolactone)(PGBL)and poly((R)-3,4-trans six-membered ring-fused GBL)(P((R)-M)),provide a good solution to the plastic pollution.However,these homopolymers s...
关键词：Poly(γ-butyrolactone)-based copolymers Ring-opening copolymerization Chemical recyclability Organomagnesium 
NHC-catalysed[3+2]-asymmetric annulation between pyrazolin-4,5-diones and enals:synthesis of novel spirocyclic pyrazolone γ-butyrolactones and computational study of mechanism and stereoselectivity
《Organic Chemistry Frontiers》2022年第2期420-427,共8页Marta Gil-Ordonez Alicia Maestro Pablo Ortega Pablo G.Jambrina Jose M.Andres 
Junta de Castilla y León(Projects:FEDER-VA115P17,and VA149G18)for financial support;the Laboratory of Instrumental Techniques(LTI)Research Facilities,Universidad de Valladolid;Junta de Castilla y León for a predoctoral fellowship(EDU/556/2019);grant PID2020-113147GA-I00 funded by MCIN/AEI/10.13039;by the Fundación Salamanca City of Culture and Knowledge(programme for attracting scientific talent to Salamanca);Grant No.EDU/601/2020(Junta de Castilla y Leon and European Social Fund).
Chiral pyrazolones with a spirocyclic centre at the C4-position are widely found in a large family of medically relevant compounds.In recent years,organocatalysis,particularly that performed with quiral N-heterocyclic...
关键词：synthesis spiro mechanism 
A widespread response of Gram-negative bacterial acyl-homoserine lactone receptors to Gram-positive Streptomyces γ-butyrolactone signaling molecules被引量：3
《Science China(Life Sciences)》2021年第10期1575-1589,共15页Xiang Liu Wenxi Wang Junyue Li Yue Li Jihui Zhang Huarong Tan 
supported by the National Key Research and Development Program of China(2018YFA0901900 and 2020YFA0907700);the National Natural Science Foundation of China(31771378 and 31800029)。
Cell-cell communication is critical for bacterial survival in natural habitats,in which miscellaneous regulatory networks are encompassed.However,elucidating the interaction networks of a microbial community has been ...
关键词：signaling communication CROSS-TALK Gram-positive bacteria STREPTOMYCES Γ-BUTYROLACTONE Gram-negative bacteria acyl-homoserine lactone synthetic biology combinatorial regulatory circuit 
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