SIGNALINGPATHWAY

作品数：10被引量：46H指数：5
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相关领域：医药卫生更多>>
相关作者：于小龙周鑫付长林王强戴闽更多>>
相关机构：广州军区武汉总医院上海市伤骨科研究所北京世纪坛医院南昌大学第一附属医院更多>>
相关期刊：《Acta Biochimica et Biophysica Sinica》《Chinese Journal of Integrative Medicine》《World Journal of Gastroenterology》《Chinese Medical Journal》更多>>
相关基金：国家自然科学基金上海市青年科技启明星计划国家重点基础研究发展计划更多>>
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Zhizhu Decoction Alleviates Intestinal Barrier Damage via Regulating SIRT1/FoxO1 Signaling Pathway in Slow Transit Constipation Model Mice被引量：5
《Chinese Journal of Integrative Medicine》2023年第9期809-817,共9页WEN Yong ZHAN Yu TANG Shi-yu LIU Fang WANG Qiu-xiao KONG Peng-fei TANG Xue-gui 
Supported by the General Project of National Natural Science Foundation of China(No.82074429)。
Objective:To explore the possible effects and mechanism of Zhizhu Decoction(ZZD)on the pathophysiology of slow transit constipation(STC).Methods A total of 54 C57BL/6 mice was randomly divided into the following 6 gro...
关键词：ZhizhuDecoction intestinal barrier slow transit constipation oxidative stress silent information regulator 1/forkhead box O transcription factor1signalingpathway 
Amygdalin Ameliorates Liver Fibrosis through Inhibiting Activation of TGF-β/Smad Signaling被引量：9
《Chinese Journal of Integrative Medicine》2023年第4期316-324,共9页XIAO Zhun JI Qiang FU Ya-dong GAO Si-qi HU Yong-hong LIU Wei CHEN Gao-feng MU Yong-ping CHEN Jia-mei LIU Ping 
Supported by National Natural Science Foundation of China(Nos.81530101,81973613 and 81603681);Shanghai Rising-Star Program(No.19QA1408900)。
Objective:To observe the effect of amygdalin on liver fibrosis in a liver fibrosis mouse model,and the underlying mechanisms were partly dissected in vivo and in vitro.Methods:Thirty-two male mice were randomly divide...
关键词：AMYGDALIN liver fibrosis hepatic stellate cells liver sinusoidal endothelial cells TGF-β/Smad signalingpathway 
A transposon-introduced G-quadruplex motif is selectively retained and constrained to downregulate CYP321A1
《Insect Science》2022年第6期1629-1642,共14页Zhongyuan Deng Yuting Zhang Chao Gao Wei Shen Shan Wang Xinzhi Ni Sisi Liu Xianchun Li 
supported by the National Natural Science Foundation of China(No.31701791);National Science Foundation of China(NSFC)-Henan Joint major grant(No.U2004206);the State Key Laboratory of Cotton Biology(No.CB2020A06);the USDA National Institute of Food and Agriculture Hatch Project(No.ARZT-1370680-R31-R31-172).
Insects utilize xenobiotic compounds to up-and downregulate cytochrome P450 monooxygenases(P450s)involved in detoxification of toxic xenobiotics including phytochemicals and pesticides.G-quadruplexes(G4)-forming DNA m...
关键词：DNA secondary structure gene regulation Helicoverpa zea natural selec-tion plantallelochemicals SIGNALINGPATHWAY SILENCER 
Biological Function and Mechanism of Long Noncoding RNAs Nuclear-Enriched Abundant Transcript I in Development of Cervical Cancer被引量：5
《Chinese Medical Journal》2018年第17期2063-2070,共8页Hui-Ling Wang Shun-Yu Hou Hai-Bo Li Jian-Ping Qiu Le Bo Cai-Ping Mao 
This study was supported by grants from the National Natural Science Foundation of China （No. 81370719 and No. 81671535）, the Science Foundation of Jiangsu （No. BE2015642, and No. WSW023）, the Jiangsu Key Discipline of Human Assisted Reproduction Medicine Foundation （No. FXK201749）, and the Jiangsu Provincial Medical Youth Talent of the Project of Invigorating Health Care through Science, Technology, and Education （No. ZDRCA2016044）.
Background： Accumulating documents have demonstrated that long noncoding RNAs （lncRNAs） play critical roles in tumorigenesis. As an lncRNA, nuclear-enriched abundant transcript 1 （NEAT1） has been identified to be...
关键词：Cervical Cancer Long Noncoding RNA Nuclear-Enriched Abundant Transcript 1 Migration PI3K/Akt SignalingPathway Proliferation 
ROCK inhibition enhances neurite outgrowth in neural stem cells by upregulating YAP expression in vitro被引量：2
《Neural Regeneration Research》2016年第6期983-987,共5页Xu-feng Jia Fei Ye Yan-bo Wang Da-xiong Feng 
supported by the National Natural Science Foundation of China(General Program),No.30872602
Spontaneous axonal regeneration of neurons does not occur after spinal cord injury because of inhibition by myelin and other inhibitory factors. Studies have demonstrated that blocking the Rho/Rho-kinase （ROCK） path...
关键词：nerve regeneration spinal cord injury neural stem cells Rho signalingpathway neurite outgrowth MYELIN YAP neural regeneration 
Group Ⅱ p21-activated kinases as therapeutic targets in gastrointestinal cancer被引量：2
《World Journal of Gastroenterology》2016年第3期1224-1235,共12页Yang-Guang Shao Ke Ning Feng Li 
Supported by National Natural Science Foundation of China;No.90813038;No.31271389;No.31371424;No.31171360 and No.81230077
P21-activated kinases(PAKs) are central players in various oncogenic signaling pathways. The six PAK family members are classified into group Ⅰ(PAK1-3) and group Ⅱ(PAK4-6). Focus is currently shifting from group Ⅰ ...
关键词：GROUP Ⅱ p21-activated KINASES SIGNALINGPATHWAY GASTROINTESTINAL cancer PAK4 INHIBITOR Drugtarget 
The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system被引量：12
《Neural Regeneration Research》2015年第11期1892-1896,共5页Jing Liu Hong-yan Gao Xiao-feng Wang 
supported by a grant from the National Natural Science Foundation of China;No.81471087;81170577
The Rho/Rho-associated coiled-coil containing protein kinase（Rho/ROCK） pathway is a major signaling pathway in the central nervous system, transducing inhibitory signals to block regeneration. After central nervous ...
关键词：nerve regeneration Rho/Rho-associated coiled-coil containing protein kinase SIGNALINGPATHWAY axonal regeneration central nervous system microenvironment REVIEWS NSFC grant neural regeneration 
Cell therapy in diabetes: current progress and future prospects被引量：3
《Science Bulletin》2015年第20期1744-1751,共8页Ying Wang Tang Hai Lei Liu Zhonghua Liu Qi Zhou 
supported by the National Basic Research Program of China(2013CB967102);the National Natural Science Foundation of China(31201112)
Diabetes mellitus, characterized by the impaired metabolism of insulin secretion in β cells, is becoming one of the most prevalent diseases around the world. Recently, cell replacement based on differentiation of var...
关键词：DIABETES Cell therapy SIGNALINGPATHWAY XENOTRANSPLANTATION 
Vascular endothelial growth factor induces multidrug resistance-associated protein 1 overexpression through phosphatidylinositol-3-kinase/protein kinase B signaling pathway and transcription factor specificity protein 1 in BGC823 cell line被引量：2
《Acta Biochimica et Biophysica Sinica》2013年第8期656-663,共8页Juan Li Xiaojun Wu Jinling Gong Jing Yang Jiayan Leng Qiaoyun Chen Wenlin Xu 
Multidrug resistance （MDR） is one of the most important causes of chemotherapy failure and carcinoma recurrence. But the roles of the MDR-associated protein MRP1 in MDR remain poorly understood. Vascular endothelial...
关键词：cancer VEGF MRP1 PI3K/AKT signalingpathway SP1 
Involvement of Endoplasmic Reticulum Stress in Apoptosis of Testicular Cells Induced by Low-dose Radiation被引量：7
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2013年第4期551-558,共8页王志成 王剑锋 李艳博 郭彩霞 刘扬 方芳 龚守良 
supported by the grants from the National Natural Science Foundation of China(No.30970681);Basic Research and Operating Expenses of Jilin University(No.200903116)
Summary： The study examined the role of endoplasmic reticulum stress （ERS） and signaling pathways of inositol-requiring enzyme-1 （IRE1）, RNA-activated protein kinase-like ER kinase （PERK） and activating transcr...
关键词：low dose radiation testicular cells endoplasmic reticulum stress APOPTOSIS SIGNALINGPATHWAY 
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