NON-NUCLEOSIDE

作品数：19被引量：38H指数：3
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相关领域：医药卫生更多>>
相关作者：王孝伟张志丽刘俊义郭盈闫寒更多>>
相关机构：北京大学九江学院更多>>
相关期刊：《Acta Pharmacologica Sinica》《Science China Chemistry》《World Journal of Gastroenterology》《Journal of Chinese Pharmaceutical Sciences》更多>>
相关基金：国家自然科学基金北京市自然科学基金国家教育部博士点基金更多>>
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Linker optimization of HEPT derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors: From S=O to CHOR
《Chinese Chemical Letters》2023年第4期188-192,共5页Qingqing Hao Xu Ling Christophe Pannecouque Erik De Clercq Fener Chen 
financially supported by National Natural Science Foundation of China (No. 22077018);National Key R&D Program of China (No. 2017YFA0506000)。
A novel series of CHOR-HEPT non-nucleoside HIV-1 reverse transcriptase inhibitors were developed by means of structure-based design strategy based on compound 6 reported previously by our group. Most of these compound...
关键词：HIV NNRTIS HEPTs RT OPTIMIZATION 
Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase被引量：8
《Acta Pharmaceutica Sinica B》2021年第6期1555-1567,共13页Quanjie Li Dongrong Yi Xiaobo Lei Jianyuan Zhao Yongxin Zhang Xiangling Cui Xia Xiao Tao Jiao Xiaojing Dong Xuesen Zhao Hui Zeng Chen Liang Lili Ren Fei Guo Xiaoyu Li Jianwei Wang Shan Cen 
supported by the National MegaProject for Infectious Disease (2018ZX10301408, China);the National Mega-Project for Significant New Drug Discovery (2018ZX09711003-002-002, China);the National Natural Science Foundation of China (81802019 and 81902075);the Beijing Natural Science Foundation (7184228, China);CAMS Innovation Fund for Medical Sciences (2018-I2M-3-004 and 2020-I2M-2010, China);the Peking Union Medical College Youth Fund (3332016063 and 3332018096, China)。
Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) has become one major threat to human population health.The RNA-dependent RNA polymerase(RdRp) presents an ideal target of antivirals,whereas nucleoside analo...
关键词：SARS-CoV-2 RDRP Structure-based virtual screening Viral replication Non-nucleoside inhibitor Drug combinations CORILAGIN 
Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors被引量：1
《Chinese Chemical Letters》2021年第3期1020-1024,共5页Daxiong Li Chunsheng Zhang Wei Ding Siming Huang Le Yu Nan Lu Wenkai Pan Yiming Li Erik De Clercq Christophe Pannecouque Hongbing Zhang Yueping Wang Yanping He Fener Chen 
financial support from the National Natural Science Foundation of China(Nos.21967020,U1702286,21362017,21262044);Program for Changjiang Scholars and Innovative Research Team in University(No.IRT17R94,China);Fund of Academician Working Station of Yunnan Province(No.2018IC057)。
In continuation of our efforts toward the discovery of potent HIV-1 NNRTIs with diverse structures,a series of novel S-DACO analogues of 6-(2-cyclohexyl-1-allkyl)-2-(2-oxo-2-phenyl-ethylsulfanyl)pyrimidin-4(3 H)-ones ...
关键词：NNRTIS S-DABOs S-DACOs Anti HIV-1 activity SAR 
Improving the positional adaptability:structurebased design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors被引量：4
《Acta Pharmaceutica Sinica B》2020年第2期344-357,共14页Kaijun Jin Minjie Liu Chunlin Zhuang Erik De Clercq Christophe Pannecouque Ge Meng Fener Chen 
financially supported by National Natural Science Foundation of China under Grant Nos.21871055 and21372050;Shanghai Municipal Natural Science Foundation under Grant No.13ZR1402200(China).
In order to improve the positional adaptability of our previously reported naphthyl diaryltriazines(NP-DATAs),synthesis of a series of novel biphenyl-substituted diaryltriazines(BP-DATAs)with a flexible side chain att...
关键词：HIV-1 NNRTIS NP-DATAs BP-DATAs Positional ADAPTABILITY Molecular modeling 
Highly active antiretroviral therapy dysregulates proliferation and differentiation of human pre-adipocytes被引量：3
《World Journal of Virology》2017年第3期53-58,共6页Eyone Jones Pavel Mazirka Margaret A McNurlan Frank Darras Marie C Gelato Giuseppe Caso 
AIM To investigate the mechanism(s) by which potential effects of multi-drug highly-active antiretroviral therapy contributes to lipodystrophy syndrome. METHODS Preadipocytes from healthy donors were assessed for prol...
关键词：Nucleoside REVERSE transcriptase INHIBITORS NON-NUCLEOSIDE REVERSE transcriptase INHIBITORS Protease INHIBITORS Pre-adipocytes Highly active antiretroviral therapy LIPODYSTROPHY 
Emerging antivirals for the treatment of hepatitis B被引量：3
《World Journal of Gastroenterology》2014年第24期7707-7717,共11页Xue-Yan Wang Hong-Song Chen 
Supported by National Natural Science Foundation of China,No.31340023,No.91029741,No.81001072 and No.81171550;National Key Sci-Tech Special Project of China,No.2012ZX10002011-006;Specialized Research Fund for the Doctoral Program of Higher Education,No.20130001120075;Peking University People’s Hospital Research and Development Funds,No.RDB2013-02
Chronic infection with hepatitis B virus(HBV)constitutes a major global public health threat,causing substantial disease burdens such as liver cirrhosis and hepatocellular carcinoma,thus representing high unmet medica...
关键词：Hepatitis B ANTIVIRAL Nucleoside analogue Nucleotide analogue Non-nucleoside antivirals 
Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation被引量：15
《Acta Pharmacologica Sinica》2014年第3期410-418,共9页Li YANG Li-ping SHI Hai-jun CHEN Xian-kun TONG Gui-feng WANG Yang-ming ZHANG Wen-long WANG Chun-lan FENG Pei-lan HE Feng-hua ZHU You-hua HAO Bao-ju WANG Dong-liang YANG Wei TANG Fa-jun NAN Jian-ping ZUO 
Aim： To investigate the action of isothiafludine （NZ-4）, a derivative of bis-heterocycle tandem pairs from the natural product leucamide A, on the replication cycle of hepatitis B virus （HBV） in vitro and in vivo...
关键词：hepatitis B virus replication capsid assembly pregenomic RNA non-nucleoside compound isothiafludine lamivudine ADEFOVIR ENTECAVIR 
Synthesis and biological evaluation of novel 2-arylalkylthio-5-iodo-6-benzyl S-DABOs as potent non-nucleoside HIV-1 reverse transcriptase inhibitors被引量：1
《Journal of Chinese Pharmaceutical Sciences》2012年第1期28-32,共5页Liang Zhang Xiao-Wei Wang Jun-Yi Liu 
National Natural Science Foundation of China (GrantNo.20972011,21042009)
A series of novel dihydro-alkylthio-benzyl-oxopyrimidines （S-DABOs） 7a-f have been designed and synthesized with an efficient method. Biological evaluation of their HIV-1 reverse transcriptase inhibitory activities ...
关键词：HIV-1 RT Non-nucleoside reverse transcriptase inhibitors S-DABOs 
Computational modeling studies on anti-HIV-1 non-nucleoside reverse transcriptase inhibition by dihydroalkoxybenzyloxopyrimidines analogues: an electrotopological atomistic approach
《Journal of Biophysical Chemistry》2011年第3期361-372,共12页Nitin S. Sapre Tarang Bhati Swagata Gupta Nilanjana Pancholi Urmila Raghuvanshi Divya Dubey Vandana Rajopadhyay Neelima Sapre 
For the first time we report quantitative structure activity relationship (QSAR) studies based on Kier-Hall Electrotopological State (E-State) Indices for Dihydroalkoxybenzyloxopyrimidines (DABO) derivatives acting as...
关键词：AIDS HIV-1 NNRTIS DABOs QSAR pIC50 Kier Hall E-State Indices MLR NN K-NN 
Characterization of Genotypic Mutations and Antiretroviral Resistance among Viremic HIV-Infected Patients in a High HIV Prevalence Area: Treatment Challenge and Transmission Risk
《World Journal of AIDS》2011年第3期70-77,共8页AliAsad Arastu Virginia Kan 
There have been few reports evaluating the prevalence of genotypic mutations and antiretroviral resistance among chronic HIV-infected Veterans within the United States. This retrospective cross-sectional study charact...
关键词：HIV Viremia ANTIRETROVIRAL Resistance GENOTYPIC ANTIRETROVIRAL MUTATIONS Transmission Nucleoside/Nucleotide REVERSE Transcriptase INHIBITORS NON-NUCLEOSIDE REVERSE Transcriptase INHIBITORS Protease INHIBITORS 
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