ADEFOVIR

作品数：52被引量：392H指数：13
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相关领域：医药卫生更多>>
相关作者：沈中阳邓永林朱志军蔡金贞郑虹更多>>
相关机构：天津市第一中心医院北京地坛医院上海第二医科大学附属新华医院重庆医科大学附属第二医院更多>>
相关期刊：《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Hepatobiliary & Pancreatic Diseases International》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国肝炎防治基金更多>>
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Discuss the clinical observation of tenofovir ester and adefovir in the treatment of chronic hepatitis B
《外文科技期刊数据库(文摘版)医药卫生》2022年第2期163-166,共4页YAOZhenyu YANQinglin 
Objective: To examine the clinical efficacy and safety of tenofovir ester combined with adefovir in the treatment of chronic hepatitis B (CHB).Methods: The 130 patients with chronic hepatitis B admitted from January 2...
关键词：chronic hepatitis B tenofovir ester adefovir ester hepatitis B virus deoxyribonucleic acid 
Adefovir Dipivoxil plus Chinese Medicine in HBeAg-Positive Chronic Hepatitis B Patients:A Randomized Controlled 48-Week Trial被引量：12
《Chinese Journal of Integrative Medicine》2020年第5期330-338,共9页LI Xiao-ke ZHANG Ming-xiang SHAO Feng-zhen ZHOU Da-qiao XUE Jing-dong LIU Tie-jun CHI Xiao-ling LU Bing-jiu WANG Xian-bo LI Qin LI Jun MAO De-wen YANG Hua-sheng YANG Hong-zhi ZHAO Wen-xia LI Yong ZHANG Guo-liang ZHAO Yi-ming ZOU Jian-dong LIU Meng-yang ZHANG Ke-ke YANG Xian-zhao GAN Da-nan LI Ying ZHANG Peng LI Zhi-guo LI Shuo YE Yong-an 
Supported by the China National Science and Technology Major Projects,11th 5-year Project(No.2008ZX10005-006)。
Objective:To evaluate the effects of a 48-week course of adefovir dipivoxil(ADV)plus Chinese medicine(CM)therapy,namely Tiaogan Jianpi Hexue(调肝健脾和血)and Tiaogan Jiedu Huashi(调肝解毒化湿)fomulae,in hepatitis B e ...
关键词：ADEFOVIR dipivoxil Tiaogan Jianpi Hexue Tiaogan Jiedu Huashi Chinese medicine HBEAG combination therapy 
Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study被引量：18
《World Journal of Gastroenterology》2017年第41期7459-7469,共11页Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 
AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virolog...
关键词：TENOFOVIR Lamivudine+Adefovir EFFICACY Safety ADHERENCE COSTS Hepatitis B 
Predictors for Efficacy of Combination Therapy with a Nucleos(t)ide Analogue and Interferon for Chronic Hepatitis B被引量：2
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2017年第4期547-555,共9页李红 王华 彭程 郑昕 刘嘉 翁志宏 杨东亮 
supported by grants from National Science and Technology Major Project for Infectious Diseases of China(No.2013ZX10002001-001-006);the National Natural Science Foundation of China(No.81461130019);Deutsche Forschungsgemeinschaft(No.Transregio TRR60)
This study aims to explore the efficacy of interferon-α（IFN-α） combined with either entecavir（ETV） or adefovir（ADV） therapy versus IFN-α mono-therapy for chronic hepatitis B（CHB） patients, and to identify t...
关键词：chronic hepatitis B adefovir entecavir combination therapy interferon-α ROC analysis 
Adverse effects of oral antiviral therapy in chronic hepatitis B被引量：22
《World Journal of Hepatology》2017年第5期227-241,共15页Bircan Kayaaslan Rahmet Guner 
Oral nucleoside/nucleotide analogues(NAs) are currently the backbone of chronic hepatitis B(CHB) infection treatment. They are generally well-tolerated by patients and safe to use. To date, a significant number of pat...
关键词：Nucleoside/nucleotide analogues Adverse events LAMIVUDINE Chronic hepatitis B Side effects Safety TELBIVUDINE Hepatitis B infection ADEFOVIR ENTECAVIR Adverse effects TENOFOVIR Hepatitis B virus 
Observation on the effect of adefovir dipivoxil in combined with lamivudine in the treatment of hepatitis B cirrhosis
《Journal of Hainan Medical University》2017年第5期13-16,共4页Li Cui 
Objective:To explore the effect of adefovir dipivoxil in combined with lamivudine on the liver function in patients with hepatitis B cirrhosis and the antiviral efficacy.Methods:A total of 156 patients with hepatitis ...
关键词：HEPATITIS B CIRRHOSIS ADEFOVIR dipivoxil LAMIVUDINE Liver function ANTIVIRAL EFFICACY 
Management of entecavir-resistant chronic hepatitis B with adefovir-based combination therapies被引量：13
《World Journal of Gastroenterology》2015年第38期10874-10882,共9页Hyoung Su Kim Hyung Joon Yim Myoung Kuk Jang Ji Won Park Sang Jun Suh Yeon Seok Seo Ji Hoon Kim Bo Hyun Kim Sang Jong Park Sae Hwan Lee Sang Gyune Kim Young Seok Kim Jung Il Lee Jin-Woo Lee In Hee Kim Tae Yeob Kim Jin-Wook Kim Sook-Hyang Jeong Young Kul Jung Hana Park Seong Gyu Hwang 
Supported by Research Funds from the Korean Association for the Study of the Liver(in part)
AIM: To evaluate the long-term efficacy adefovir(ADV)-based combination therapies in entecavir(ETV)-resistant chronic hepatitis B(CHB) patients. METHODS: F i fty CHB pat ient s wi t h genotypic resistance to ETV at 13...
关键词：ADEFOVIR CHRONIC HEPATITIS B ENTECAVIR LAMIVUDINE 
Risk for hepatocellular carcinoma in the course of chronic hepatitis B virus infection and the protective effect of therapy with nucleos(t)ide analogues被引量：21
《World Journal of Hepatology》2015年第8期1064-1073,共10页Irene Rapti Stephanos Hadziyannis 
Hepatocellular carcinoma(HCC) is a major health problem worldwide, representing one of the leading causes of death. Chronic hepatitis B virus(HBV) infection(CHB) is the most important etiologic factor of this tumor, a...
关键词：Chronic hepatitis B Cirrhosis Hepatocellular carcinoma Hepatitis B virus Treatment Interferon LAMIVUDINE ADEFOVIR ENTECAVIR TENOFOVIR Virological remission Nucleos(t)ide analogues 
Liquid chromatography-tandem mass spectrometry method for the estimation of adefovir in human plasma:Application to a pharmacokinetic study
《Journal of Pharmaceutical Analysis》2015年第3期190-199,共10页Dipanjan Goswami Sanjay Gurule Arabinda Saha Poonam Vats Arshad Khuroo Tausif Monif 
support and facilities received from Ranbaxy Research Laboratories Gurgaon,India
An analytical method based on solid phase extraction was developed and validated for analysis of adefovir in human plasma. Adefovir-d4 was used as an internal standard and Synergi MAX RP80A （150rnmx4.6mm. 41am） colu...
关键词：Liquid chromatography-tandem massspectrometry Solid phase extraction Pharmacokinetic study 
Early kidney injury during long-term adefovir dipivoxil therapy for chronic hepatitis B被引量：22
《World Journal of Gastroenterology》2015年第12期3657-3662,共6页Hong-Yu Jia Feng Ding Jian-Yang Chen Jiang-Shan Lian Yi-Min Zhang Lin-Yan Zeng Dai-Rong Xiang Liang Yu Jian-Hua Hu Guo-Dong Yu Huan Cai Ying-Feng Lu Lin Zheng Lan-Juan Li Yi-Da Yang 
Supported by National Key Program for Infectious Diseases of China(to Yang YD),No.2013ZX10002001;12th FiveYear Significant New Drugs Creation Plan of the Ministry of Science and Technology of China(to Yang YD),No.2011ZX09302-003-03
AIM: To evaluate urine β2-microglobulin(β2-M), retinol-binding protein(RBP) excretion, and renal impairment with adefovir dipivoxil(ADV) for chronic hepatitis B. METHODS: We enrolled 165 patients with chronic hepati...
关键词：ADEFOVIR dipivoxil ENTECAVIR RETINOL BINDING prote 
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