SYNAPSIN

作品数:29被引量:110H指数:7
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40 Hz声光刺激对创伤诱发大鼠焦虑样行为的干预作用
《中国应用生理学杂志》2022年第5期418-423,共6页尹佳怡 杲修杰 张鑫垚 郑鹏芳 李小芳 王瑞 崔博 
山东省科技厅重点研发计划项目(2017GSF218042);军事科学院研究项目(JK20202A020453)。
目的:探讨40 Hz声光刺激对创伤后应激障碍(PTSD)的焦虑样症状改善作用及其可能的分子机制。方法:将30只SD大鼠随机分为Control组、PTSD组、PTSD+40 Hz组,每组10只。采用SPS&S方法构建PTSD模型。PTSD+40 Hz组大鼠在构建模型后,施加声光刺...
关键词:创伤后应激障碍(PTSD) 40 Hz声光刺激 BDNF TRKB PSD95 SynapsinⅠ 大鼠 
Research progress of the synapsin 2 gene polymorphism in the pathogenesis of schizophrenia
《Journal of Translational Neuroscience》2022年第1期1-5,共5页Zhilan Yang Hongying Pan Lan Jiang Yuhang Liang Jie Wu 
Yunnan Provincial Department of Science and Technology Project(202101AY070001-224).
Schizophrenia(SCZ)is the most common serious mental illness with a high disability rate and heavy social and family burdens.At present,there is no clear etiology and pathogenesis of schizophrenia.Studies have shown th...
关键词:schizophrenia(SCZ) hypothalamic-pituitary-adrenal(HPA)axis synapsin 2(SYN2) LIM-homeobox gene 3(Z/ZY3) early growth response 1(EGR1) 
Paired associated magnetic stimulation promotes neural repair in the rat middle cerebral artery occlusion model of stroke被引量:8
《Neural Regeneration Research》2020年第11期2047-2056,共10页Bei-Yao Gao Cheng-Cheng Sun Guo-Hua Xia Shao-Ting Zhou Ye Zhang Ye-Ran Mao Pei-Le Liu Ya Zheng Dan Zhao Xu-Tong Li Janie Xu Dong-Sheng Xu Yu-Long Bai 
supported by the National Natural Science Foundation of China,Nos.81974358,81772453(to DSX)。
Paired associative stimulation has been used in stroke patients as an innovative recovery treatment.However,the mechanisms underlying the therapeutic effectiveness of paired associative stimulation on neurological fun...
关键词:BRAIN-DERIVED NEUROTROPHIC factor finite element simulation glutamate receptor IPSILATERAL hemisphere paired associative STIMULATION PSD95 resting-state functional MRI STROKE SYNAPSIN I transcranial magnetic STIMULATION 
SIRT1调节突触蛋白Synapsin 1表达和神经元树突生长被引量:1
《中国生物化学与分子生物学报》2020年第11期1353-1358,共6页顾群 黄琴 徐子淇 吴凡 尹晓敏 张旭 钱慰 
国家自然科学基金(No.81872875,81473218,81170317);江苏省高校优势学科建设项目(PAPD);江苏省大学生创新训练计划项目(No.201910304105Y)资助。
阿尔茨海默病(Alzheimer’s disease,AD)早期就出现突触功能紊乱。沉默调节蛋白1(silent information regulator 1,SIRT1)是与AD相关的重要去乙酰化酶。本研究探讨了SIRT1对突触蛋白1(synapsin 1)表达和对神经元树突生长的影响。Wester...
关键词:阿尔茨海默病 沉默调节蛋白1 突触蛋白1 神经元树突 
大鼠神经病理性痛时脊髓mGluR4与SynapsinⅠ的关系
《中华麻醉学杂志》2020年第5期603-605,共3页陈锐 江伟 王华 
国家自然科学基金青年基金项目(81100825)。
目的评价大鼠神经病理性痛时脊髓代谢型谷氨酸受体4(mGluR4)与突触素Ⅰ(SynapsinⅠ)的关系。方法取鞘内置管成功的清洁级健康雄性SD大鼠40只,体重200~250 g,采用随机数字表法分为4组(n=10):对照组(Con组)、神经病理性痛组(NP组)、mGluR...
关键词:神经痛 受体 谷氨酸 突触素1 脊髓 
A novel pathway regulates social hierarchy via lncRNA AtLAS and postsynaptic synapsin Ⅱb被引量:6
《Cell Research》2020年第2期105-118,共14页Mei Ma Wan Xiong Fan Hu Man-Fei Deng Xian Huang Jian-Guo Chen Heng-Ye Man Youming Lu Dan Liu Ling-Qiang Zhu 
Supported partially by the National Natural Science Foundation of China(81871108,81829002,81961128005,81761138043,91632114,81771150,31571039,31721002),Top-Notch Young Talents Program of China of 2014,and Academic Frontier Youth Team of Huazhong University of Science and Technology to L.Q.Z.
Dominance hierarchy is a fundamental phenomenon in grouped animals and human beings,however,the underlying regulatory mechanisms remain elusive.Here,we report that an antisense long non-coding RNA(lncRNA)of synapsinⅡ...
关键词:expression. POSTSYNAPTIC AMPA 
Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury被引量:12
《Neural Regeneration Research》2018年第8期1417-1424,共8页Lin Zhu Tao Tang Rong Fan Jie-Kun Luo Han-Jin Cui Chun-Hu Zhang Wei-Jun Peng Peng Sun Xin-Gui Xiong Yang Wang 
supported by the National Natural Science Foundation of China,No.81673719,81173175 and 81303074;a grant from China Postdoctoral Science Foundation,No.2016M600639 and 2017T100614
Xuefu Zhuyu decoction has been used for treating traumatic brain injury and improving post-traumatic dysfunction, but its mechanism of action needs further investigation. This study established rat models of traumatic...
关键词:nerve regeneration traumatic brain injury Xuefu Zhuyu decoction neurological dysfunction SYNAPSIN SYNAPTOPHYSIN synapsin I POSTS vnaptic density protein-95 NEUROPROTECTION neural regeneration 
The Role of Synapsins in Neurological Disorders被引量:10
《Neuroscience Bulletin》2018年第2期349-358,共10页Fatima Javed Mirza Saadia Zahid 
Synapsins serve as flagships among the presynaptic proteins due to their abundance on synaptic vesicles and contribution to synaptic communication. Several studies have emphasized the importance of this multi-gene fam...
关键词:Synapsin  Synapsin  Synapsin  Neurological disorders 
Blocking beta 2-adrenergic receptor inhibits dendrite ramification in a mouse model of Alzheimer's disease被引量:4
《Neural Regeneration Research》2017年第9期1499-1506,共8页Qin Wu Jin-xia Sun Xiang-he Song Jing Wang Cun-quan Xiong Fei-xiang Teng Cui-xiang Gao 
supported by the Key Laboratory of Brain Disease Bioinformation of Jiangsu Province of China,No.Jsbl1202
Dendrite ramification affects synaptic strength and plays a crucial role in memory. Previous studies revealed a correlation between beta 2-adrenergic receptor dysfunction and Alzheimer's disease (AD), although the ...
关键词:nerve regeneration NEURODEGENERATION beta-2 adrenergic receptor Alzheimer's disease amyloid-β ICI 118551 cognitive function dendrite ramification synapsin 1 SYNAPTOPHYSIN a-secretase amyloid precursor protein neural regeneration 
新型Rho激酶抑制剂FSD-C10对A53T细胞突起的作用
《中国实用神经疾病杂志》2017年第11期1-4,共4页赵静 张伟 马杰 张海飞 尉杰忠 柴智 宋丽娟 肖保国 马存根 
国家自然科学基金2012年面上项目(81272163);山西省回国留学人员重点科研资助项目(2014-重点7);山西中医学院“2011”培育计划项目(2011PY-1)
目的探讨新型Rho激酶抑制剂FSD-C10对A53T细胞突起的影响及其促进突起生长的机制。方法 A53T细胞进行常规培养和传代,细胞生长到90%左右后,根据不同实验的需要,分为PBS阴性对照组、Fasudil阳性对照组及FSD-C10干预组。应用Image-Pro Plu...
关键词:FSD-C10 A53T细胞 突起 synapsinⅠ 
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