In order to diagnose a major depressive disorder, patients must have at least 5 depres-sive symptoms out of 9 criteria, present for at least two weeks. Depressive symptoms include absence of concentration, fatigue and...
Depression results from changes in the central nervous system(CNS) that may result from immunological abnormalities.The immune system affects the CNS through cytokines,which regulate brain activities and emotions.Cyto...
Recent literature based on peripheral immunity findings speculated that neuroinflammation,with its connection to microglial activation,is linked to bipolar disorder.The endorsement of the neuroinflammatory hypotheses ...
supported by the National Natural Science Foundation of China(30970942,91132306);the National Basic Research Development Program(973 program) of China (2010CB529605,2011CB504405);the "Hundred Talents Program" of the Chinese Academy of Sciences,the Guangdong Innovation Research Team Fund for Low-cost Healthcare Technologies;a Shenzhen Governmental Basic Research Grant
Inflammatory processes are an integral part of the stress response and are likely to result from a programmed adaptation that is vital to the organism's survival and well-being.The whole inflammatory response is medi...
Project partially supported by NIDA 47392;the State University of New York Research Foundation
Top down central nervous system (CNS) influences on the immune system and bottom up immune system influences on the CNS take part in a complex feedforward and feedback loop which may be responsible for initiating even...