financially supported by the National Natural Science Foundation of China(Nos.21877048,22077048 and 22277014);Guangxi Natural Science Foundation(Nos.2021GXNSFDA075003,AD21220061);the Startup Fund of Guangxi University(No.A3040051003)。
Owing to the anaerobic metabolism in the tumor,abundant acidic metabolites are produced and accumulated in the cells.Therefore,the cells in different tumor layers are directly linked to the pH micro-environment.Nevert...
supported by the National Natural Science Foundation of China(Nos.21776037,22174009);Dalian Sci-ence and Technology Innovation Fund(No.2020JJ25CY014);Quanzhou Science and Technology Plan Project(No.2019C033R).
To test the hypothesis that the microviscosity changes of Endoplasmic Reticulum(ER)can be a useful indicator of ferroptosis promoted by ER Stresses(ERS),a new ER targeting viscosity rotor,L-Vis-1 was developed and app...
supported by the National Natural Science Foundation of China (Nos.21421005,21576040,21776037,21901031 and 22078047);Science and Technology Foundation of Liaoning Province (No.2020-YQ-08);Dalian Science and Technology Innovation Fund (No.2020JJ25CY014);the Fundamental Research Funds for the Central Universities (Nos.DUT18RC(3)027 and DUT20RC(5)024)。
Here we propose a fluorescent sensor,Chroma-V,consisted of a Hoechst ligand(Hoe) to target chromatin DNA and a BODIPY rotor(BDP) to sense the local viscosity that reflects chromatin condensation state.Within Chroma-V,...