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BACKGROUND Anderson-Fabry disease(AFD)is an X-linked lysosomal storage disorder that results from a deficiency ofα-galactosidase A enzyme activity in which glycosphingolipids gradually accumulate in multi-organ syste...
Glycosylation is a common posttranslational modification on membrane-associated and secreted proteins that is of pivotal importance for regulating cell functions.Aberrant glycosylation can lead to uncontrolled cell pr...
The Ministry of Science and Technology of the People’s Republic of China[2016ZX09101017]supported this project.
Ganglioside and sulfatide are primary components of acidic glycosphingolipids(AGSLs),which are abundant in the brain tissue.AGSLs are potential tumor markers.In this paper,we use ultra-high performance liquid chromato...
the National Natural Science Foundation of China (31271517 and 31271518);State Key Laboratory of Molecular Developmental Biology;ZHYX (2017zhyx29) of Scientific Research Foundation of the Institute for Translational Medicine of Anhui Province;BSKY (XJ201123) of Anhui Medical University.
Glycosphingolipid (GSL) metabolism is involved in various physiological processes, including all major cell signaling pathways, and its dysregulation is linked to some diseases. The four-phosphate adaptor protein FAPP...
supported by JSPS KAKENHI from the Japan Society for the Promotion of Science and the Ministry of Education (15H05032 and 15K15752 to Takashi Nakamura and 26253092 to Satoshi Fukumoto)
Tooth crown morphogenesis is tightly regulated by the proliferation and differentiation of dental epithelial cells. Globoside (Gb4), a globo-series glycosphingolipid, is highly expressed during embryogenesis as well...
Fabry disease(FD)is a rare,progressive,multisystem and highly debilitating disease.FD is an X-linked lysosome storage disorder that results inα-galactosidase A deficiency.The subsequent accumulation of glycosphingoli...
This work was supported by the Finnish Funding Agency for Technology and Innovation(TEKES);the EVO Medical Research Fund of Finnish Red Cross Blood Service and The Finnish Glycoscience Graduate School.
Umbilical cord blood(UCB)is an efficient and valuable source of hematopoietic stem cells(HSCs)for transplantation.In addition to HSCs it harbours low amounts of mesenchymal stem cells(MSCs).No single marker to identif...
By using the Ladisch partitioning and microscale-analysis of HPTLC,the comparative quantitative and qualitative studies of gangliosides (Gg)and neutral glycosphingolipids(N-GSL)compositions from human chorionic villi ...