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Vitamin B_(12)-auxotrophy in dinoflagellates caused by incomplete or absent cobalamin-independent methionine synthase genes(metE): 《Fundamental Research》2022年第5期727-737,共11页Siheng Lin Zhangxi Hu Xiaoying Song Christopher JGobler Ying Zhong Tang; edge the financial support from the National Natural Science Foundation of China(Grant No.41776125);the Key Deployment Project of Centre for Ocean Mega-Research of Science,Chinese Academy of Sciences(Grant No.COMS2019Q09);the Science&Technology Basic Resources Investigation Program of China(Grant No.2018FY100200);National Natural Science Foundation of China(Grants Nos.41976134 and 61533011);the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(Qingdao)(Grant No.2018SDKJ0504-2);supported by the Chicago Community Trust.; Dinoflagellates are responsible for most marine harmful algal blooms (HABs) and play vital roles in many ocean processes.More than 90% of dinoflagellates are vitamin B_(12) auxotrophs and that B_(12) availability can ...; 关键词：Harmful algal blooms(HABs)Dinoflagellates Vitamin B_(12) (cobalamin) Auxotrophy Methionine synthase genes Phytoplankton ecology

Enhanced cobalamin biosynthesis in Ensifer adhaerens by regulation of key genes with gradient promoters被引量：1: 《Synthetic and Systems Biotechnology》2022年第3期941-948,共8页Sha Xu Zhiqiang Xiao Shiqin Yu Weizhu Zeng Yongming Zhu Jingwen Zhou; supported by the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(32021005);the National Science Fund for Excellent Young Scholars(21822806).; Cobalamin is an essential human vitamin widely used in the pharmaceutical,food,and feed additive industries and currently produced by bacteria or archaea.Ensifer adhaerens HY-1 is an industrial strain that also produc...; 关键词：Ensifer adhaerens COBALAMIN Genome sequence Transcriptome sequence PROMOTER OVEREXPRESSION COMBINATIONS

Cryo-EM structure of human lysosomal cobalamin exporter ABCD4被引量：3: 《Cell Research》2019年第12期1039-1041,共3页Da Xu Zhang Feng Wen-Tao Hou Yong-Liang Jiang Liang Wang Linfeng Sun Cong-Zhao Zhou Yuxing Chen; the Ministry of Science and Technology of China(2015CB910103);the Chinese Academy of Science(XDB08020304);the National Natural Science Foundation of China(31621002);the Fundamental Research Funds for the Central Universities(WK2070000117).; Dear Editor,Cobalamin,also known as vitamin B12,can only be biosynthesized by certain bacteria and archaea.As an essential nutrient for humans,it should be obtained from daily food.1 Exogenous cobalamin is taken up by...; 关键词：VITAMIN STRUCTURE finally

Manic-depressive Psychosis as the Initial Symptom in Adult Siblings with Late-onset Combined Methylmalonic Aciduria and Homocystinemia, Cobalamin C Type被引量：13: 《Chinese Medical Journal》2017年第4期492-494,共3页Li-Yong Wu Hong An Jia Liu Jie-Ying Li Yue Han Ai-Hong Zhou Fen Wang Jian-Ping Jia; Methylmalonic aciduria （MMA） is an autosomal recessive disorder of cobalamin （cbl） metabolism. Cobalamin C （cblC） disease is the most common type of MMA and is characteristically concurrent with homocystinemia ...; 关键词：Homocystinemia LATE-ONSET Manic-depressive Psychosis Methylmalonic Aciduria Methylmalonic Aciduria and Homocystinemia Type C Protein

Clinical characteristics of hemolytic uremic syndrome secondary to cobalamin C disorder in Chinese children被引量：3: 《World Journal of Pediatrics》2015年第3期276-280,共5页Qi-Liang Li Wen-Qi Song Xiao-Xia Peng Xiao-Rong Liu Le-Jian He Li-Bing Fu; supported by a grant from the Special Program for Clinical Research of the Beijing Municipal Commission of Science and Technology and WU JIE PING Medical Foundation,China(Grant Z121107005112008); Background:The present study was undertaken to investigate the clinical characteristics of hemolytic uremic syndrome(HUS)secondary to cobalamin C disorder(cbl-C disorder).Methods:We reviewed retrospectively the medica...; 关键词：CHILDREN cobalamin C disorder hemolytic uremic syndrome

Cobalamin deficiency as an extra intestinal manifestation of Helicobacter pylori infection: 《World Journal of Gastroenterology》2015年第11期3447-3448,共2页Emmanuel Andrès; We read with great interest the excellent review by Wong et al on extra intestinal manifestations of Helicobacter pylori(H.pylori) infection published in the journal.This is a well-documented and structured review.How...; 关键词：COBALAMIN DEFICIENCY HELICOBACTER PYLORI Food-coba

Dodecylamine Derivative of Hydroxocobalamin Acts as a Potent Inhibitor of Cobalamin-Dependent Methionine Synthase in Mammalian Cultured COS-7 Cells被引量：1: 《Food and Nutrition Sciences》2014年第14期1318-1325,共8页Tomohiro Bito Mariko Yasui Toshio Iwaki Yukinori Yabuta Tsuyoshi Ichiyanagi Ryoichi Yamaji Yoshihisa Nakano Hiroshi Inui Fumio Watanabe; We evaluated whether the dodecylamine derivative of hydroxocobalamin acts as a potent inhibitor of cobalamin-dependent enzymes in an African green monkey kidney cell, COS-7. When the dodecylamine derivative (1.0 μmol...; 关键词：DODECYLAMINE DERIVATIVE COBALAMIN COS-7 Cell Enzyme Inhibitor Hydroxocobalamin

Determination of Vitamin B<sub>12</sub>in Chinese Black Tea Leaves被引量：1: 《Food and Nutrition Sciences》2014年第14期1326-1332,共7页Fei Teng Tomohiro Bito Shigeo Takenaka Yukinori Yabuta Fumio Watanabe; We determined vitamin B12 content of Chinese black tea leaves using a microbiological assay based on Lactobacillus delbrueckii ATCC 7830. Trace levels (0.25 - 0.69 μg/100g dry weight) of vitamin B12 were detected in...; 关键词：CHINESE Black TEA LEAVES COBALAMIN Ryubao TEA Vitamin B12

Saporin Conjugated Monoclonal Antibody to the Transcobalamin Receptor TCblR/CD320 Is Effective in Targeting and Destroying Cancer Cells被引量：1: 《Journal of Cancer Therapy》2013年第6期1074-1081,共8页Edward V. Quadros Yasumi Nakayama Jeffrey M. Sequeira; Cobalamin uptake into cells is mediated by the CD320 receptor for transcobalamin-bound cobalamin. Optimum receptor expression is associated with proliferating cells and therefore, in many cancers this receptor express...; 关键词：Transcobalamin RECEPTOR CD320 Gene COBALAMIN Cancer TOXIN

Association of comorbidities with increasing severity of peripheral neuropathy in diabetes mellitus被引量：7: 《World Journal of Diabetes》2013年第4期135-144,共10页Shafna Sachedina Cory Toth; AIM: To analyze a large population of patients with diabetes and peripheral neuropathy(PN) to determine other meaningful comorbid etiologies for PN.METHODS: Peripheral Neuropathy is a common complication of type 1 and...; 关键词：DIABETIC peripheral NEUROPATHY COMORBIDITIES Lipidemia COBALAMIN Methylmalonic acid

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