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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease
《Neural Regeneration Research》2025年第7期1981-1988,共8页Shan Ping Yu Emily Choi Michael QJiang Ling Wei 
supported by National Health Institute(NIH)grant NS099596(to LW and SPY),NS114221(to LW and SPY);Veterans Affair(VA)SPiRE grant RX003865(to SPY);supported by the O.Wayne Rollins Endowment Fund(to SPY);John E.Steinhaus Endowment Fund(to LW)。
Stroke and Alzheimer's disease are common neurological disorders and often occur in the same individuals.The comorbidity of the two neurological disorders represents a grave health threat to older populations.This rev...
关键词：Ca^(2+)hypothesis cognitive deficits HYPERACTIVITY late-onset Alzheimer's disease NEURODEGENERATION N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment 
Sensitivity of miRNA-181a,miRNA-23b and miRNA-16 in the Late-Onset Neonatal Sepsis:A Diagnostic Study
《Maternal-Fetal Medicine》2024年第4期243-248,共6页Divya Katta Kopula Satyamoorthy Sridharan Uma Maheswari Balakrishnan Prakash Amboiram Kennedy Kumar 
University Grants Commission Rajiv Gandhi National Fellowship.
Objective: To evaluate the expression and diagnostic value of levels of the microRNAs(miRNAs),miRNA-181a,miRNA-23b,and miRNA-16,in late-onset neonatal sepsis(LOS)and compare them with the diagnostic utility of C-react...
关键词：MICRORNAS Real-time PCR Blood culture Biomarkers Late-onset sepsis 
Corrigendum:Sorl1 knockout inhibits expression of brain-derived neurotrophic factor:involvement in the development of late-onset Alzheimer’s disease
《Neural Regeneration Research》2024年第10期2211-2211,共1页
https://doi.org/10.4103/1673-5374.393108 In the article titled“Sorl1 knockout inhibits expression of brain-derived neurotrophic factor:involvement in the development of late-onset Alzheimer’s disease”,published on ...
关键词：INVOLVEMENT ALZHEIMER 
Late-onset Very long-chain acyl-CoA dehydrogenase deficiency diagnosis complicated by fulminant myocarditis in adult patient
《Journal of Intensive Medicine》2024年第3期400-402,共3页Martin Gérard Clair Douillard Julien Poissy Mehdi Marzouk Christophe Vinsonneau 
Introduction A 21-year-old woman presented to the emergency department with fatigue,abdominal pain and diarrhea.Her physical activity in school was strictly normal.She had no family medical history and no personal his...
关键词：DIAGNOSIS patient ELEVATED 
Associations between blood glucose and early- and late-onset colorectal cancer: evidence from two prospective cohorts and Mendelian randomization analyses
《Journal of the National Cancer Center》2024年第3期241-248,共8页Chenyu Luo Jiahui Luo Yuhan Zhang Bin Lu Na Li Yueyang Zhou Shuohua Chen Shouling Wu Qingsong Zhang Min Dai Hongda Chen 
funded by the Chinese Academy of Medical Science Innovation Fund for Medical Science(grant number:2022-I2M-1-0031);the National Natural Science Foundation of China(grant number:82173606);supported by the Beijing Nova Program of Science and Technology(grant number:20230484397);the Na-tional Natural Science Foundation of China(grant number:82273726).
Background: The incidence of early-onset colorectal cancer (EOCRC), which exhibits differential clinical, patho- logical, and molecular features compared to late-onset CRC (LOCRC), is rising globally. The potential di...
关键词：Colorectal cancer Early-onset colorectal cancer GLUCOSE Mendelian randomization Cancer prevention 
Comprehensive genomic analysis of early and late-onset hepatocellular carcinoma
《Genes & Diseases》2024年第4期77-81,共5页Jialin Yang Chao Chen Song Wang Yaru Zhang Jiaohui Pang Yajun Wang Qiuxiang Ou Hao Jiang Juying Liu 
approved by the Medical Ethics Committee of Nanjing Geneseeq Medical Laboratory(NSJB-MEC-2023-02).
Hepatocellular carcinoma(HCC)is the major histologic type of primary liver cancer,accounting for approximately 75%of liver cancer cases.'Despite many advancements in its treatment,the prognosis and drug response of HC...
关键词：patients PROGNOSIS CANCER 
Beyond the Rex: an innovative meso-intrahepatic portal vein bypass for late-onset extrahepatic portal vein occlusion after living donor liver transplantation被引量：1
《Hepatobiliary Surgery and Nutrition》2024年第4期662-668,共7页Chee-Chien Yong Hsu-Ting Yen Yu-Fan Cheng Leona Bettina Dungca Raymond Joseph De Vera Itsuko Chih-Yi Chen Chao-Long Chen 
The Meso-Rex bypass(MRB)is recognized as an effective treatment for portal hypertension secondary to extrahepatic portal vein occlusion(EHPVO)both in the pediatric and adult population,within or outside the context of...
关键词：Meso-Rex bypass(MRB) portal vein occlusion liver transplantation(LT) 
Sorl1 knockout inhibits expression of brain-derived neurotrophic factor:involvement in the development of late-onset Alzheimer's disease被引量：3
《Neural Regeneration Research》2024年第7期1602-1607,共6页Mingri Zhao Xun Chen Jiangfeng Liu Yanjin Feng Chen Wang Ting Xu Wanxi Liu Xionghao Liu Mujun Liu Deren Hou 
supported by the Community Development Office of Hunan Provincial Science and Technology Department;China,Nos.2020SK53613(to DH),21JJ31006(to DH);the Fundamental Research Funds of Central South University,Nos.CX20220375(to TX),2023zzts215(to MZ)。
Sortilin-related receptor 1(SORL1)is a critical gene associated with late-onset Alzheimer’s disease.SORL1 contributes to the development and progression of this neurodegenerative condition by affecting the transport ...
关键词：brain-derived neurotrophic factor late-onset Alzheimer’s disease N-methyl-D-aspartate receptor sortilin-related receptor 1 SYNAPSE 
E674Q(Shanghai APP mutant),a novel amyloid precursor protein mutation,in familial late-onset Alzheimer's disease被引量：2
《Genes & Diseases》2024年第2期1022-1034,共13页Yongfang Zhang Xinyi Xie Boyu Chen Lina Pan Jianping Li Wanbing Wang Jintao Wang Ran Tang Qiang Huang Xiaofen Chen Rujing Ren Zhentao Zhang Wei Fu Gang Wang 
supported by grants from the Ministry of Science and Technology of the People's Republic of China(No.2021ZD020180);the Natural Science Foundation of China(No.81971068,81922021,81773635,82073765).
Identified as the pathogenic genes of Alzheimer's disease(AD),APP,PSEN1,and PSEN2 mainly lead to early-onset AD,whose course is more aggressive,and atypical symptoms are more common than sporadic AD.Here,a novel misse...
关键词：Alzheimer's disease Amyloid beta APP mutation E674Q Late onset 
Late-onset Cholestasis with Paucity of Portal Area Secondary
《Journal of Clinical and Translational Hepatology》2024年第3期327-331,共5页Xuemei Zhang Kun Liu Xiaona Lu Wenlan Zheng Jia Shi Shihan Yu Hai Feng Zhuo Yu 
supported by National Natural Science Foun-dation of China(Nos.82222074,82074154,81774240);Siming Scholar from Shanghai Shuguang Hospital(No.SGXZ-201904);Shuguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission,Youth Tip-top Talent Program,Constant-emi-nent Program in Shanghai,Xinglin Youth Scholar Program from Shanghai University of Traditional Chinese Medicine.
Hepatocyte nuclear factor 1β(HNF1β)is essential for biliary development,while its genetic defect triggers the dysplasia of interlobular bile ducts,leading to life-threatening hepatitis and cholestasis.To date,this d...
关键词：HNF1β CHOLESTASIS Adult patient Paucity of the portal area Renal cysts Case report 
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