This work was supported by an award from the Department of Science and Technology of Jilin Province(20210402043GH and 20210204063YY).
Panax ginseng C.A.Mey.is an important plant species used in traditional Chinese medicine,whose primary active ingredient is a ginsenoside.Ginsenoside biosynthesis is not only regulated by transcription factors but als...
supported by the National Research Foundation of Korea,Republic of Korea(grant number 2022R1I1A1A01069773,2022R1F1A1063434,and 2022R1I1A1A01055913);the Technology Innovation Program,the Ministry of Trade,Industry&Energy,Republic of Korea(grant number 20009663);the OTTOGI Corporation,Republic of Korea,through the Research and Publication Project.
High hydrostatic pressure is a non-thermal processing technique for extracting functional compounds from herbal plants.This study aims to investigate the effectiveness of the combination of high hydrostatic pressure(H...
Background:Previous studies showed that New Zealand-grown ginseng contains an abundance of ginsenosides and that rare less polar ginsenosides,such as Rg3,exhibit more pharmacological activities than polar ginsenosides...
Panax genus belonging to a family of Araliaceae grow in Asia(9 species)and in North America(2 species).Especially Panax ginseng was listed in Chinese medical book,Shennong's Classic of Materia Medica approximately 2 t...
the National Natural Science Foundation of China(Grant No.81872996);the State Key Research and Development Project(Grant No.2017YFC1702104);the State Key Project for the Creation of Major New Drugs(2018ZX09711001-009-010);the Tianjin Municipal Education Commission Research Project(Grant No.2017ZD07)。
Inherent complexity of plant metabolites necessitates the use of multi-dimensional information to accomplish comprehensive profiling and confirmative identification.A dimension-enhanced strategy,by offline two-dimensi...
the grants from the National Natural Science Foundation of China (Nos.81673544 and 81874332);the Fundamental Research Fund of Central South University (No. 2016zzts584);the Teacher-student Innovation and Entrepreneurship Project of Central South University (No.2017gczd028);the Natural Science Foundation of Hunan Province of China (No.2016JJ4113);the Innovation Project for University Students of Hunan Province of China (No.774);the Natural Science Fund for Young Scholars of Xiangya Hospital of Central South University (No.2014Q06).
Cytochromes P450 (CYP450s),a superfamily of mono-oxygenases,are essential to generate highly functionalized secondary metabolites in plants and contribute to the diversification of specialized triterpenoid biosynthesi...
financially supported by Tianjin Municipal Education Commission Research Project(No.2017ZD07)
Shenshao Tablet(SST),prepared from Paeoniae Radix Alba(PRA)and total ginsenoside of Ginseng Stems and Leaves(GSL),is a traditional Chinese medicine(TCM)preparation prescribed to treat coronary heart disease.However,it...
supported by the National Natural Science Foundation of China(Nos.81303246,81703732);Projects of Priority-Discipline for Colleges and Universities of Jiangsu Province(integration of traditional Chinese and western medicine)
Given the limited studies and conflicting findings, the transport character of ginsenosides crossing the blood-brain barrier (BBB) remains unclear. The present study was designed to qualitatively determine the distr...
supported by the National Natural Science Foundation of China(No.81573789)
Ginsenoside Rh2(Rh2)is one of the major bioactive ginsenosides in Panax ginseng.However,the oral bioavailability of Rh2 is low,with P-glycoprotein(P-gp)and CYP3A4 being reported to be the main factors.The purpose of t...
Objective:To investigate the effect of total ginsenoside of ginseng stems and leaves (TGSL) on the pharmacokinetics of aspirin in rats.Methods:Sprague-Dawley rats were randomly divided into two groups (n =6),a combine...