Background: The 2020 consensus guidelines recommend AUC guided dosing as the preferred monitoring method for vancomycin. AUC based dosing has shown to reduce incidence of acute kidney injury (AKI), utilize lower daily...
National Natural Science Foundation of China,No.81874325;Key Innovative Team of Shanghai Top-Level University Capacity Building in Clinical Pharmacy and Regulatory Science at Shanghai Medical College,Fudan University,No.HJW-R-2019-66-19;Science and Technology Commission of Shanghai Municipality,No.18DZ1910604,No.19DZ1910703 and No.19XD1400900.
BACKGROUND Vancomycin is often used as an anti-infective drug in patients receiving antitumor chemotherapy.There are concerns about its adverse drug reactions during treatment,such as nephrotoxicity,ototoxicity,hypers...
supported by the Department of Science and Technology of Jiangxi Province(20161BBG70181);the Department of Health Science and Technology project of Jiangxi Province(20151022);the National Natural Science Foundation of China(81660620);Innovation and Entrepreneurship Training Program for College Students(20190402367).
To investigate the clinical application of vancomycin blood concentration monitoring in critically ill patients and the influence of the ABCB1 gene polymorphism on vancomycin dnug concentrations to guide clinically ra...
Background: Due to the relatively high renal toxicity of vancomycin injection (VCM), setting an initial dose that achieves a trough that ranges between 10 and 20 μg/mL on day 3 is important to ensure safety and minim...
supported by the operating grant of the Collaborative Health Research Project,Natural Sciences and Engineering Research Council of Canada,and Canadian Institute of Health Research(CHRPJ 385967).
A highly sensitive ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed for the quantification of vancomycin (VAN) in low volumes of rabbit serum. For each analysis,...
The public health problem created by multidrug resistant bacteria in the 21st century continues to receive attention by researchers all over the world. As the production of new antibiotics is not commeasurable with th...
Background: Extensively drug resistant Acinetobacter baumannii (XDR-AB) presents an increasing challenge to health care in Egypt as they are among the most common bacteria isolated in hospital setting. Treatment of su...
A new, simple, and one-step tool for the direct detection of vancomycin-resistant Enterocococcus (VRE) EPI-V®(Pilots Point LLC, Sarasota, FL) is presented. It contains all the ingredients in a unique stable powder...
Sepsis is a host’s response to an intravascular infection;however, in most patients the disease recurs after a seemingly effective treatment. The reappearance of bacteria in the systemic circulation has been attribut...
The first described vancomycin resistant enterococci (VRE) was about twenty years ago. Recently VRE have been reported by many clinics. However endocarditis due to VRE is still a rare entity and there are only a few c...