WHOLE-CELL

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Activation of zona incerta gamma-aminobutyric acid-ergic neurons alleviates depression-like and anxiety-like behaviors induced by chronic restraint stress
《World Journal of Psychiatry》2025年第2期209-221,共13页Si-Hai Chen Bo Lan Ying-Ying Zhang Guo-Hui Li Yu-Long Qian Ming-Xing Hu Yin-Lin Tian Wei-Dong Zang Jing Cao Guang-Hai Wang Yi-Gang Wang 
Supported by the Natural Science Foundation of Xiaogan,China,No.XGKJ2023010036.
BACKGROUND Depression is a prevalent affective disorder,but its pathophysiology remains unclear.Dysfunction in the gamma-aminobutyric acid(GABA)-ergic system may contribute to its onset.Recently,antidepressants(e.g.,b...
关键词：Zona incerta Gamma-aminobutyric acid-ergic DEPRESSION ANXIETY Animal behavior studies Whole-cell patchclamp 
NIR-Ⅱ-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition
《Acta Pharmaceutica Sinica B》2025年第2期1159-1170,共12页Yijian Gao Yachao Zhang Yujie Ma Xiliang Li Yu Wang Huan Chen Yingpeng Wan Zhongming Huang Weimin Liu Pengfei Wang Lidai Wang Chun-Sing Lee Shengliang Li 
upported by the National Natural Science Foundation of China(No.52173135);the Natural Science Foundation of Jiangsu Province(No.BK20231523,China);Jiangsu Specially Appointed Professorship,Leading Talents of Innovation and Entrepreneurship of Gusu(ZXL2022496,China);and the Suzhou Science and Technology Program(SKY2022039,China);Chun-Sing Lee thanks the support of the Research Grants Council of Hong Kong Special Administrative Region,General Research Fund(No.CityU 11300320,11318322,China);Prof.Lidai Wang acknowledges support from the National Natural Science Foundation of China(No.81627805);the Research Grants Council of the Hong Kong Special Administrative Region(21205016,11215817,11101618,China).
High-performance phototheranostics with combined photothermal therapy and photoacoustic imaging have been considered promising approaches for efficient cancer diagnosis and treatment.However,developing phototheranosti...
关键词：NIR-Ⅱ Semiconducting oligomer Photothermal therapy VACCINE Nanoparticles THERANOSTICS Breast carcinoma Immunotherapy 
Aberration correction for deformable-mirror-based remote focusing enables high-accuracy whole-cell super-resolution imaging
《Photonics Research》2024年第4期821-832,共12页WEI SHI YINGCHUAN HE JIANLIN WANG LULU ZHOU JIANWEI CHEN LIWEI ZHOU ZEYU XI ZHEN WANG KE FANG YIMING LI 
National Natural Science Foundation of China(62375116);Shenzhen Medical Research Fund(B2302038);Key Technology Research and Development Program of Shandong(2021CXGC010212);Science,Technology and Innovation Commission of Shenzhen Municipality(JCYJ20220818100416036,KQTD20200820113012029);Startup Grant from Southern University of Science and Technology。
Single-molecule localization microscopy(SMLM)enables three-dimensional(3D)investigation of nanoscale structures in biological samples,offering unique insights into their organization.However,traditional 3D super-resol...
关键词：enable MIRROR RESOLUTION 
Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function被引量：6
《Neural Regeneration Research》2022年第10期2253-2259,共7页Min-Yi Wu Wen-Jun Zou Pei Yu Yuhua Yang Shao-Jian Li Qiang Liu Jiatian Xie Si-Qi Chen Wei-Jye Lin Yamei Tang 
supported by the National Natural Science Foundation of China,Nos.81925031(to YT),81820108026(to YT),81972967(to WJL),81872549(to YL);the Youth Program of National Natural Science Foundation of China,No.81801229(to YTX);a grant from Guangdong Science and Technology Department of China,Nos.2020B1212060018(to WJL),2020B1212030004(to WJL);the Natural Science Foundation of Guangdong Province,No.2019A1515011754(to WJL);the Science and Technology Program of Guangzhou of China,No.202007030001(to YT);the Science and Technology Planning Project of Guangzhou of China,No.201704030033(to YL).
Radiation therapy is a standard treatment for head and neck tumors.However,patients often exhibit cognitive impairments following radiation therapy.Previous studies have revealed that hippocampal dysfunction,specifica...
关键词：GABA-mediated hyperfunction GluR intrinsic excitability long-term potentiation radiation-induced cognitive impairment spontaneous excitatory postsynaptic currents spontaneous inhibitory postsynaptic currents synaptic plasticity type I vesicular glutamate transporter vesicular GABA transporter whole-cell patch clamp recording 
Pathological Networks Involving Dysmorphic Neurons in Type ⅡFocal Cortical Dysplasia被引量：2
《Neuroscience Bulletin》2022年第9期1007-1024,共18页Yijie Shao Qianqian Ge Jiachao Yang Mi Wang Yu Zhou Jin-Xin Guo Mengyue Zhu Jiachen Shi Yiqi Hu Li Shen Zhong Chen Xiao-Ming Li Jun-Ming Zhu Jianmin Zhang Shumin Duan Jiadong Chen 
supported by grants from the Ministry of Science and Technology(2019YFA0110103);the National Natural Science Foundation of China(81870898,82071287,and 81870916);the Fundamental Research Funds for the Central Universities(2019FZA7009 and 2021FZZX001-37);the Zhejiang Provincial Natural Science Foundation(LR18H090002).
Focal cortical dysplasia(FCD)is one of the most common causes of drug-resistant epilepsy.Dysmorphic neurons are the major histopathological feature of typeⅡFCD,but their role in seizure genesis in FCD is unclear.Here...
关键词：Focal cortical dysplasia Dysmorphic neuron Whole-cell patch-clamp recording Morphological reconstruction Excitation-inhibition balance 
MicroRNA is a potential target for therapies to improve the physiological function of skeletal muscle after trauma被引量：1
《Neural Regeneration Research》2022年第7期1617-1622,共6页Xin-Yi Gu Bo Jin Zhi-Dan Qi Xiao-Feng Yin 
supported by the National Natural Science Foundation of China,Nos.82072162,81971177;Beijing Municipal Natural Science Foundation of China,No.7192215(all to XFY)。
MicroRNAs can regulate the function of ion channels in many organs.Based on our previous study we propose that miR-142a-39,which is highly expressed in denervated skeletal muscle,might affect cell excitability through...
关键词：C2C12 DENERVATION ion channels MICRORNA miR-142a-3p muscle patch clamp potassium sodium whole-cell currents 
A novel inactivated whole-cell Pseudomonas aeruginosa vaccine that acts through the cGAS-STING pathway被引量：3
《Signal Transduction and Targeted Therapy》2021年第11期3256-3269,共14页Cuicui Ma Xiao Ma Boguang Jiang Hailong Pan Xueyuan Liao Li Zhang Wenfang Li Yingjie Luo Zhixue Shen Xingjun Cheng Mao Lian Zhenling Wang 
This study was supported by the Chinese Major Scientific and Technological Special Project for“Significant New Drugs Creation”,National Key Project(2019ZX09721-001-004-004);Key Technologies and Transformation Platform for Rapid Emergency Vaccine R&D for“the Sichuan Province Key R&D Program”(2020YFS0568).
Pseudomonas aeruginosa infection continues to be a major threat to global public health,and new safe and efficacious vaccines are needed for prevention of infections caused by P.aeruginosa.X-ray irradiation has been u...
关键词：VACCINE prevention utilized 
Expression and effect of sodium-potassium-chloride cotransporter on dorsal root ganglion neurons in a rat model of chronic constriction injury被引量：2
《Neural Regeneration Research》2020年第5期912-921,共10页Chao-Yang Tan Yan-Ping Wang Yuan-Yuan Han Bi-Han Lu Wei Ji Li-Cang Zhu Yang Wang Wen-Yan Shi Li-Ya Shan Liang Zhang Ke-Tao Ma Li Li Jun-Qiang Si 
supported by the National Natural Science Foundation of China,No.30160026(to JQS);the High Level Talent Research Project of Shihezi University of China,No.RCSX201705(to YW)
Sodium-potassium-chloride cotransporter 1 (NKCC1) and potassium-chloride cotransporter 2 (KCC2) are associated with the transmission of peripheral pain.We investigated whether the increase of NKCC1 and KCC2 is associa...
关键词：BUMETANIDE chronic constriction injury DORSAL ROOT ganglion DORSAL ROOT reflex hyperalgesia KCC2 nerve regeneration NEUROPATHIC pain NKCC1 primary afferent depolarization WHOLE-CELL patch clamp 
Identification and characterization of a series of novel HCN channel inhibitors被引量：1
《Acta Pharmacologica Sinica》2019年第6期746-754,共9页Shu-jun Chen Yao Xu Ye-mei Liang Ying Cao Jin-yan Lv Jian-xin Pang Ping-zheng Zhou 
National Natural Science Foundation of China 81503042;Pearl River Nova Program of Guangzhou 201605111735229 (to PZ).
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play a critical role in controlling pacemaker activity in both heart and nervous system. Developing HCN channel inhibitors has been proposed to be an ...
关键词：HCN channel WHOLE-CELL PATCH CLAMP PAIN heart failure STRUCTURE-ACTIVITY relationship 
Effects of Lizhong Tang on cultured mouse small intestine interstitial cells of Cajal被引量：2
《World Journal of Gastroenterology》2013年第14期2249-2255,共7页Min Woo Hwang Jung Nam Kim Ho Jun Song Bora Lim Young Kyu Kwon Byung Joo Kim 
Supported by The Traditonal Korean Medicine R and D Project,Ministry of Health and Welfare,South Korea,No.B120008
AIM:To investigate the effects of Lizhong Tang,an herbal product used in traditional Chinese medicine,on mouse small intestine interstitial cells of Cajal(ICCs).METHODS:Enzymatic digestions were used to dissociate ICC...
关键词：INTERSTITIAL cells of CAJAL Lizhong TANG MOTILITY Gastrointestinal TRACT WHOLE-CELL patch clamp configuration 
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