PRIME-BOOST

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相关作者：刘颖孙铭飞宋爽王艳秋高旭更多>>
相关机构：中国疾病预防控制中心延边大学吉林大学河北医科大学更多>>
相关期刊：《Cellular & Molecular Immunology》《Science China(Life Sciences)》《中国现代普通外科进展》《Virologica Sinica》更多>>
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基于Prime-Boost免疫策略的猪附红细胞体eno基因免疫效果评价被引量：1
《中国动物传染病学报》2022年第3期88-92,共5页李明宣 董亮 相思宇 闫可心 许应天 薛书江 
国家自然科学基金(31460657);吉林省教育厅“十三五”科学技术项目(JJKH20191134KJ)。
为了评估猪附红细胞体eno基因核酸疫苗与重组腺病毒疫苗采用Prime-Boost免疫策略对小鼠的免疫效果,本研究应用pVAX1-eno核酸疫苗和Ad5-M/eno重组腺病毒疫苗免疫接种小鼠,将20只BALB/c小鼠随机分为4组:Prime-Boost策略组、Ad5-M/eno重组...
关键词：猪附红细胞体 eno基因 Prime-Boost策略 免疫水平 
Heterologous prime-boost with AdC68- and mRNA-based COVID-19 vaccines elicit potent immune responses in mice被引量：1
《Signal Transduction and Targeted Therapy》2022年第1期25-27,共3页Wenjuan Li Xingxing Li Danhua Zhao Jingjinq Liu Ling Wang Miao Li Xinyu Liu Jia Li Xiaohong Wu Yuhua Li 
Dear Editor An optimal vaccination program that can elicit Iong-lasting humoral and cellular immune response is key to Iong-term prevention of coronavirus disease 2019(COVID-19).Multiple variants of severe acute respi...
关键词：vaccines PREVENTION ACUTE 
Cyclophosphamide loaded thermo-responsive hydrogel system synergize with a hydrogel cancer vaccine to amplify cancer immunotherapy in a prime-boost manner被引量：4
《Bioactive Materials》2021年第10期3036-3048,共13页Fan Yang Kun Shi Ying Hao Yanpeng Jia Qingya Liu Yu Chen Meng Pan Liping Yuan Yongyang Yu Zhiyong Qian 
This work was financially supported by the National Natural Science Foundation of China(31930067,31525009,31800797 and 31771096);the National Key Research and Development Program of China(2017YFC1103502);China Postdoctoral Science Foundation(2018M631094 and 2019M653410);1⋅3⋅5project for disciplines of excellence,West China Hospital,Sichuan University(ZYGD18002).
Although neoantigen-based cancer vaccines show great potential in cancer immunotherapy due to their ability to induce effective and long-lasting anti-tumor immunity,their development is hindered by the limitations of ...
关键词：IMMUNOTHERAPY Thermo-responsive hydrogels Immunogenic cell death Cancer vaccine CYCLOPHOSPHAMIDE 
Efficient control of chronic LCMV infection by a CD4 T cell epitope-based heterologous prime-boost vaccination in a murine model被引量：1
《Cellular & Molecular Immunology》2018年第9期815-826,共12页Ran He Xinxin Yang Cheng Liu Xiangyu Chen Lin Wang Minglu Xiao Jianqiang Ye Yuzhang Wu Lilin Ye 
The work was supported by National Basic Research Program of China(973 program,2013CB531500,to LY);the National Natural Science Foundation of China(81471624 to LY).
CD4^(+)T cells are essential for sustaining CD8^(+)T cell responses during a chronic infection.The adoptive transfer of virus-specific CD4^(+)T cells has been shown to efficiently rescue exhausted CD8^(+)T cells.Howev...
关键词：CD4^(+)T cell epitope CD8^(+)T cell exhaustion chronic viral infection PRIME-BOOST 
The Mycobacterium bovis BCG prime-Rv0577 DNA boost vaccination induces a durable Thl immune response in mice被引量：2
《Acta Biochimica et Biophysica Sinica》2016年第4期385-390,共6页Dongqing Gu Wei Chen Youjun Mi Xueli Gong Tao Luo Lang Bao 
Tuberculosis remains a major global health problem and effective vaccines are urgently needed. In this study, we used the combined DNA- and protein-based vaccines of immunodominant antigen Rv0577 to boost BCG and eval...
关键词：Mycobacterium tuberculosis prime-boost strategy Rv0577 BCG DNA vaccine 
Prime-boost免疫策略在抗顶复门原虫感染中的应用被引量：2
《畜牧与兽医》2015年第1期130-134,共5页陈海宁 戚南山 廖申权 吴彩艳 李娟 吕敏娜 仝宗喜 孙铭飞 
国家自然科学基金(31201902;31302086;31402186);珠江科技新星项目(2012J2200059);广东省农业攻关项目(2012A020100001);广州市产学研合作专项(2014Y2-00003)
顶复门原虫对人类健康以及畜牧业生产危害严重,其入侵会激发机体的抵御机制,引起机体促炎反应,进而给机体造成伤害。使用基因工程疫苗可增强机体的体液免疫和细胞免疫,从而阻止虫体入侵。在抗寄生虫感染过程中,免疫策略的选择至关重要,...
关键词：顶复门原虫 PRIME-BOOST 寄生虫感染 免疫反应 
PEI增强G250 DNA疫苗和重组肽疫苗的prime-boost免疫策略研究
《中国现代普通外科进展》2014年第11期862-866,共5页孙泽强 孙发海 阮喜云 李青 杨广笑 王全颖 郭忠义 刘庆勇 
目的 :探讨PEI作为免疫佐剂对G250抗原肽基因PVAX1/C-G250肽-C免疫保护效果的增强作用及联合应用CAIX蛋白疫苗进行PRIME—BOOST免疫程序免疫增强效果。方法:用Eco R I、Xho I和Eco R I、Sal I分别双酶切PVAX1及既往构建的p ET28a(+)/C-G...
关键词：DNA疫苗 G250 PEI 佐剂 PRIME-BOOST 
Immunogenicity analysis following human immunodeficiency virus recombinant DNA and recombinant vaccinia virus Tian Tan prime-boost immunization被引量：7
《Science China(Life Sciences)》2013年第6期531-540,共10页LIU CunXia DU ShouWen LI Chang WANG YuHang WANG MaoPeng LI Yi YIN RongLan LI Xiao REN DaYong QIN YanQing REN JingQiang JIN NingYi 
supported by the National Natural Science Foundation of China (81001342);the National Basic Research Program of China (2011CB512110);the National Mega Project on Major Infectious Diseases Prevention (2012ZX10001005-006)
This study assessed and compared the immunogenicity of various immunization strategies in mice using combinations of re- combinant DNA （pCCMp24） and recombinant attenuated vaccinia virus Tian Tan （rddVTT_ccMpe4）. ...
关键词：vaccinia virus Tian Tan human immunodeficiency virus recombinant DNA PRIME-BOOST IMMUNOGENICITY 
HIV复合表位DNA重组体和痘苗病毒疫苗联合免疫实验研究
《中国科学：生命科学》2013年第5期411-420,共10页刘存霞 杜寿文 李昌 王宇航 王茂鹏 李沂 尹荣兰 李霄 任大勇 秦艳青 任静强 金宁一 
国家自然科学基金(批准号:81001342);国家重点基础研究发展计划(批准号:2011CB512110);国家重大传染病防治专项(批准号:2012ZX10001005-006)资助项目
应用自行构建的包含HIV复合表位重组DNA疫苗(pCCMp24)和重组减毒天坛株痘苗病毒(rddVTT-CCMp24),通过小鼠实验开展免疫原性研究.采用肌肉注射方式于第0和21天分别进行初次(prime)和加强(boost)免疫.根据既定的免疫程序,在加强免疫后10天...
关键词：痘苗病毒天坛株 人免疫缺陷病毒 重组DNA PRIME-BOOST 免疫原性 
Potent T cell Responses Induced by Single DNA Vaccine Boosted with Recombinant Vaccinia Vaccine被引量：1
《Virologica Sinica》2013年第2期109-115,共7页Lianxing Liu Chao Qiu Yang Huang Jianqing Xu Yiming Shao 
supported by the China Comprehensive Integrated Programs for Research on AIDS(CIPRA, U19AI51915);by the National Key Projects on Major Infectious Diseases (Grant No. 2008ZX10001-010,2012ZX10001-008);by the National Natural Science Foundation of China (31000413)
Plasmid DNA, an effective vaccine vector, can induce both cellular and humoral immune responses. However, plasmid DNA raises issues concerning potential genomic integration after injection. This issue should be consid...
关键词：HIV VACCINE T cell responses Prime-boost regimen 
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