云南高校图书馆联盟文献共享服务平台- AUTOINHIBITION

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Autoinhibition and cofactors of a helper NLR: 《Science China(Life Sciences)》2025年第3期890-892,共3页Hongyuan Zheng Xuemin Zhou Chenyu Zhao Daowen Wang Zhengqing Fu; supported by the National Science Foundation(IOS-2207677);the key research and development grant from Henan Province(232102111078).; Plants offer a plethora of benefits to human existence.However,in the natural world,plants encounter numerous biotic and abiotic pressures,including the presence of various pathogens that cause serious diseases on cro...; 关键词：IMMUNITY DISEASES CROPS

A SPX domain vacuolar transporter links phosphate sensing to homeostasis in Arabidopsis被引量：1: 《Molecular Plant》2022年第10期1590-1601,共12页Mingda Luan Fugeng Zhao Guangfang Sun Min Xu Aigen Fu Wenzhi Lan Sheng Luan; the China Postdoctoral Science Foundation 2020M683537(to M.L);National Natural Science Foundation of China 32200216(to M.L);the National Science Foundation MCB 2041585(to S.L).; Excess phosphate(Pi)is stored into the vacuole through Pi transporters so that cytoplasmic Pi levels remain stable in plant cells.We hypothesized that the vacuolar Pi transporters may harbor a Pi-sensing mechanism so ...; 关键词：VPT1 Pi signaling AUTOINHIBITION transport activity inositol phosphates

DCLK1 autoinhibition and activation in tumorigenesis被引量：1: 《The Innovation》2022年第1期46-53,共8页Linna Cheng Zejing Yang Wenhao Guo Chengyong Wu Shufang Liang Aiping Tong Zhongwei Cao Rick F.Thorne Sheng-Yong Yang Yamei Yu Qiang Chen; Financial support for this work was provided by the National Natural Science Foundation of China(31741027,82103226,81672722,and 81501368);Natural Science Foundation of Henan Province(212300410243).; Doublecortin-like kinase 1(DCLK1)is upregulated in many tumors and is a marker for tumor stem cells.Accumulating evidence suggests DCLK1 constitutes a promising drug target for cancer therapy.However,the regulation of...; 关键词：inhibited TUMORIGENESIS DCL

Structural dynamics of a plant NLR resistosome:transition from autoinhibition to activation被引量：1: 《Science China(Life Sciences)》2020年第4期617-619,共3页Jing Wang Mawsheng Chern Xuewei Chen; Despite the lack of a cellular,adaptive immune system,plants share with animals an innate immune system and can effectively fight off pathogen attack using two layers of defense response:the first layer consists of pl...; 关键词：NLR IMMUNITY MOUNT

Structure insight of GSDMD reveals the autoinhibition basis in cell pyroptosis: 《Science Foundation in China》2018年第2期25-25,共1页; With the support by the National Natural Science Foundation of China,a research group led by Prof.Li JiXi(李继喜)from Fudan University demonstrates that the C-terminal of gasdermin D(GSDMD-C)acts as an autoinhibition ...; 关键词：科学基础孔结构房间 CASPASES 相互作用复旦大学执行者终端

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin被引量：2: 《Cell Research》2016年第3期336-349,共14页Sheng-Jie Li Jue Wang Lei Ma Chang Lu Jie Wang Jia-Wei Wu Zhi-Xin Wang; The Ca2＋/calmodulin-dependent protein phosphatase calcineurin （CN）, a heterodimer composed of a catalytic subunit A and an essential regulatory subunit B, plays critical functions in various cellular processes such...; 关键词：structure of full-length calcineurin bipartite autoinhibition multi-level activation mechanism of immunosup-pressant stimulation regulation of calcineurin

The conformational states of talin autoinhibition complex and its activation under forces: 《Science China(Life Sciences)》2015年第7期694-703,共10页ZENG Yan ZHANG Yong SONG XianQiang JI QingHua YE Sheng ZHANG RongGuang LOU JiZhong; supported by the National Basic Research Program of China(2014CB910202);National Natural Science Foundation of China(11302240,31070827 and 31222022); Talin is an integrin-binding protein located at focal adhesion site and serves as both an adapter and a force transmitter. Its integrin binding activity is regulated by the intramolecular autoinhibition interaction be...; 关键词：cell adhesion integrin signaling single molecule biophysics molecular dynamics simulations conformational changes

Structural mechanism for autoinhibition of a NOD-like receptor: 《Science Foundation in China》2013年第2期12-12,共1页; With the strong support from the National Natural Science Foundation of China,the research group led by Prof.Chai Jijie reported the crystal structure and autoinhibition mechanism of a member of NODlike receptors(NLRs...; 关键词：晶体结构受体机制国家自然科学基金 NOD 近现代

Differential signaling of Flt3 activating mutations in acute myeloid leukemia:a working model被引量：2: 《Protein & Cell》2011年第2期108-115,共8页Perry M.Chan; Receptor tyrosine kinases couple a wide variety of extracellular cues to cellular responses.The class III subfamily comprises the platelet-derived growth factor receptor,c-Kit,Flt3 and c-Fms,all of which relay cell pr...; 关键词：acute myeloid leukemia receptor tyrosine kinase oncogenic mutation AUTOINHIBITION intracellular traf-ficking

Hypothesis:Intensive insulin therapy-induced mortality is due to excessive serotonin autoinhibition and autonomic dysregulation: 《World Journal of Diabetes》2010年第4期101-108,共8页Undurti N Das; Supported by Department of Biotechnology,India; Action to Control Cardiovascular Risk in Diabetes(ACCORD),The Action in Diabetes and Vascular Disease:Preterax and Diamicron Modified Release Controlled Evaluation and the Veterans Affairs Diabetes Trial were designed...; 关键词：Type 2 diabetes mellitus Cardiovascular events Coronary heart disease Stroke DYSLIPIDEMIA Essential fatty acids NITRIC oxide Free RADICALS Antioxidants Insulin

AUTOINHIBITION