supported by the Major Science and Technology Project of Hainan Province(ZDKJ2021012);National Natural Science Foundation of China(32071805);the National Key Research and Development Program of China(2023YFD2200700)。
Coconut(Cocos nucifera L.)is a key tropical economic tree valued for its fruit flavor,particularly 2-acetyl-1-pyrroline(2AP),a vital aroma metabolite.To enhance high-aromatic coconut breeding efforts,it is essential t...
supported by the Wuhan Branch,Supercomputing Center,Chinese Academy of Sciences,China;supported by the National Aquatic Biological Resource Center(NABRC);supported by the Bureau of Frontier Sciences and Education,Chinese Academy of Sciences(ZDBS-LY-SM026);the National Natural Science Foundation of China(32370457,32122015,32130011,31900316,and 31900339);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0480000);PJA3 grant of ARC Foundation(ARCPJA2021060003830);Equipes 2022 grant of Foundation Recherche Medicale(EQU202203014651).
Meiotic recombination is essential for sexual reproduction and its regulation has been extensively studied in many taxa.However,genome-wide recombination landscape has not been reported in ciliates and it remains unkn...
This corrigendum clarifies information in the article“CRISPR-detector:fast and accurate detection,visualization,and annotation of genomewide mutations induced by genome editing events”by Huang et al.(2023).In the fi...
supported by the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ13-YQ-095 and ZZXT201708);the Start-up Research Fund from BNU-HKBU United International College(UICR0700053-23).
The leading-edge CRISPR/CRISPR-associated technology is revolutionizing biotechnologies through genome editing.To track on/off-target events with emerging new editing techniques,improved bioinformatic tools are indisp...
funded by the National Natural Science Foundation of China(81970904 to MH,81970923 to ZB);Anhui Institute of Translational Medicine(ZHYX2020A005 to LS);the University Synergy Innovation Program of Anhui Province(GXXT-2020-064 to LS);Clinical medicine discipline construction project of Anhui Medical University(2021lcxk008 to LS);the National Key Research and Development Program(2016YFC1000505 to ZB)。
Orofacial clefts(OFCs),particularly cleft lip with or without cleft palate(CL/P)and cleft palate only(CPO),are among the most common birth defects in humans(Mossey et al.,2009;Dixon et al.,2011).The birth prevalence r...
supported by the National Key Research and Development Program of China(2016YFD0100301 to Z.X.M.);the National Natural Science Foundation of China(31670211 and31970237 to Z.X.M.);Sanya Yazhou Bay Science and Technology City(SKJC-2020-02-001 to Z.X.M.);the Central Public-interest Scientific Institution Basal Research Fund(S2021ZD01 to Z.X.M.);the Major Incubation Project of Shenyang Normal University(ZD20210 to P.H.B.);the Hundred Talent Program of Shenyang Normal University(SSDBRJH2002012 to P.H.B.)。
China is the largest rice-producing country,but the genomic landscape of rice diversity has not yet been clarified.In this study,we re-sequence 1070 rice varieties collected from China(400)and other regions in Asia(67...
supported by grants from the National Natural Science Foundation of China(81972927,81773313);Anhui Institute of Translational Medicine(ZHYX2020A005)。
Psoriasis is caused by many factors and is characterized by excessive proliferation of the epidermis and erythema with silver scales on the surface of the skin and concomitant with a variety of diseases(Griffiths et a...
supported by National Institutes of Health R00 MH101367 and R01 MH119243(to P.H.Lee)。
Pathway analysis,also known as gene-set enrichment analysis,is a multilocus analytic strategy that integrates a priori,biological knowledge into the statistical analysis of high-throughput genetics data.Originally dev...
supported by the National Natural Science Foundation of China (Grant No. 31670777);the China National Funds for Distinguished Young Scientists (Grant No. 31722030);the Beijing Advanced Innovation Center for Structural Biology to X.T.;the Tsinghua-Peking Joint Center for Life Sciences (Grant No. 61020100119);the National Thousand Young Talents Program of China (Grant No. 042021011) to X.L.
Noncoding RNAs(ncRNAs) play important roles in many biological processes and provide materials for evolutionary adaptations beyond protein-coding genes, such as in the arms race between the host and pathogen. However,...
supported by the National Key Research and Development Program (2016YFD0100802);the National Science Foundation Collaborative Research grant (DBI-1458515)
Precise mapping of quantitative trait loci(QTLs)is critical for assessing genetic effects and identifying candidate genes for quantitative traits.Interval and composite interval mappings have been the methods of choic...