GENOME-WIDE

作品数：468被引量：1637H指数：17
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Genome-wide methylation profiling identified methylated KCNA3 and OTOP2 as promising diagnostic markers for esophageal squamous cell carcinoma
《Chinese Medical Journal》2024年第14期1724-1735,共12页Yan Bian Ye Gao Chaojing Lu Bo Tian Lei Xin Han Lin Yanhui Zhang Xun Zhang Siwei Zhou Kangkang Wan Jun Zhou Zhaoshen Li Hezhong Chen Luowei Wang 
supported by the Science and Technology Commission of Shanghai Municipality(No.21Y31900100).
Background:Early detection of esophageal squamous cell carcinoma(ESCC)can considerably improve the prognosis of patients.Aberrant cell-free DNA(cfDNA)methylation signatures are a promising tool for detecting ESCC.Howe...
关键词：Esophageal squamous cell carcinoma Cell-free DNA DNA methylation landscape BIOMARKER Liquid biopsy Early detection 
Genome-wide DNA methylation landscape of four Chinese populations and epigenetic variation linked to Tibetan high-altitude adaptation
《Science China(Life Sciences)》2023年第10期2354-2369,共16页Zeshan Lin Yan Lu Guoliang Yu Huajing Teng Bao Wang Yajun Yang Qinglan Li Zhongsheng Sun Shuhua Xu Wen Wang Peng Tian 
the National Key Research and Development Program of China(2016YFC0900402);the Basic Science Center Program(32288101);the National Natural Science Foundation of China(32030020 and 31961130380);the Shanghai Municipal Science and Technology Major Project(2017SHZDZX01)。
DNA methylation(DNAm)is one of the major epigenetic mechanisms in humans and is important in diverse cellular processes.The variation of DNAm in the human population is related to both genetic and environmental factor...
关键词：DNA methylation double-strand bisulfite sequencing Chinese ethnic groups Tibetan high-altitude adaptation 
Pilot study of genome-wide DNA methylation and gene expression for treatment response to escitalopram in panic disorder
《World Journal of Psychiatry》2023年第8期524-532,共9页Zhi-Li Zou Yuan Zhang Yu-Lan Huang Jin-Yu Wang Bo Zhou Hua-Fu Chen 
Supported by The Sichuan Provincial People’s Hospital Translational Medicine Fund,No.2021LY02.
BACKGROUND Antidepressants,particularly selective serotonin reuptake inhibitors,are currently considered the first-line treatment for panic disorder(PD).However,little is known about the relationship between the bioma...
关键词：Panic disorder METHYLATION Expression profiling ESCITALOPRAM 
A revision of the InfiniumPurify R package for genome-wide correction of tumor purity in Infinium DNA methylation array data
《Genes & Diseases》2023年第3期698-700,共3页Phuc H.Hoang 
This work was supported by the Intramural Research Program,Division of Cancer Epidemiology and Genetics,National Cancer Institute,National Institutes of Health,USA.
Understanding DNA methylation(DNAm)alterations in tumors is important to develop novel therapeutic targets and powerful biomarkers,and to gain insights into tumorigenesis processes.As many studies have highlighted the...
关键词：alterations PURITY CORRECTION 
Nitrogen starvation induces genome-wide activation of transposable elements in Arabidopsis
《Journal of Integrative Plant Biology》2022年第12期2374-2384,共11页Yue Wang Yi Liu Shaofeng Qu Wenjie Liang Linhua Sun Dong Ci Zhitong Ren Liu-Min Fan Weiqiang Qian 
the National Natural Science Foundation of China(31970614);the National Key R&D Program of China(2018YFE0204700)。
Nitrogen(N)availability is a major limiting factor for plant growth and agricultural productivity.Although the gene regulation network in response to N starvation has been extensively studied,it remains unknown whethe...
关键词：DNA methylation glutamate synthase nitrogen starvation transcriptional gene silencing transposable element 
Genome-wide DNA methylation profiling reveals candidate biomarkers and probable molecular mechanism of metabolic syndrome被引量：3
《Genes & Diseases》2022年第4期833-836,共4页Su-Jin Baek Hyo-Jeong Ban Sang-Min Park Soo Yeon Kim Siwoo Lee Hee-Jeong Jin 
This study was supported by the“Development of Korean Medicine Original Technology for Preventive Treatment based on Integrative Big Data”grant from the Korea Institute of Oriental Medicine(No.KSN2023120).
Although aberrant DNA methylation changes are significantly associated with the pathogenesis of many diseases,little is known about the molecular mechanisms underlying interactions between DNA methylation and gene exp...
关键词：diseases pathogenesis EPIC 
Epigenome-wide DNA methylation analysis reveals differentially methylation patterns in skeletal muscle between Chinese Chenghua and Qingyu pigs被引量：2
《Journal of Integrative Agriculture》2022年第6期1731-1739,共9页WANG Kai WU Ping-xian WANG Shu-jie JI Xiang CHEN Dong JIANG An-an XIAO Wei-hang JIANG Yan-zhi ZHU Li ZENG Yang-shuang XU Xu QIU Xiao-tian LI Ming-zhou LI Xue-wei TANG Guo-qing 
supported by the grants from the Sichuan Science and Technology Program, China (2020YFN0024);the China Agriculture Research System of MOF and MARA (CARS-35-01A);the National Key R&D Program of China (2018YFD0501204);the National Natural Science Foundation of China (C170102);the Sichuan Innovation Team of Pig, China (sccxtd-2021-08);supported by the High-performance Computing Platform of Sichuan Agricultural University, China
Chenghua(CH)pig and Qingyu(QY)pig are typical Chinese native fatty breeds.CH pig is mainly distributed in Chengdu Plain,while QY pig is widely distributed throughout the mountain areas around the Sichuan Basin.There a...
关键词：DNA methylation reduced representation bisulfite sequencing(RRBS) Chenghua pig Qingyu pig 
Epigenome-wide DNA methylation study of whole blood in patients with sporadic amyotrophic lateral sclerosis被引量：1
《Chinese Medical Journal》2022年第12期1466-1473,共8页Zhengyi Cai Xinmiao Jia Mingsheng Liu Xunzhe Yang Liying Cui 
This work was supported by the National Key Research and Development Program of China(No.2016YFC0905103);the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(CIFMS)(No.2016-I2M-1-004);the Strategic Priority Research Program of the Chinese Academy of Sciences(Nos.XDB39000000,XDB39040100).
Background:Epigenetics,and especially DNA methylation,contributes to the pathogenesis of sporadic amyotrophic lateral sclerosis(SALS).This study aimed to investigate the role of DNA methylation in SALS using whole blo...
关键词：Amyotrophic lateral sclerosis DNA methylation Differentially methylated positions Differentially methylated regions Whole blood 
Genome-wide identification,evolutionary selection,and genetic variation of DNA methylation-related genes in Brassica rapa and Brassica oleracea被引量：1
《Journal of Integrative Agriculture》2022年第6期1620-1632,共13页AN Feng ZHANG Kang ZHANG Ling-kui LI Xing CHEN Shu-min WANG Hua-sen CHENG Feng 
supported by the National Natural Science Foundation of China (NSFC;31872105 and 31801862);the Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences, and the Key Laboratory of Biology and Genetic Improvement of Horticultural Crops, Ministry of Agriculture and Rural Affairs, China
DNA methylation plays an important role in plant growth and development,and in regulating the activity of transposable elements(TEs).Research on DNA methylation-related(DMR)genes has been reported in Arabidopsis,but l...
关键词：DNA methylation Brassica rapa Brassica oleracea evolutionary selection genetic variation gene expression 
Genome-wide methylation profiling of early colorectal cancer using an Illumina Infinium Methylation EPIC BeadChip
《World Journal of Gastrointestinal Oncology》2022年第4期935-946,共12页Yu-Ling Wu Tao Jiang Wei Huang Xing-Yu Wu Peng-Jun Zhang Ya-Ping Tian 
Supported by National Natural Science Foundation of China,No. 81972010;the National Key Research and Development Program of China,No. 2020YFC2002700, and No. 2020YFC2004604
BACKGROUND DNA methylation is a part of epigenetic modification,that is closely related to the growth and development of colorectal cancer(CRC).Specific methylated genes and methylated diagnostic models of tumors have...
关键词：Colorectal cancer DNA methylation 850K Methylation BeadChip Plasma colorectal adenoma 
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