ANTAGONISTS

作品数：143被引量：505H指数：12
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Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration被引量：4
《Journal of Molecular Cell Biology》2021年第1期41-58,共18页Xiangwen Peng Kaa Seng Lai Peilu She Junsu Kang Tingting Wang Guobao Li Yating Zhou jianjian Sun Daqing Jin Xiaolei Xu Lujian Liao Jiandong Liu Ethan Lee Kenneth D.Poss Tao P.Zhong 
This research was supported by grants from the Ministry of Science and Technology of China(2018YFA0801004 and 2018YFA0800103);National Science Foundation of China(NSFC31530044 and NSFC31970780);We acknowledge Guozhen Wu for invaluable assistanee with fish care.We are grateful to Mark Mercola and members of TPZ laboratory for comments on the manuscript and helpful discussions.
Heart regeneration occurs by dedifferentiation and proliferation of pre-existing cardiomyocytes(CMs).However,the signaling mechanisms by which injury induces CM renewal remain incompletely understood.Here,we find that...
关键词：heart regeneration Wnt signaling PAK2 kinase cardiomyocyte proliferation cardiomyocyte dedifferentiation ZEBRAFISH 
WX20120108,a novel IAP antagonist,induces tumor cell autophagy via activating ROS-FOXO pathway被引量：5
《Acta Pharmacologica Sinica》2019年第11期1466-1479,共14页Rui Ding Xin Wang Wei Chen Zhi Li Ai-li Wei Qing-bin Wang Ai-hua Nie Li-li Wang 
the National Natural Science Foundation of China(Grant nos.81803567 and 81773790);the National Science and Technology Major Project of the Ministry of Science and Technology of China(Grant nos.2012ZX09301-001 and 2012ZX09301-003);partially supported by a project of the State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University(FAMP201708K).
Recently,inhibitor of apoptosis proteins(IAPs)and some IAP antagonists were found to regulate autophagy,but the underlying mechanisms remain unclear.WX20120108 is an analogue of GDC-0152(a known IAP antagonist)and dis...
关键词：IAP ANTAGONISTS GDC-0152 WX20120108 apoptosis AUTOPHAGY carcinoma cells Foxo3 ROS CATALASE 
Simple β-lactones are potent irreversible antagonists for strigolactone receptors被引量：5
《Cell Research》2017年第12期1525-1528,共4页Haibo Xian Ruifeng Yao Tianfei Quan Fei Wang Li Chen Xiaoxi DU Wenhao Zhang Haiteng Deng Daoxin Xie Tuoping Luo 
This work was supported by generous start-up funds from the National ＂Young 1000 Talent Plan＂ Program, College of Chemistry and Molecular Engineering, Peking University, Peking-Tsinghua Center for Life Sciences, the National Natural Science Foundation of China （Grant Nos. 31630085, 21472003 and 21672011）, the Ministry of Science and Technology of China （Grant No. 2016YFA0500501）, Tsinghna-Peking Joint Center for Life Sciences （a postdoctoral grant for RY） and China Association for Science and Technology （a grant for RY）.
Dear Editor, Strigolactones （SLs） are a class of plant hormones that play vital roles not only in the control of plant branching and early seedling growth, but also in mediating rhizospheric communication with root...
关键词：Simple β-lactones potent irreversible antagonists for 
Toll-like receptors： potential targets for lupus treatment被引量：8
《Acta Pharmacologica Sinica》2015年第12期1395-1407,共13页Yan-wei WU Wei TANG Jian-ping ZUO 
This work was supported by grants from the National Natu- ral Science Foundation of China （No 81273524, 81273525, and 81322049） and the National Key Basic Research Program （973 Program, 2014CB541906）.
Systemic lupus erythematosus （SLE） is a complex autoimmune disease characterized by the loss of tolerance to self-nuclear antigens. Accumulating evidence shows that Toll-like receptors （TLRs）, previously proven to...
关键词：systemic lupus erythematosus autoimmune diseases Toll-like receptors TLR antagonists immune modulatoryoligonucieotides small molecular inhibitors ANTIBODIES MIRNAS 
The structural and accessory proteins M,ORF 4a,ORF 4b,and ORF 5 of Middle East respiratory syndrome coronavirus(MERS-CoV)are potent interferon antagonists被引量：25
《Protein & Cell》2013年第12期951-961,共11页Yang Yang Ling Zhang Heyuan Geng Yao Deng Baoying Huang Yin Guo Zhengdong Zhao Wenjie Tan 
This work was supported by the National Basic Research Program(973 Program)(No.2011CB504704);the Ministry of Health of China(2014ZX10004-001,2013ZX10004601).
The newly emerged Middle East respiratory syndrome coronavirus(MERS-CoV)is a highly pathogenic respira-tory virus with pathogenic mechanisms that may be driven by innate immune pathways.The goal of this study is to ch...
关键词：MERS-CoV structural proteins accessory proteins interferon antagonists 
Synthesis of 6-sulfamoyl-4-oxoquinoline-3-carboxylic acid derivatives as integrase antagonists with anti-HIV activity被引量：3
《Chinese Chemical Letters》2009年第7期789-792,共4页Zai Gang Luo Cheng Chu Zeng Lei Fu Yang Hong Qiu He Cun Xin Wang Li Ming Hu 
the financial supports of the National Basic Research Program(No.2009CB930200);the Fund from Beijing City Education Committee(No.KM200610005029);Funding Project for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality.
A series of novel 6-sulfamoyl-4-oxoquinoline-3-carboxylic acids derivatives have been synthesized and screened for HIV integrase inhibition activity. Their structures were confirmed by ESI-MS, ^1H NMR and ^13C NMR. 2...
关键词：QUINOLINE INTEGRASE Anti-HIV-1 activity 
Synthesis of benzocycloheptene derivatives as CCR5 antagonists with potent anti-HIV activity被引量：1
《Chinese Chemical Letters》2008年第4期428-430,共3页Yao Liu Jing Su Jun Hai Xiao Shi Bo Jiang Hong Lu Wu Zhong Li Li Wang Xiao Hong Yang Song Li 
supported by the National Basic Research Program of China(No.2004CB518908);the National Natural Science Foundation of China(No.30472093)to SL;the Outstanding Overseas Chinese Scholars Fund of Chinese Academy of Sciences(No.2005-2-6)to SJ.
A series of novel benzocycloheptene derivatives have been synthesized.Their structures were confirmed by MS and ^1H-NMR. These compounds exhibited potent anti-HIV-1 activities.
关键词：HIV-1 entry inhibitors Benzocycloheptene derivatives SYNTHESIS 
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