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Role of homologous recombination/recombineering on human adenovirus genome engineering:Not the only but the most competent solution
《Engineering Microbiology》2024年第1期90-107,共18页Lisa-Marie Dawson Montaha Alshawabkeh Katrin Schröer Fatima Arakrak Anja Ehrhardt Wenli Zhang 
the DFG grant EH 192/5-3(to AE),the internal grant program(project IFF 2024-91);f the Faculty of Health at Witten/Herdecke University(WZ and KS)and the PhD program at Witten/Herdecke University(LK).
Adenoviruses typically cause mild illnesses,but severe diseases may occur primarily in immunodeficient individuals,particularly children.Recently,adenoviruses have garnered significant interest as a versatile tool in ...
关键词：Adenoviral vector Gene therapy Homologous recombination Oncolytic virus Vaccine vector 
Generation of developmentally competent oocytes and fertile mice from parthenogenetic embryonic stem cells被引量：2
《Protein & Cell》2021年第12期947-964,共18页Chenglei Tian Linlin Liu Ming Zeng Xiaoyan Sheng Dai Heng Lingling Wang Xiaoying Ye David L.Keefe Lin Liu 
This work was supported by China National Key R&D Program(2018YFC1003004,2018YFA0107002);the National Natural Science Foundation of China(31430052,91749129);as well as the Stanley H.Kaplan Research Fund at NYU School of Medicine.
Parthenogenetic embryos,created by activation and diploidization of oocytes,arrest at mid-gestation for defective paternal imprints,which impair placental development.Also,viable offspring has not been obtained withou...
关键词：parthenogenetic embryonic stem cells primordial germ cell-like cells IMPRINTING MEIOSIS OOCYTES 
A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts被引量：10
《Cell Research》2019年第9期696-710,共15页Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng 
We thank Prof. Tungtien Sun for the guidance of the written manuscript. This work was supported by National Key Research and Development Program of China (2017YFA0104003,2017YFA0103000,2018YFA0108102);National Natural Science Foundation of China(31730059,31521004,81670590);SLS-Qidong Innovation Fund(2016000663);National Basic Research Program of China(973 Program 2015CB964703).
Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new re...
关键词：hepatic progenitor-like cells (hHPLCs) primary human HEPATOCYTES (PHHs) FIBROBLASTS 
Germline-competent stem cell in avian species and its application
《Asian Journal of Andrology》2015年第3期421-426,共6页Jae Yong Han Hyung Chul Lee Tae Sub Park 
Germ cells are the only cell type in the body that can transfer genetic information to the next generation. Germline-competent stem cells can self-renew and contribute to the germ cell lineage giving rise to pluripote...
关键词：BIRDS germline-competent stem cells primordial germ cells spermatogonial stem cells 
Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice被引量：7
《Cell Research》2014年第9期1050-1066,共17页Jizheng Chen Yang Zhao Chao Zhang Hairong Chen Jin Feng Xiumei Chi Yu Pan Jun Du Min Guo Huang Cao Honghe Chen Zilong Wang Rongjuan Pei Qian Wang Lei Pan Junqi Niu Xinwen Chen Hong Tang 
Acknowledgments We are grateful to Drs T Wakita （National Institute of Infec- tious Diseases, Japan） for pJFH-1 clone, F Chisari （The Scripps Research Institute） for Huh7.5.1 cell line, L Su （University of North Carolina） for cDNA clones of human CD81 and Occludin, and C Rice （The Rockefeller University） for NS5A antibody. We thank Drs Y Tian and S Meng for making a series of transgenic mice; C-X Wei for the genotyping of transgenic mice. We thank Drs L Su, Y-X Fu （The University of Chicago）, R Sun （University of California, Los Angeles） and P Hertzog （Monash University, Australia） for their critical reading and comments on the manuscript. This work was supported by grants from the National Basic Research Program of China （2009CB522506 and 2011CB946104 to HT, 2009CBl18903 to XC, and 2010CB530100 to LP）, the National Natural Science Foundation of China （31200135 to XC and 31030031 to HT）, Knowledge Innovation Program Projects of Chinese Academy of Science （2010-Biols-CAS-0201to HT, and KSCXI-YW-10 to XC and HT）.
The majority of hepatitis C virus （HCV） infection develops chronic infection, which causes steatosis, cirrhosis and hepatocellular carcinoma. However, understanding HCV chronicity and pathogenesis is hampered by its...
关键词：HCV animal model humanized mice immune-competent 
Derivation of Germline Competent Rat Embryonic Stem Cells from DA Rats被引量：3
《Journal of Genetics and Genomics》2012年第11期603-606,共4页Tianda Li Xiao-Yang Zhao Fei Teng Xin Li Minggui Jiang Wei Li Xuepeng Wang Jialiang Wang Lei Liu Zhonghua Liu Liu Wang Qi Zhou 
supported by the grants from the China National Basic Research Program(No.2012CB966501) to X.Z;the National High Technology R&D Program of China (No.2011AA020108) to Q.Z.;the "Strategic Priority Research Program" of the Chinese Academy of Sciences(No. XDA01030101)
The laboratory rat was one of the earliest mammalian species for scientific research and used as animal disease models in physiology, toxicology, behavior, immunology, and tumor-biology for over 150 years （Jacob, 199...
Application of mesenchymal stem cells as a vehicle to deliver replication-competent adenovirus for treating malignant glioma被引量：3
《Chinese Journal of Cancer》2012年第5期233-240,共8页Cui Hai Yong-Min Jin Wen-Biao Jin Zhe-Zhu Han Mei-Nv Cui Xue-Zhe Piao Xiong-Hu Shen Song-Nan Zhang Hong-Hua Sun 
supported by grants from the National Natural Science Foundation of China(No.81160275);the Claison tumor biotherapy research special funds(2011-14)
Although gene therapy was regarded as a promising approach for glioma treatment,its therapeutic efficacy was often disappointing because of the lack of efficient drug delivery systems.Mesenchymal stem cells(MSCs) have...
关键词：脑胶质瘤 病毒复制 间质干细胞 腺病毒 治疗 能力 骨髓间充质干细胞 车辆 
Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis被引量：11
《Cell Research》2011年第11期1634-1637,共4页ManTong  ZhuoLv  LeiLiu  HuiZhu  Qin-YuanZheng  Xiao-YangZhao  WeiLi  Yi-BoWu  Hai-JiangZhang  Hua-JunWu  Zhi-KunLi  FanyiZeng  LiuWang  Xiu-JieWang  Jia-HaoSha QiZhou 
Dear Editor, Ever since the creation of induced pluripotent cells (iPSCs) from adult somatic cells by the ectopic expres- sion of defined transcription factors [1, 2], whether iPS cells are equivalent to embryonic st...
关键词：胚胎干细胞 iPS 四倍体 相似 小鼠 主管 互补 肿瘤 
Transgenic Rice Plants Harboring Genomic DNA from Zizania latifolia Confer Bacterial Blight Resistance被引量：1
《Rice science》2011年第1期17-22,共6页SHEN Wei-wei SONG Cheng-li CHEN Jie FuYaping WU Jian-li JIANG Shao-mei 
supported by the National Natural Science Foundation of China (Grant No. 30760115);Transgenic Program (Grant No. 2008ZX08001-002)
Based on the sequence of a resistance gene analog FZ14 derived from Zizania latifolia （Griseb.）, a pair of specific PCR primers FZ14P1/FZ14P2was designed to isolate candidate disease resistance gene. The pooled-PCR ...
关键词：Zizania latifolia transformation-competent artificial chromosome library resistance-gene analog Oryza sativa bacterial blight resistance gene transfer 
Construction and characterization of the transformation-competent artificial chromosome (TAC) libraries of Leymus multicaulis被引量：1
《Science China(Life Sciences)》2008年第7期604-613,共10页XU YueYu 1,2,3,ZHOU YuLei 4,5 ,SONG LinLin 6 ,ZHANG Yan 3 &ZHAO MaoLin 1 1 Beijing Agro-Biotechnology Research Center,Beijing Academy of Agriculture and Forestry Science,Beijing 100097,China 2 Department of Chemistry and Chemical Engineering,Hunan Institute of Engineering,Xiangtan 411104,China 3 College of Life Science,Capital Normal University,Beijing 100037,China 4 College of Life Science,Zhongkai University of Agriculture and Technology,Guangzhou 510225,China 5 College of Grassland Science,Gansu Agricultural University,Lanzhou 730070,China 6 Department of Biology,Henan Institute of Science and Technology,Xinxiang 453003,China 
the National Natural Science Foundation of China(Grant Nos.30370905 and 30571135);Natural Science Foundation of Beijing City(Grant No.5032009)
Transformation-competent artificial chromosome system is able to clone and transfer genes efficiently in plants.In order to clone genes highly tolerant to barley yellow dwarf virus(BYDV),Aphids,drought and salt from L...
关键词：LEYMUS multicaulis megabase-size DNA transformation-competent artificial chromosome(TAC) genomic library 
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