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SYNAPTIC: 作品数：319被引量：717H指数：13; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：于洋余剑平赵志奇熊志奇杨柳更多>>; 相关机构：中国科学院加拿大多伦多大学第四军医大学滨州医学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家教育部博士点基金更多>>

Microglial EPOR Contribute to Sevofurane‑induced Developmental Fine Motor Defcits Through Synaptic Pruning in Mice: 《Neuroscience Bulletin》2024年第12期1858-1874,共17页Danyi He Xiaotong Shi Lirong Liang Youyi Zhao Sanxing Ma Shuhui Cao Bing Liu Zhenzhen Gao Xiao Zhang Ze Fan Fang Kuang Hui Zhang; supported by grants from the National Natural Science Foundation of China(82101534,82171170,and 82201414);the Natural Science Foundation of Shaanxi Provence(2024JCYBMS659);the Science and Technology Plan in Xi’an of China(23YXYJ0134)。; Clinical researches including the Mayo Anesthesia Safety in Kids (MASK) study have found that children undergoing multiple anesthesia may have a higher risk of fne motor control difculties. However, the underlying mec...; 关键词：Erythropoietin Microglia Synaptic pruning Sevofurane Fine motor defcits

Loss of TET Activity in the Postnatal Mouse Brain Perturbs Synaptic Gene Expression and Impairs Cognitive Function: 《Neuroscience Bulletin》2024年第11期1699-1712,共14页Ji-Wei Liu Ze-Qiang Zhang Zhi-Chuan Zhu Kui Li Qiwu Xu Jing Zhang Xue-Wen Cheng Han Li Ying Sun Ji-Jun Wang Lu-Lu Hu Zhi-Qi Xiong Yongchuan Zhu; supported by the Shanghai Sailing Program(20YF1442200);the Natural Science Foundation of Shanghai(21ZR1455200);the STI2030-Major Project(2022ZD0214200);the National Natural Science Foundation of China(32371075),and the Shanghai Pujiang Program(22PJ1412300).; Conversion of 5-methylcytosine(5mC)to 5-hydroxymethylcytosine(5hmC)by ten-eleven translocation(TET)family proteins leads to the accumulation of 5hmC in the central nervous system;however,the role of 5hmC in the postna...; 关键词：5hmC.TET DNA demethylation SYNAPSE Learning and memory EPIGENETICS

Developmental Impairments of Synaptic Refinement in the Thalamus of a Mouse Model of Fragile X Syndrome: 《Neuroscience Bulletin》2024年第4期439-450,共12页Xiaotong Wu Yali Liu Xiaomeng Wang Lu Zheng Libiao Pan Hao Wang; supported by grants from the National Natural Science Foundation of China(32171014,31970940,31671100,31622027);the Zhejiang Provincial Natural Science Foundation of China(LR18H090001);the Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2018PT31041);the Program for Introducing Talents in Discipline to Universities,the Fundamental Research Funds for Central Universities(2021FZZX001-37).; While somatosensory over-reactivity is a common feature of autism spectrum disorders such as fragile X syndrome(FXS),the thalamic mechanisms underlying this remain unclear.Here,we found that the developmental eliminat...; 关键词：Fragile X syndrome Synaptic refinement VPm Sensory over-reactivity

Biphasic Cholinergic Modulation of Reverberatory Activity in Neuronal: 《Neuroscience Bulletin》2023年第5期731-744,共14页Xiao-Wei Li Yi Ren Dong-Qing Shi Lei Qi Fang Xu Yanyang Xiao Pak-Ming Lau Guo-Qiang Bi; supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32030200);the National Natural Science Foundation of China(31070935 and 62173326);the National Basic Research Program of China(2013CB835100);the Youth Innovation Promotion Association,CAS(2022367)。; Acetylcholine(ACh)is an important neuromod-ulator in various cognitive functions.However,it is unclear how ACh influences neural circuit dynamics by altering cellular properties.Here,we investigated how ACh influ-ence...; 关键词：ACETYLCHOLINE Neuronal network REVERBERATION Synaptic current EXCITABILITY

Direction Selectivityof TmY Neurites in Drosophila: 《Neuroscience Bulletin》2023年第5期759-773,共15页Yinyin Zhao Shanshan Ke Guo Cheng Xiaohua Lv Jin Chang Wei Zhou; supported by grants from the National Natural Science Foundation of China(61890950 and 31871027);Fundamental Research Funds for the Central Universities/HUST(2016YXMS034 and 2014TS015);the Director Fund of WNLO,and the China Postdoctoral Science Foundation(2015T80788).; The perception of motion is an important func-tion of vision.Neural wiring diagrams for extracting direc-tional information have been obtained by connectome recon-struction.Direction selectivity in Drosophila is thoug...; 关键词：Direction selectivity TmY-ds-Synaptic connection Two-photon calcium imaging DROSOPHILA

Bi-directional Control of Synaptic Input Summation and Spike Generation by GABAergic Inputs at the Axon Initial Segment: 《Neuroscience Bulletin》2023年第1期1-13,共13页Ziwei Shang Junhao Huang Nan Liu Xiaohui Zhang; supported by the National Natural Science Foundation of China(32130043 and 32071025);the Interdisciplinary Research Fund of Beijing Normal University,China.; Differing from other subtypes of inhibitory interneuron,chandelier or axo-axonic cells form depolarizing GABAergic synapses exclusively onto the axon initial segment(AIS)of targeted pyramidal cells(PCs).However,the de...; 关键词：GABAergic inputs Axon initial segment Synaptic integration Axo-axonic cell Chandelier cell NEURON simulation Dynamic clamp

Viral Tools for Neural Circuit Tracing被引量：11: 《Neuroscience Bulletin》2022年第12期1508-1518,共11页Qing Liu Yang Wu Huadong Wang Fan Jia Fuqiang Xu; This review was supported by the National Science and Technology Innovation 2030(2021ZD0201003);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32030200);the National Natural Science Foundation of China(31830035);the Shenzhen Key Laboratory of Viral Vectors for Biomedicine(ZDSYS20200811142401005).; Neural circuits provide an anatomical basis for functional networks.Therefore,dissecting the structure of neural circuits is essential to understanding how the brain works.Recombinant neurotropic viruses are important...; 关键词：Neural circuit Viral tool ANTEROGRADE RETROGRADE Trans-synaptic

Loss of C9orf72 in Microglia Drives Neuronal Injury by Enhancing Synaptic Pruning in Aged and Alzheimer’s Disease Mice: 《Neuroscience Bulletin》2022年第3期327-330,共4页Mengmeng Wang Yuanyuan Jiang Zhihui Huang; the National Natural Science Foundation of China(92049104 and 82103210);the Research Start-up Project by Hangzhou Normal University(4125C5021920453 and 4125C50220204106).; Many diseases are caused by the expansion of simple sequence repeats scattered throughout the human genome;they are defined as repeat expansion diseases.The size of the repeat unit ranges from trinucleotides(the vast ...; 关键词：C9orf72 ALZHEIMER diseases

CCL2/CCR2 Contributes to the Altered Excitatory-inhibitory Synaptic Balance in the Nucleus Accumbens Shell Following Peripheral Nerve Injury-induced Neuropathic Pain被引量：2: 《Neuroscience Bulletin》2021年第7期921-933,共13页Xiao-Bo Wu Qian Zhu Yong-Jing Gao; Grants from the National Natural Science Foundation of China(32030048,31871064,and 31671091).; The medium spiny neurons(MSNs)in the nucleus accumbens(NAc)integrate excitatory and inhibitory synaptic inputs and gate motivational and emotional behavior output.Here we report that the relative intensity of excitato...; 关键词：E/I balance Synaptic transmission LTD CCL2 CCR2 Nucleus accumbens Neuropathic pain

Synaptic Adaptation Contributes to Stimulus-Specific Adaptation in the Thalamic Reticular Nucleus被引量：2: 《Neuroscience Bulletin》2020年第12期1538-1541,共4页Yu-Ying Zhai Ryszard Auksztulewicz Pei-Run Song Zhi-Hai Sun Yu-Mei Gong Xin-Yu Du Jie He Xiongjie Yu; the National Natural Science Foundation of China(31671081 and 31872768)。; Dear Editor,Stimulus-specific adaptation(SSA)is the process whereby a neuron responds more strongly to rare stimuli than to the same stimuli presented in a repetitive way.This phenomenon has been regarded as one of th...; 关键词：auditory CORTEX COCHLEAR

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